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公开(公告)号：KR101125058B1
公开(公告)日：2012-03-21
申请号：KR1020090090954
申请日：2009-09-25
Applicant: (주)바이오액츠
IPC: C07D311/80 , C07D493/04 , G01N33/48 , G01N33/68
Abstract: 본 발명은 다음 화학식 1c로 표시되는 물질 표지용 화합물, 그 제조 중간체 및 그 제조방법에 관한 것이다.
[화학식 1c]
상기 식에서 치환기는 명세서에 정의한 바와 같다.Abstract translation: 本发明涉及一种用于由式1c中，一家制造中间体及其制造的方法表示标记物质的化合物。
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公开(公告)号：KR1020110033763A
公开(公告)日：2011-03-31
申请号：KR1020100042210
申请日：2010-05-05
Applicant: (주)바이오액츠
IPC: C07D403/02 , C07D209/08 , C09B23/08
CPC classification number: C09B23/083 , C09B23/06 , C09B23/086 , G01N33/533 , C07D403/02 , C07D209/08
Abstract: PURPOSE: A novel benzindocyanine compound and a method for preparing the same are provided to ensure high stability and easy storage. CONSTITUTION: A method for preparing a novel benaindocyanine compound of chemical formula 1 comprises: a step of reacting a compound of chemical formula 4 with a compound of chemical formula 5 or 7 to obtain a compound of chemical formula 6a; a step of reacting the compound of chemical formula 6a with a compound of chemical formula 8 to obtain a compound of chemical formula 9; a step of reacting the compound of chemical formula 9 with a compound of chemical formula 6b to obtain a compound of chemical formula 10; a step of reacting the compound of chemical formula 10 with 1,1'-carbonyldiimidazoel or N,N-disuccinimidylcarbonate to obtain a compound of chemical formula 11a or 11b; and a step of reaction the compound of chemical formula 11a or 11b with a compound of chemical formula 12 under the presence of Hunig base.
Abstract translation: 目的：提供新的苯并吲哚菁化合物及其制备方法，以确保高稳定性和易于储存。 构成：制备化学式1的新型贝恩染色化合物的方法包括：使化学式4的化合物与化学式5或7的化合物反应的步骤，得到化学式6a的化合物; 使化学式6a的化合物与化学式8的化合物反应，得到化学式9的化合物的工序; 使化学式9的化合物与化学式6b的化合物反应，得到化学式10的化合物的工序; 使化学式10化合物与1,1'-羰基二咪唑啉或N，N-二琥珀酰亚胺基碳酸酯反应，得到化学式11a或11b化合物的步骤; 以及在Hunig碱存在下使化学式11a或11b的化合物与化学式12的化合物反应的步骤。
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公开(公告)号：KR101695617B1
公开(公告)日：2017-01-16
申请号：KR1020100042210
申请日：2010-05-05
Applicant: (주)바이오액츠
IPC: C07D403/02 , C07D209/08 , C09B23/08
CPC classification number: C09B23/083 , C09B23/06 , C09B23/086 , G01N33/533
Abstract: 본발명은생체분자표지를위한다음화학식 1로표시되는신규벤즈인도시아닌화합물및 그제조방법에관한것이다. [화학식 1]식중에서, R, R, R, R, B, m 및 n은각각명세서에정의한바와같다.
Abstract translation: 本公开涉及用于标记生物分子的新型苯并吲哚菁化合物及其制备方法。
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公开(公告)号：KR101149535B1
公开(公告)日：2012-05-25
申请号：KR1020100030228
申请日：2010-04-02
IPC: C07D403/02 , C07D209/04
CPC classification number: C07D403/06 , C07D209/08
Abstract: 본 발명은 생체 분자 표지를 위한 다음 화학식 1로 표시되는 신규 시아닌 화합물 및 그 제조 방법에 관한 것이다.
[화학식 1]
식 중에서, R
1 , R
2 , R
3 , R
4 , B, m 및 n은 각각 명세서에 정의한 바와 같다.-
公开(公告)号：KR100896308B1
公开(公告)日：2009-05-07
申请号：KR1020070079236
申请日：2007-08-07
Applicant: (주)바이오액츠
IPC: C09B29/039 , C07C311/00
Abstract: 본 발명은 2개의 방향족 고리가 설폰아미드기로 연결되어 있는 구조를 가지며, 우수한 견뢰도 특성과 항균성을 나타내는, 하기 화학식 1로 표시되는 항균 활성을 갖는 산성 염료 및 이를 함유하는 항균 염료 조성물에 관한 것이다.
