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    SELF-REGULATING PRESSURE SOURCE
    61.
    发明申请
    SELF-REGULATING PRESSURE SOURCE 审中-公开
    自调压源

    公开(公告)号：WO2012148900A1

    公开(公告)日：2012-11-01

    申请号：PCT/US2012/034772

    申请日：2012-04-24

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PRESIDENT & FELLOWS OF HARVARD COLLEGE ,  RUS, Daniela ,  CHEN, Xin ,  ONAL, Cagdas, Denizel ,  WHITESIDES, George, M.

    Inventor： RUS, Daniela ,  CHEN, Xin ,  ONAL, Cagdas, Denizel ,  WHITESIDES, George, M.

    IPC: G05D16/06 ,  G05D16/10 ,  F15B15/10

    CPC classification number: G05D16/0636 ,  F15B21/06

    Abstract: Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.

    Abstract translation: 自调压源。 压力源包括封闭化学单元推进剂的室。 可移动的凸台连接到密封空气室的可变形膜，可移动的凸台和空气室设置在室内。 催化剂设置在膜周围，以便被凸起覆盖在缩回位置，使得单组分推进剂被催化剂分解以产生气体。 在室内气体压力将增加，导致空气室中的空气压缩，从而将凸台拉到缩回位置以覆盖催化剂，从而调节室内的压力。 自调节压力源特别适用于流体弹性致动器。

    PAPER-BASED MICROFLUIDIC SYSTEMS
    64.
    发明申请
    PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
    基于纸张的微流体系统

    公开(公告)号：WO2009121041A3

    公开(公告)日：2009-12-17

    申请号：PCT/US2009038699

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    CPC classification number: B01L3/502707 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/025 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    Abstract translation: 本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。 测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。 微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

    MICROFLUIDIC DETECTOR
    66.
    发明申请
    MICROFLUIDIC DETECTOR 审中-公开

    公开(公告)号：WO2008060449A3

    公开(公告)日：2008-05-22

    申请号：PCT/US2007/023595

    申请日：2007-11-09

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BUTTE, Manish, J. ,  WONG, Amy, P. ,  SHARPE, Arlene, H. ,  WHITESIDES, George, M.

    Inventor： BUTTE, Manish, J. ,  WONG, Amy, P. ,  SHARPE, Arlene, H. ,  WHITESIDES, George, M.

    IPC: G01N33/543 ,  G01N33/569

    Abstract: Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.

    FABRICATION OF ISOLATED NANOSTRUCTURES AND/OR ARRAYS OF NANOSTRUCTURES
    68.
    发明申请
    FABRICATION OF ISOLATED NANOSTRUCTURES AND/OR ARRAYS OF NANOSTRUCTURES 审中-公开
    分离的纳米结构和/或纳米结构阵列的制造

    公开(公告)号：WO2008018923A2

    公开(公告)日：2008-02-14

    申请号：PCT/US2007/007101

    申请日：2007-03-22

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  XU, Qiaobing ,  BAO, Jiming ,  CAPASSO, Federico ,  WHITESIDES, George, M.

    Inventor： XU, Qiaobing ,  BAO, Jiming ,  CAPASSO, Federico ,  WHITESIDES, George, M.

    CPC classification number: B81C1/00031 ,  B08B17/065 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/658 ,  G02B2207/101

    Abstract: Methods for fabricating nanostructures and articles associated therewith are described. In some embodiments, an isolated nanostructure (e.g., a metal nanowire) or an array of nanostructures can be fabricated by depositing a material (e.g., a metal) on a surface having a plurality of protrusions or indentations. At least a portion of the deposited material may be embedded in an encapsulating material, and the encapsulating material can be cut, for instance, to form a thin slice that includes the deposited material at least partially embedded therein. In some instances, the slice can be positioned on a surface in a desired arrangement. The encapsulating material can be removed from the surface to form one or more isolated nanostructures of the deposited material. Advantageously, dimensions of the nanostructures can be controlled to, e.g., 15 run, to form nanostructures having a variety of shapes and geometries (e.g., wires, rings, and cylinders). Nanostructures can also be formed in a variety of materials, including metals, ceramics, and polymers. In addition, nanostructures can also be fabricated over large areas (e.g., greater than 1 mm 2 ). In some cases, these nanostructures are positioned in association with other components, e.g., to form a functional component of a device.

    Abstract translation: 描述了用于制造纳米结构和与其相关的制品的方法。 在一些实施例中，分离的纳米结构（例如金属纳米线）或纳米结构阵列可以通过在具有多个突起或凹陷的表面上沉积材料（例如金属）来制造。 至少一部分沉积材料可以嵌入封装材料中，并且可以切割封装材料，例如以形成包括至少部分嵌入其中的沉积材料的薄片。 在一些情况下，切片可以以期望的布置定位在表面上。 包封材料可从表面去除以形成沉积材料的一个或多个分离的纳米结构。 有利地，可以将纳米结构的尺寸控制为例如15nm，以形成具有各种形状和几何形状（例如线材，环和圆柱体）的纳米结构。 纳米结构也可以用各种材料形成，包括金属，陶瓷和聚合物。 另外，纳米结构也可以在大面积上制造（例如，大于1mm 2）。 在一些情况下，这些纳米结构与其他组分相关联地定位，例如以形成装置的功能组分。

    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS
    70.
    发明申请
    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
    微流控网络中导电通路，微环境和微结构的制作

    公开(公告)号：WO2007061448A2

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/019787

    申请日：2006-05-18

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BRUZEWICZ, Derek, A. ,  BONCHEVA-BETTEX, Mila ,  WHITESIDES, George, M. ,  SIEGEL, Adam ,  WEIBEL, Douglas, B. ,  SHEVKOPLYAS, Sergey ,  MARTINEZ, Andres

    Inventor： BRUZEWICZ, Derek, A. ,  BONCHEVA-BETTEX, Mila ,  WHITESIDES, George, M. ,  SIEGEL, Adam ,  WEIBEL, Douglas, B. ,  SHEVKOPLYAS, Sergey ,  MARTINEZ, Andres

    IPC: H05K3/10

    CPC classification number: H05K3/101 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0415 ,  B33Y80/00 ,  H05K1/0272 ,  H05K1/032 ,  H05K3/389 ,  H05K2201/0162 ,  H05K2201/0305 ,  H05K2203/128 ,  Y10T29/49117

    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.

    Abstract translation: 这里公开了各种微流体装置和固体，典型地导电装置，其可以使用诸如模具的装置形成。 在某些实施例中，形成的器件包括通过凝固存在于一个或多个微流体通道中的液态金属（以下称为“微型固态”器件）形成的导电通路。 在某些这样的装置中，其中可以在微流体结构中的区域之间形成和/或重新形成电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电子部件。 在某些实施方案中，在微流体通道中形成的固体金属丝/导电通路可保持包含在微流体结构内。 在某些这样的实施例中，所形成的导电通路可位于承载流动流体的结构的其他微流体通道附近，使得导电通路可产生与其相互作用的能量（例如电磁能和/或热能），并且 /或影响流动的流体和/或包含在其中或由其承载的组件。 在其他实施例中，可以将微观结构从微流体模具移除以形成独立结构。 在某些实施方案中，所形成的固体金属结构可与入射在结构上的光能相互作用或可用于制造轻质电极。 本发明的另一方面涉及可以包括这些导电通路/连接的自组装结构的形成。

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