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公开(公告)号：KR100291140B1
公开(公告)日：2001-05-15
申请号：KR1020000062334
申请日：2000-10-23
Applicant: 한국과학기술연구원
IPC: A61K31/366
Abstract: 본 발명은 탄닌(tannin), 또는 탄닌 유래 갈산(gallic acid) 또는 엘라그산(ellagic acid)을 포함하는 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료용 조성물에 관한 것으로, 탄닌, 갈산 또는 엘라그산은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, 동물의 혈청 GOT(glutamate-oxaloacetate transaminase), GPT(glutamate-pyruvate transaminase), γGTP(γ-glutamyl transpeptidase) 및 혈중 지질의 농도를 낮추고, 간세포의 손상 및 지방간화를 강력히 억제하므로, 본 발명의 조성물은 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료제로서 유용하게 사용될 수 있다.
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公开(公告)号：KR1020010015490A
公开(公告)日：2001-02-26
申请号：KR1020000056166
申请日：2000-09-25
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A food or drink composition including a bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid is provided. This composition prevents hypertension, arteriosclerosis and a stroke of paralysis by increasing the plasma high density lipoprotein level in the body. CONSTITUTION: The composition for increasing plasma high density lipoprotein(HDL) level comprises a bioflavonoid of formula(I), wherein i) R1 to R9 are each independently hydrogen; hydroxy group; C1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C2-10 or C16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; rutinosyl group; or rhaminosyl group, and ii) X is a single or double bond. The bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid can be added to various foods or drinks.
Abstract translation: 目的：提供包含式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果提取物的食品或饮料组合物。 该组合物通过增加体内血浆高密度脂蛋白水平来预防高血压，动脉硬化和瘫痪中风。 构成：用于增加血浆高密度脂蛋白（HDL）水平的组合物包含式（I）的生物类黄酮，其中i）R 1至R 9各自独立地为氢; 羟基; 任选地被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自羟基，烷氧基，芳氧基，卤素取代基的取代基取代的取代基取代的C1-9烷氧基 ，硝基和酰氨基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C5-9环烷氧基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C 5-9环烷基羰基氧基; 任选被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自下组取代的取代基的苯基取代的C 2-10或C16-18酰氧基：羟基， 烷氧基，芳氧基，卤素和硝基; 芸香酰基; 或rhaminosyl基，和ii）X是单键或双键。 式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果的提取物可以添加到各种食品或饮料中。
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65.发明授权
公开(公告)号：KR100258584B1
公开(公告)日：2000-07-01
申请号：KR1019970055580
申请日：1997-10-28
Applicant: 한국과학기술연구원
IPC: A61K36/752 , A61P9/00
Abstract: PURPOSE: A composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) is provided, which is useful for preventing and treating various cardiovascular diseases by decreasing blood low density lipoprotein(LDL) cholesterol. CONSTITUTION: A process fro the preparation of composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) comprises the steps of: washing the peel of tangerine originated in Korea, and drying at normal temperature to get Aurantii Nobilis Pericarpium; adding 95% ethanol, keeping at normal temperature for 24hours, and filtering to get extract and solid residue; extracting the solid residue twice more by the same process, and gathering extracts altogether; and concentrating the extract using a rotary vacuum evaporator under decompression to get concentrated extract containing bio-flavonoids.
Abstract translation: 目的：提供含有抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的橙皮提取物的组合物，其可用于通过降低血液低密度脂蛋白（LDL）胆固醇来预防和治疗各种心血管疾病。 构成：含有橙皮提取物抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的组合物的制备方法包括以下步骤：洗涤起始于韩国的橘皮，并在常温下干燥以得到Aurantii Nobilis Pericarpium; 加入95％乙醇，在常温保持24小时，过滤得到提取物和固体残渣; 通过相同的方法提取固体残渣两次，并收集提取物; 并在减压下使用旋转式真空蒸发器浓缩提取物，得到含有生物黄酮的浓缩提取物。
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Patent Agency Ranking
公开(公告)号：KR1020000019719A
公开(公告)日：2000-04-15
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L33/10 , A23C9/152 , A23V2002/00 , A23V2200/3262 , A61K31/7048
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising diosmin are provided, for treating and preventing hyper lipidemia and arteriosclerosis. CONSTITUTION: The pharmaceutical composition comprises diosmin in effective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt%, preferably 0.1-5 wt% of diosmin. Diosmin inhibits HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester, and reduces the concentration of cholesterol in blood and neutral lipids. Also diosmin strongly inhibits the macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface.