[화학식 1]-
Patent Agency Ranking
公开(公告)号：KR100872097B1
公开(公告)日：2008-12-05
申请号：KR1020070067281
申请日：2007-07-04
Applicant: (주)바이오액츠
CPC classification number: C09B45/26 , C09B67/0041
Abstract: An asymmetric azo-based metal complex dye compound, and a dye composition containing the compound are provided to reduce the generation of remaining waste water after dyeing and to improve water fastness, washing fastness and light fastness. An asymmetric azo-based metal complex dye compound is represented by the chemical formula 1, wherein R1 to R9 are independently -H, -NH2, -SO3H, -OH, -COOH, -CH3, -F, -Cl, -Br, -OCH3, -NH-(C6H5), -NH-(C6H4)CH3, -NHSO2-(C6H5), -NHSO2-(C6H4)Cl, -NHSO2-(C6H4)COOH, -NHCOCH3, -NH2CH3, -SO2NH2, -NHSO2CH3, -N(CH3)2, -N(C2H5)2, -NO2, -NHCONH2, -CONH2, -N(C2H4OH)2 or -OC2H5.
Abstract translation: 提供不对称偶氮系金属络合物染料化合物和含有该化合物的染料组合物，以减少染色后剩余废水的产生，提高耐水性，耐洗色牢度和耐光性。 不对称偶氮类金属络合物染料化合物由化学式1表示，其中R 1至R 9独立地为-H，-NH 2，-SO 3 H，-OH，-COOH，-CH 3，-F，-Cl，-Br， -OCH 3，-NH-（C 6 H 5），-NH-（C 6 H 4）CH 3，-NHSO 2 - （C 6 H 5），-NHSO 2 - （C 6 H 4）Cl，-NHSO 2 - （C 6 H 4）COOH，-NHCOCH 3，-NH 2 CH 3，-SO 2 NH 2， -NHSO 2 CH 3，-N（CH 3）2，-N（C 2 H 5）2，-NO 2，-NHCONH 2，-CONH 2，-N（C 2 H 4 OH）2或-OC 2 H 5。
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公开(公告)号：KR1020080007035A
公开(公告)日：2008-01-17
申请号：KR1020060066567
申请日：2006-07-14
Applicant: (주)바이오액츠
IPC: C07C311/00 , C09B29/039
Abstract: An acidic dye compound having antimicrobial activity is provided to have a structure in which two aromatic rings are linked by a sulfonamide group, and exhibit good fastness characteristics and excellent antimicrobial properties. An acidic dye compound having antimicrobial activity has a structure represented by the following formula of B^1-Ar^1-SO2NH-Ar^2-B^2. An acidic dye composition having antimicrobial activity comprises at least one of the acidic dye compounds, and further at least one dye compound selected from the group consisting of C.I. Acid Red 337, C.I. Acid Blue 324, C.I. Acid Yellow 199, and C.I. Acid Orange 67. The composition exhibits antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, or both strains thereof.
Abstract translation: 提供具有抗微生物活性的酸性染料化合物以具有其中两个芳环通过磺酰胺基团连接的结构，并表现出良好的牢度特性和优异的抗菌性能。 具有抗微生物活性的酸性染料化合物具有由下式表示的结构：B 1 -Ar 1-SO 2 NH -Ar 2-B 2。 具有抗微生物活性的酸性染料组合物包含至少一种酸性染料化合物，以及至少一种选自C.I. 酸性红337，C.I。 酸性蓝324，C.I。 酸性黄199和C.I. 酸性橙67.组合物对金黄色葡萄球菌，肺炎克雷伯杆菌或其两种菌株表现出抗菌活性。
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公开(公告)号：KR100688310B1
公开(公告)日：2007-03-02
申请号：KR1020050080366
申请日：2005-08-30
Abstract: Provided is an azo-based metal complex reactive dye, which has advantages of both azo-based metal complex dyes and reactive dyes, and shows an improved sunlight fastness and a high fixation ratio. The azo-based metal complex reactive dye is represented by a formula of MxAyBz, wherein M represents a metal selected from the group consisting of Cr, Co, Fe, Cu and Ni; each of x and y represents 1 or 2, and z is 1, 2 or 3; A is selected from tridendate ligands represented by formulae 7-13; B represents H2O or is selected from tridendate ligands represented by the formulae 7-13; each of R1 and R2 is selected from the group consisting of -OH, -NH2, -COOH, -NHCOCH2COCH3 and -NH-(C6H5); and at least one of R3-R9 is -NHCOCHBrCH2Br or -NHCOCBr=CH2, and each of the remaining substituents of R3-R9 is selected from the group consisting of -H, -NH2, -SO3H, -OH, -COOH, -CH3, -OCH3, -NH-(C6H5), -NH-(C6H5)CH3, -NHSO2-(C6H5), -NHSO2-(C6H5)Cl, -NHSO2-(C6H5)COOH, -NHCOCH3, -NH2CH3, -SO2NH2, -NHSO2CH3, -N(CH3)2, -N(C2H5)2, -NO2, -NHCONH2, -CONH2, -N(C2H4OH)2 and -OC2H5.
