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    LIQUID FORMULATIONS AND PROCESS FOR EXTENDING THE VASE LIFE OF CUT FLOWERS
    61.
    发明申请
    LIQUID FORMULATIONS AND PROCESS FOR EXTENDING THE VASE LIFE OF CUT FLOWERS 审中-公开
    用于延长切花的花瓶寿命的液体配方和方法

    公开(公告)号：WO1995034199A1

    公开(公告)日：1995-12-21

    申请号：PCT/US1995007517

    申请日：1995-06-13

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  SHAFER, Warren, E. ,  WOOLARD, Dereck, D. ,  SAMUEL, Neyyan, K., P. ,  VENBURG, Gregory, D. ,  DEVISETTY, Bala, N. ,  HEIMAN, Daniel, F.

    IPC: A01N03/02

    CPC classification number: A01N3/02

    Abstract: Liquid formulations, suitable for use in extending the vase-life of cut flowers and which resist the development of unsightly discoloration and turbidity comprise from about 55 parts by weight to about 98 parts by weight of a sugar; from about 0.05 part by weight to about 1 part by weight of an inhibitor of aminocyclopropanecarboxylate synthase selected from L-trans-2-amino-4-(2-aminoethoxy)-3-butenoic acid and carboxymethoxylamine; from about 0.1 part by weight to about 5 parts by weight of an antimicrobial agent; from about 1 part by weight to about 5 parts by weight of aluminum sulfate; and from about 0.1 part by weight to about 5 parts by weight of a dicarboxylic acid of from two to six carbon atoms. All parts by weight based upon the total weight of the dissolved solid components.

    Abstract translation: 适用于延长切花的花瓶寿命并且抵抗难看的变色和浊度的发展的液体制剂包含约55重量份至约98重量份的糖; 约0.05重量份至约1重量份的选自L-反式-2-氨基-4-（2-氨基乙氧基）-3-丁烯酸和羧基甲氧基胺的氨基环丙烷羧酸酯合酶抑制剂; 约0.1重量份至约5重量份的抗微生物剂; 约1重量份至约5重量份的硫酸铝; 和约0.1重量份至约5重量份的二至六个碳原子的二羧酸。 基于溶解的固体组分的总重量的所有重量份。

    DETECTION OF DIFFERENT HIV GENOTYPES UTILIZING A SYNTHETIC PEPTIDE-MODIFIED IMMUNOASSAY
    62.
    发明申请
    DETECTION OF DIFFERENT HIV GENOTYPES UTILIZING A SYNTHETIC PEPTIDE-MODIFIED IMMUNOASSAY 审中-公开
    使用合成肽修饰的免疫球蛋白检测不同的HIV基因组

    公开(公告)号：WO1995033206A1

    公开(公告)日：1995-12-07

    申请号：PCT/US1995004421

    申请日：1995-04-10

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  GALLARDA, James, L. ,  STONE, Barbara, L. ,  LIU, Douglas, J. ,  HARRINGTON, Susan, K. ,  DAWSON, George, J. ,  WU, Ping

    IPC: G01N33/569

    CPC classification number: C07K14/005 ,  C07K2319/00 ,  C12N2740/16122 ,  G01N33/56988

    Abstract: An assay to simultaneously detect the presence of one or more HIV subtypes of HIV-1 antibody and/or HIV-2 antibody in a test sample is disclosed. The analytes are captured on either the same or different solid phases, and the presence of the analytes is determined by detecting a signal generated by using a cocktail of synthetic and recombinant antigen-containing indicator reagents. Preferred indicator reagents include a synthetic19 amino acid cyclic peptide homologous to an immunodominant region of HIV-1 gp 41 and a synthetic19 amino acid cyclic peptide homologous to an immunodominant region of HIV-2 gp 36.

