-
Patent Agency Ranking
公开(公告)号：KR1020150045089A
公开(公告)日：2015-04-28
申请号：KR1020130124322
申请日：2013-10-18
Applicant: (주)바이오액츠
Abstract: 본발명은아포토시스(apoptosis)가진행되고있는사멸세포(apoptotic cell)에특이적으로결합하는단일구조(1가)의펩타이드를글리신및 라이신을이용하여다수개의가지로이루어진다가구조의펩타이드로개질시켜사멸세포와의결합능을향상시킨사멸세포표적용펩타이드및 이의용도에관한것으로, 본발명에따른펩타이드는종양, 심근경색, 뇌졸중및 동맥경화등의조직의사멸세포를보다적은처리량및 짧은반응시간으로도표적할 수있으며, 상기펩타이드에영상물질과결합시킴으로써상기질환들의상태진단및 영상화에유용하게적용될수 있다. 또한, 본발명에따른펩타이드에상기질환들에효과적인치료물질을결합시켜제공함으로서상기질환조직에약물을선택적으로전달할수 있어약물전달용조성물, 상기질환예방또는치료용약학조성물로유용하게적용할수 있다.
Abstract translation: 本发明涉及靶向凋亡细胞的肽及其用途。 本发明使用甘氨酸和赖氨酸将分别具有能够与这种凋亡细胞建立特异性结合的单一结构（1）的肽重整成包括多个分支的多结构肽，从而增强肽与凋亡细胞的结合能力 。 根据本发明，肽可以以小剂量和短的反应时间靶向涉及肿瘤，心肌梗死，中风和动脉粥样硬化的组织的凋亡细胞。 肽还可以与成像剂偶联用于疾病的诊断和成像。 此外，本发明可以将有效的疾病治疗物质与肽偶联以选择性地将药物递送至疾病组织，并作为预防或治疗疾病的药物递送剂组合物或药物组合物使用。
-
公开(公告)号：KR101478505B1
公开(公告)日：2015-01-06
申请号：KR1020110079332
申请日：2011-08-10
Applicant: (주)바이오액츠
IPC: G01N33/58 , G01N33/52 , C07D403/06 , C07D493/10
Abstract: 본 발명은 비닐설폰기를 가지는 염료 화합물의 생체 분자 표지 방법에 관한 것으로, 비닐설폰기를 가지는 염료 화합물의 용해 시 반드시 물을 사용하는 것을 특징으로 한다.
-
公开(公告)号：KR1020110122784A
公开(公告)日：2011-11-11
申请号：KR1020100042209
申请日：2010-05-05
Applicant: (주)바이오액츠
IPC: C07D403/06 , C07D403/12 , C12Q1/68 , A61K31/404 , A01N57/24
CPC classification number: C07D403/06 , A01N57/24 , A61K31/404 , C07D403/12 , C12Q1/6816
Abstract: PURPOSE: A novel cyanine compound for labeling bio molecules and a method for preparing the same are provided to prevent by-product generation after binding of the dye and the bio molecules. CONSTITUTION: A cyanine compound is dented by chemical formula 1. The compound is labeled in a biomolecule, nanoparticles, or organic compounds. The biomolecule is protein, peptide, carbohydrate, sugar, fat, antibody, proteoglycan, glycoprotein, or siRNA. A method for preparing the compound comprises: a step of reacting a compound of chemical formula 4 with a compound of chemical formula 5 or 7 to prepare a compound of chemical formula 6a; a step of reacting the compound of chemical formula 6a with a compound of chemical formula 8 to prepare a compound of chemical formula 9; a step of reacting the compound of chemical formula 9 with a compound of chemical formula 6b to prepare a compound of chemical formula 10; a step of reacting the compound of chemical formula 10 with 1,1'-carbonyldiimodazole or N,N-disuccinimidyl carbonate to prepare a compound of chemical formula 11a or 11b; and a step of reacting the compound of chemical formula 11a or 11b with a compound of chemical formula 12 under the presence of a Hunig base.
Abstract translation: 目的：提供一种用于标记生物分子的新颖花青化合物及其制备方法，以防止染料和生物分子结合后产生副产物。 构成：花青化合物通过化学式1凹陷。化合物在生物分子，纳米颗粒或有机化合物中标记。 生物分子是蛋白质，肽，碳水化合物，糖，脂肪，抗体，蛋白多糖，糖蛋白或siRNA。 制备化合物的方法包括：使化学式4的化合物与化学式5或7的化合物反应以制备化学式6a化合物的步骤; 使化学式6a的化合物与化学式8的化合物反应以制备化学式9的化合物的步骤; 使化学式9的化合物与化学式6b的化合物反应以制备化学式10的化合物的步骤; 使化学式10的化合物与1,1'-羰基二咪唑或N，N-二琥珀酰亚胺基碳酸酯反应以制备化学式11a或11b的化合物的步骤; 以及在Hunig碱的存在下使化学式11a或11b的化合物与化学式12的化合物反应的步骤。
-
公开(公告)号：KR1020110052156A
公开(公告)日：2011-05-18
申请号：KR1020090109088
申请日：2009-11-12
Applicant: (주)바이오액츠
CPC classification number: C09B45/06
Abstract: PURPOSE: A black acid dye composition is provided to make the color of desired concentration using small amount of dye. CONSTITUTION: A black acid dye composition comprises compound of 30~70wt.%, including hydrophilic sulfone amide group, and a water-insoluble compound of 30~70wt.% A high dye absorption rate is obtained by improving the affinity of black acidity dye composition to fiber. A high build up property is maintained for high concentration dyeing.
Abstract translation: 目的：提供黑色酸性染料组合物以使用少量的染料使所需浓度的颜色变得良好。 构成：黑色酸性染料组合物含有30〜70重量％的化合物，包括亲水性砜酰胺基和30〜70重量％的不溶于水的化合物。通过提高黑色酸性染料组合物的亲和力，可获得高染料吸收率 到纤维。 维持高浓度染色性能。
-
公开(公告)号：KR100795972B1
公开(公告)日：2008-01-21
申请号：KR1020060066567
申请日：2006-07-14
Applicant: (주)바이오액츠
IPC: C07C311/00 , C09B29/039
Abstract: 본 발명은 2개의 방향족 고리가 설폰아미드기로 연결되어 있는 구조를 가지며, 우수한 견뢰도 특성과 항균성을 나타내는, 하기 화학식 1로 표시되는 항균 활성을 갖는 산성 염료 및 이를 함유하는 항균 염료 조성물에 관한 것이다.
[화학식 1]
-
-
-
-
Search Results
65
records
(took 0.025 seconds)