Abstract translation: 本发明提供一种偶氮类金属络合物活性染料，其兼具偶氮类金属络合物染料和活性染料两者的优点，并且显示出改善的日光牢度和高固色率。 偶氮类金属络合物反应性染料由式M x A y B z表示，其中M表示选自Cr，Co，Fe，Cu和Ni的金属; x和y中的每一个代表1或2，并且z是1,2或3; A选自由式7-13表示的十三酸配体; B代表H 2 O或选自式7-13代表的十三配位体; R 1和R 2各自选自-OH，-NH 2，-COOH，-NHCOCH 2 COCH 3和-NH-（C 6 H 5）; 并且R3-R9中的至少一个是-NHCOCHBrCH2Br或-NHCOCBr = CH2，并且R3-R9的其余取代基中的每一个选自-H，-NH2，-SO3H，-OH，-COOH， - （C 6 H 5）CH 3，-NHSO 2 - （C 6 H 5）， - NHSO 2 - （C 6 H 5）Cl，-NHSO 2 - （C 6 H 5）COOH，-NHCOCH 3，-NH 2 CH 3， - -N（CH 2）5，-NO 2，-NHCONH 2，-CONH 2，-N（C 2 H 4 OH）2和-OC 2 H 5。
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公开(公告)号：KR101556391B1
公开(公告)日：2015-10-01
申请号：KR1020130124322
申请日：2013-10-18
Applicant: (주)바이오액츠
Abstract: 본발명은아포토시스(apoptosis)가진행되고있는사멸세포(apoptotic cell)에특이적으로결합하는단일구조(1가)의펩타이드를글리신및 라이신을이용하여다수개의가지로이루어진다가구조의펩타이드로개질시켜사멸세포와의결합능을향상시킨사멸세포표적용펩타이드및 이의용도에관한것으로, 본발명에따른펩타이드는종양, 심근경색, 뇌졸중및 동맥경화등의조직의사멸세포를보다적은처리량및 짧은반응시간으로도표적할 수있으며, 상기펩타이드에영상물질과결합시킴으로써상기질환들의상태진단및 영상화에유용하게적용될수 있다. 또한, 본발명에따른펩타이드에상기질환들에효과적인치료물질을결합시켜제공함으로서상기질환조직에약물을선택적으로전달할수 있어약물전달용조성물, 상기질환예방또는치료용약학조성물로유용하게적용할수 있다.
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公开(公告)号：KR1020150045089A
公开(公告)日：2015-04-28
申请号：KR1020130124322
申请日：2013-10-18
Applicant: (주)바이오액츠
Abstract: 본발명은아포토시스(apoptosis)가진행되고있는사멸세포(apoptotic cell)에특이적으로결합하는단일구조(1가)의펩타이드를글리신및 라이신을이용하여다수개의가지로이루어진다가구조의펩타이드로개질시켜사멸세포와의결합능을향상시킨사멸세포표적용펩타이드및 이의용도에관한것으로, 본발명에따른펩타이드는종양, 심근경색, 뇌졸중및 동맥경화등의조직의사멸세포를보다적은처리량및 짧은반응시간으로도표적할 수있으며, 상기펩타이드에영상물질과결합시킴으로써상기질환들의상태진단및 영상화에유용하게적용될수 있다. 또한, 본발명에따른펩타이드에상기질환들에효과적인치료물질을결합시켜제공함으로서상기질환조직에약물을선택적으로전달할수 있어약물전달용조성물, 상기질환예방또는치료용약학조성물로유용하게적용할수 있다.
Abstract translation: 本发明涉及靶向凋亡细胞的肽及其用途。 本发明使用甘氨酸和赖氨酸将分别具有能够与这种凋亡细胞建立特异性结合的单一结构（1）的肽重整成包括多个分支的多结构肽，从而增强肽与凋亡细胞的结合能力 。 根据本发明，肽可以以小剂量和短的反应时间靶向涉及肿瘤，心肌梗死，中风和动脉粥样硬化的组织的凋亡细胞。 肽还可以与成像剂偶联用于疾病的诊断和成像。 此外，本发明可以将有效的疾病治疗物质与肽偶联以选择性地将药物递送至疾病组织，并作为预防或治疗疾病的药物递送剂组合物或药物组合物使用。
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