Abstract translation: 目的：提供药物组合物和包含diosmin的功能性食品，用于治疗和预防高脂血症和动脉硬化。 构成：药物组合物含有有效量的diosmin; 和药学上可接受的载体。 功能性食品包含diosmin的0.01-10重量％，优选0.1-5重量％。 Diosmin抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及将胆固醇转化为胆固醇酯的胆固醇和ACAT（酰基辅酶A;胆固醇-O-酰基转移酶）的生物合成，并降低胆固醇的浓度 在血液和中性脂质中。 此外，diosmin还强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面。
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公开(公告)号：KR1020000019717A
公开(公告)日：2000-04-15
申请号：KR1019980037959
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L2/52 , A21D2/14 , A23C9/13 , A23C9/152 , A23L7/109 , A23L13/428 , A23L23/00 , A23L27/63 , A61K31/70 , Y10S514/824 , A61K2300/00
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising bioflavonoids are provided, for treating and preventing hyper lipidemia, arteriosclerosis and a liver disease. CONSTITUTION: The pharmaceutical composition comprises rutin, quercetin or their mixture ineffective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt% of rutin, quercetin or their mixture. Rutin can be obtained from a fruit, a leaf, a trunk and a flower of buck wheat and be used in the form of a powder or an extract. Rutin and quercetin being bioflavonoids inhibit HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester in the body. Therefore rutin and quercetin reduce the concentration of cholesterol in blood, inhibit strongly a macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface, and protect a liver.
Abstract translation: 目的：提供包含生物类黄酮的药物组合物和功能性食品，用于治疗和预防高脂血症，动脉硬化和肝脏疾病。 构成：药物组合物含有芦丁，槲皮素或其混合物无效量; 和药学上可接受的载体。 功能性食品包含0.01-10重量％的芦丁，槲皮素或其混合物。 芦丁可以从水果，叶子，树干和小麦花中获得，并以粉末或提取物的形式使用。 芦丁和槲皮素是生物类黄酮抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及胆固醇和ACAT（酰基CoA;胆固醇-O-酰基转移酶）的生物合成，其将胆固醇转化为身体中的胆固醇酯 。 因此，芦丁和槲皮素降低血液中胆固醇的浓度，强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面，并保护肝脏。
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公开(公告)号：KR1020000000752A
公开(公告)日：2000-01-15
申请号：KR1019980020561
申请日：1998-06-03
Applicant: 한국과학기술연구원
IPC: A61K31/35 , A61K31/715
CPC classification number: A23L33/10 , A23L2/38 , A23V2002/00 , A23V2200/30 , A61K31/352 , A61K31/704
Abstract: PURPOSE: A composition is provided to help to improve the blood flow by preventing a platelet cohesion and a formation of a thrombus at the same time. CONSTITUTION: The naringin or the naringenin is effective to prevent and treat the sclerosis of the arteries by the platelet cohesion, and to improve the blood flow by preventing the platelet cohesion generated by collagen. The medical composition is a preventing agent of the platelet cohesion and comprises by mixing the naringin or the naringenin as an efficient component and a carrier permitted for a pharmacology. And a diluent, a disintegrator, a sweetening agent, a lubricant, and a cordial are included.
Abstract translation: 目的：提供一种组合物，以帮助通过同时预防血小板凝聚和形成血栓来改善血流量。 构成：柚皮苷或柚皮苷有效预防和治疗血小板聚集的动脉硬化，并通过防止胶原蛋白产生的血小板凝聚力来改善血流量。 该药物组合物是血小板聚集性的预防剂，包括将柚皮苷或柚皮苷作为有效成分和允许药理学的载体混合。 并且包括稀释剂，崩解剂，甜味剂，润滑剂和亲和物。
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公开(公告)号：KR1019990083000A
公开(公告)日：1999-11-25
申请号：KR1019990011996
申请日：1999-04-07
Applicant: 한국과학기술연구원
IPC: A23L1/221
CPC classification number: A61K36/725 , A23L27/105 , A61K36/75 , A61K36/752 , A61K36/8962 , A61K36/899 , A61K36/9068 , A61K2300/00
Abstract: 본발명은마늘 1 내지 30 중량%, 양파 10 내지 50 중량%, 생강 0.2 내지 10 중량%, 대추 5 내지 40 중량% 및감귤류과피분말또는이의추출물 10 내지 50 중량%를포함하는심장순환기질환예방및 건강증진에유용한양념조성물에관한것으로, 이를음식에첨가함으로써간질환, 암, 심장순환기질환등의성인병예방및 건강증진효과를얻을수 있다.
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