    Abstract translation: 公开了一种在测试样品中同时检测HIV-1抗体和/或HIV-2抗体的一种或多种HIV亚型的存在的测定法。 分析物被捕获在相同或不同的固相上，并且通过检测通过使用含有合成和重组抗原的指示剂试剂的混合物产生的信号来确定分析物的存在。 优选的指示剂包括与HIV-1 gp 41的免疫显性区域同源的合成的19个氨基酸的环肽和与HIV-2 gp 36的免疫显性区域同源的合成的19个氨基酸的环肽。

    AEROSOL DRUG FORMULATIONS CONTAINING VITAMIN E
    64.
    发明申请
    AEROSOL DRUG FORMULATIONS CONTAINING VITAMIN E 审中-公开
    含有维生素E的AEROSOL DRUG配方

    公开(公告)号：WO1995024892A1

    公开(公告)日：1995-09-21

    申请号：PCT/US1995002764

    申请日：1995-03-02

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  FU LU, Mou-Ying ,  GUPTA, Pramod, K. ,  ADJEI, Akwete, L.

    IPC: A61K09/12

    CPC classification number: A61K9/008 ,  A61K31/355

    Abstract: Pharmaceutical compositions for aerosol delivery comprising (a) a medicament, (b) a non-chlorofluorocarbon propellant, and (c) tocopherol or a pharmaceutically acceptable derivative thereof, as well as a method for preparing such compositions in which unwanted aggregation of the medicament is prevented without the use of surfactants or cosolvents.

    Abstract translation: 用于气溶胶递送的药物组合物包括（a）药物，（b）非氯氟烃推进剂和（c）生育酚或其药学上可接受的衍生物，以及制备这样的组合物的方法，其中药物的不想要的聚集是 防止不使用表面活性剂或助溶剂。

    PROCESS FOR LABELLING ACRIDINIUM TO MICROPARTICLES AND APPLICATION IN AN INSTRUMENT
    65.
    发明申请
    PROCESS FOR LABELLING ACRIDINIUM TO MICROPARTICLES AND APPLICATION IN AN INSTRUMENT 审中-公开
    将微量元素标记在仪器中的应用程序

    公开(公告)号：WO1995022059A1

    公开(公告)日：1995-08-17

    申请号：PCT/US1995001527

    申请日：1995-02-06

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  SHAH, Dinesh, O. ,  CHANDRA, Tarun ,  KLOSTERMAN, Kurt

    IPC: G01N33/58

    CPC classification number: G01N33/585

    Abstract: Embodiments of the invention provide methods of preparing an activated acridinium microparticle. Generally, the methods involve direct covalent coupling or an affinity format. The direct covalent coupling method involves coating a microparticle with a proteinaceous compound. Then, a 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate is coupled to the proteinaceous compound. In the affinity format, a microparticle is coated with a biotinylated proteinaceous compound. The microparticle is reacted with an anti-biotin labelled 10-methyl-N-tosyl-N-(2-carboxyethyl)-9-acridinium carboximide trifluoromethane sulfonate. Methods are also provided for using such a microparticle. Those methods of use can estimate transfer efficiency, calibrate optics, and measure membrane pore size of a chemiluminescence based instrument. Test elements for analytical instruments are also provided.

    Abstract translation: 本发明的实施方案提供了制备活化的吖啶微粒的方法。 通常，该方法涉及直接共价偶联或亲和格式。 直接共价偶联法包括用蛋白质化合物包被微粒。 然后，将10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸酯与蛋白质化合物偶联。 在亲和性形式中，微粒被生物素化的蛋白质化合物包被。 将微粒与抗生物素标记的10-甲基-N-甲苯磺酰基-N-（2-羧乙基）-9-吖啶鎓三氟甲磺酸盐反应。 还提供了使用这种微粒的方法。 这些使用方法可以估计传递效率，校准光学和测量基于化学发光的仪器的膜孔径。 还提供了分析仪器的测试元件。

    APPARATUS AND METHOD FOR THERMAL CYCLING NUCLEIC ACID ASSAYS
    66.
    发明申请
    APPARATUS AND METHOD FOR THERMAL CYCLING NUCLEIC ACID ASSAYS 审中-公开
    用于循环核酸测定的装置和方法

    公开(公告)号：WO1995018676A1

    公开(公告)日：1995-07-13

    申请号：PCT/US1995000413

    申请日：1995-01-11

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ZUREK, Thomas, F. ,  HANLEY, Kathleen, A. ,  PEPE, Curtis, J.

    IPC: B01L07/00

    CPC classification number: B01L7/52 ,  G05D23/138 ,  Y10T436/115831 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/25

    Abstract: The method and apparatus for thermal cycling of nucleic acid assys includes a blended fluid stream produced from a plurality of constant velocity, constant volume, constant temperature fluid streams wherein to provide a variable temperature, constant velocity, constant volume fluid stream which is introduced into a sample chamber for heating and cooling samples contained therein. By diverting and altering the ratio of the constant temperature fluid streams relative to one another, the blended fluid stream is rapidly variable in temperature, providing for almost instantaneous temperature change within the environment defined by the sample chamber.

    Abstract translation: 核酸组件的热循环的方法和装置包括由多个等速恒定体积的恒温流体流产生的混合流体流，其中提供可变温度恒定速度的恒定体积流体流，其被引入到 样品室，用于加热和冷却其中所含的样品。 通过转移和改变恒温流体流相对于彼此的比例，混合的流体流在温度上快速变化，从而在由样品室限定的环境内提供几乎瞬间的温度变化。

    MACROCYCLIC IMMUNOMODULATORS WITH NOVEL CYCLOHEXYL RING REPLACEMENTS
    68.
    发明申请
    MACROCYCLIC IMMUNOMODULATORS WITH NOVEL CYCLOHEXYL RING REPLACEMENTS 审中-公开
    具有新环孢菌素环替代物的大分子免疫调节剂

    公开(公告)号：WO1995015328A1

    公开(公告)日：1995-06-08

    申请号：PCT/US1994013210

    申请日：1994-11-14

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  LULY, Jay, R.

    IPC: C07D498/18

    CPC classification number: C07D498/18 ,  C07H19/01

    Abstract: Novel macrolide compounds (semisynthetic analogs of asomycin and FK-506) of formula (II) and phamaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a substituent selected from among radicals having the subformulae (IIa), (IIe), (IIj) and (IIk) and other heretocyclic radicals, as well as pharmaceutical compositions and methods of immunomodulatory treatment utilizing same.

    Abstract translation: 式（II）的新型大环内酯类化合物（asomycin和FK-506的半合成类似物）及其药学上可接受的盐，酯，酰胺和前药，其中X是选自具有子式（IIa），（IIe）， （IIj）和（IIk）和其它含环基团，以及利用其免疫调节治疗的药物组合物和方法。

    SINGLE-USE CLOSURE, PARTICULARLY FOR ANAESTHETIC-AGENT CONTAINER
    69.
    发明申请
    SINGLE-USE CLOSURE, PARTICULARLY FOR ANAESTHETIC-AGENT CONTAINER 审中-公开
    一次性封闭，特别适用于麻醉剂容器

    公开(公告)号：WO1995013972A1

    公开(公告)日：1995-05-26

    申请号：PCT/US1994012537

    申请日：1994-11-01

    Applicant: ABBOTT LABORATORIES ,  DE RUBEIS, Fabio ,  GENGA, Rodolfo

    Inventor： ABBOTT LABORATORIES

    IPC: B65D55/08

    CPC classification number: B65D55/0845 ,  A61M16/183 ,  B65D47/10

    Abstract: The closure has a locking ring (107) connected to a collar (108), having an internal planar face (109), at a frangible annular portion (110), which can be ruptured to gain immediate access to the contents of a container. A stopper member (120) is fixed to the collar (108) for selectively connecting the closure (100) to an anaesthetic transfer device. A discharge passage (123) and a venting passage (124) extend through the stopper member (120) for communication with a container (103) engaged by the collar (108). A first pierceable diaphragm (125) is located within and occludes the discharge passage (123), and second pierceable diaphragm (129) is located within and occludes the venting passage (124). Upon rupturing the frangible annular portion (110), the internal face (109) prevents the closure (100) from being fitted on another container.

    Abstract translation: 闭合件具有连接到轴环（108）的锁定环（107），其具有在易碎的环形部分（110）处的内部平面（109），其可被破裂以便立即进入容器的内容物。 止动构件（120）固定到套环（108）上，用于选择性地将闭合件（100）连接到麻醉转移装置。 排出通道（123）和排气通道（124）延伸穿过止动件（120），用于与由套环（108）接合的容器（103）连通。 第一可穿透隔膜（125）位于排出通道（123）内并阻塞排出通道（123），第二可穿透隔膜（129）位于通气通道（124）内并阻塞通气通道（124）。 在破裂易碎环形部分（110）时，内表面（109）防止封闭件（100）装配在另一个容器上。

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