公开(公告)号：WO1996040854A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009689

申请日：1996-06-07

Applicant: ALCON LABORATORIES, INC. ,  CHOWHAN, Masood, A. ,  QUINTANA, Ronald, P. ,  ASGHARIAN, Bahram ,  HONG, Bor-Shyue ,  BILBAULT, Thierry ,  ROSENTHAL, Ruth, Ann

Inventor： ALCON LABORATORIES, INC.

IPC: C11D03/386

CPC classification number: C11D3/046 ,  A61L12/082 ,  A61L12/145 ,  C11D3/0078 ,  C11D3/042 ,  C11D3/2044 ,  C11D3/2065 ,  C11D3/38618 ,  C11D3/38663 ,  C11D3/48

Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Abstract translation: 公开了含有眼科可接受的酶的稳定液体酶组合物和涉及将这些组合物与聚合物抗微生物剂组合使用的方法，用于同时对隐形眼镜进行清洁和消毒。 还公开了日常使用方案。

公开(公告)号：WO1996040303A1

公开(公告)日：1996-12-19

申请号：PCT/US1996006743

申请日：1996-05-10

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  FREEMAN, Charles ,  JINKERSON, David, L. ,  KARAKELLE, Mutlu ,  LeBOEUF, Albert, R.

IPC: A61L27/00

CPC classification number: A61F2/16 ,  A61F2/14 ,  A61L27/16 ,  A61L2430/16 ,  C08F220/18 ,  C08F220/30 ,  G02B1/043 ,  C08L33/04 ,  C08L33/06 ,  C08L33/14

Abstract: Disclosed are improved soft, high refractive index, acrylic materials having an elongation of at least 150 %. These materials, especially useful as intraocular lens materials, contain two principal monomers: an aryl acrylic hydrophobic monomer and a hydrophilic monomer.

Abstract translation: 公开了具有至少150％的伸长率的改进的柔软，高折射率的丙烯酸类材料。 这些特别用作眼内透镜材料的材料含有两种主要单体：芳基丙烯酸疏水单体和亲水性单体。

公开(公告)号：WO1996039147A2

公开(公告)日：1996-12-12

申请号：PCT/US1996006289

申请日：1996-05-03

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YANNI, John, Michael ,  ROBERTSON, Stella, M. ,  HAYAKAWA, Eiji ,  NAKAKURA, Masashi

IPC: A61K31/645

CPC classification number: A61K31/00

Abstract: Topical ophthalmic formulations of the invention contain as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof. The formulations are useful for treating allergic eye diseases such as allergic conjunctivitis, vernal conjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis.

Abstract translation: 本发明的局部眼用制剂含有作为活性成分的11-（3-二甲基氨基亚丙基）-6,11-二氢二苯并[b，e]氧杂七环素-2-乙酸或其药学上可接受的盐。 该制剂可用于治疗过敏性眼部疾病如过敏性结膜炎，春季结膜炎，春季角膜结膜炎和巨型乳头状结膜炎。

公开(公告)号：WO1996037191A1

公开(公告)日：1996-11-28

申请号：PCT/US1995006587

申请日：1995-05-24

Applicant: ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  JANI, Rajni

Inventor： ALCON LABORATORIES, INC.

IPC: A61K09/10

CPC classification number: A61K31/795 ,  A61K47/585 ,  A61K2300/00

Abstract: Aqueous pharmaceutical compositions containing a synergistic combination of ciprofloxacin and a polystyrene sulfonic acid polymer are described, wherein the compositions are clear solutions which are comfortable and have sustained release. Methods for use of the compositions are also disclosed.

Abstract translation: 描述了含有环丙沙星和聚苯乙烯磺酸聚合物的协同组合的水性药物组合物，其中组合物是舒适且具有持续释放的澄清溶液。 还公开了使用组合物的方法。

公开(公告)号：WO1996013235A2

公开(公告)日：1996-05-09

申请号：PCT/US1995012240

申请日：1995-09-26

Applicant: ALCON LABORATORIES, INC. ,  MARASON, Eric

Inventor： ALCON LABORATORIES, INC. ,  WILKINSON, David ,  ROWE, T., Scott

IPC: A61F09/00

CPC classification number: G02B6/4298 ,  A61B3/0008 ,  A61F9/007 ,  F21W2131/205 ,  G02B6/0006

Abstract: A fiberoptic illumination system having an attenuator with a "multiple wedge" aperture that more uniformly attenuate the light beam striking the fiberoptic without changing the color temperature of the light beam or affecting the exit divergence angle of the light beam, an optical housing design having orthogonal lights paths that allows two fiberoptics to be illuminated from the same bulb, two bulbs located in primary and back-up positions, respectively, mounted on a rotating carousel and a retinal protection filter that filters out wavelengths of light harmful to the retina.

Abstract translation: 光纤照明系统具有具有“多楔形”孔径的衰减器，其更均匀地衰减射入光纤的光束而不改变光束的色温或影响光束的出射发散角;具有正交的光学壳体设计 光路径允许两个光纤从相同的灯泡照亮，分别位于主和备用位置的两个灯泡，分别安装在旋转的转盘和视网膜保护滤波器上，该过滤器滤除对视网膜有害的光的波长。

公开(公告)号：WO1996010407A1

公开(公告)日：1996-04-11

申请号：PCT/US1995012171

申请日：1995-09-25

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  HELLBERG, Mark, R. ,  DEAN, Thomas, R. ,  ZINKE, Paul, W. ,  SELLIAH, Robert, D. ,  BISHOP, John, E.

IPC: A61K31/557

CPC classification number: A61K31/5575 ,  C07C405/00 ,  C07C405/0016

Abstract: Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

Abstract translation: 公开了可用于治疗青光眼和高眼压症的9-脱氧前列腺素。 这些9-脱氧前列腺素中的一些是新颖的。 还公开了包含这种前列腺素的眼科药物组合物。

公开(公告)号：WO1996006603A1

公开(公告)日：1996-03-07

申请号：PCT/US1995009724

申请日：1995-08-02

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  PARK, Joonsup ,  FALCETTA, Joseph, J.

IPC: A61K31/135

CPC classification number: C11D3/48 ,  C07C217/08 ,  C07C233/18 ,  C07F7/081 ,  C11D1/62 ,  C11D3/0078

Abstract: Ophthalmic compositions of quaternary ammonium compounds containiing a polyalkylkene oxide moiety useful as antimicrobial agents are disclosed. Methods for using the compositions are also disclosed. In addition, polymers with no molecular weight distribution are disclosed.

Abstract translation: 公开了含有可用作抗微生物剂的聚烷氧基氧化物部分的季铵化合物的眼科组合物。 还公开了使用组合物的方法。 另外，公开了没有分子量分布的聚合物。

公开(公告)号：WO1996000055A1

公开(公告)日：1996-01-04

申请号：PCT/US1995007723

申请日：1995-06-19

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  GAN, Owen ,  JANI, Rajni ,  LORENZETTI, Ole, J.

IPC: A61K09/00

CPC classification number: A61K9/0048 ,  Y10S514/912

Abstract: Improved ophthalmic irrigating solutions are described. The solutions include one or more drugs for controlling intraocular pressure, an antioxidant/free radical scavenger, electrolytes, a cellular energy source, bicarbonate, and a buffer. Methods of using the solutions in connection with ophthalmic surgical procedures are also described.

Abstract translation: 描述了改进的眼科冲洗溶液。 该溶液包括一种或多种用于控制眼内压的药物，抗氧化剂/自由基清除剂，电解质，细胞能量源，碳酸氢盐和缓冲液。 还描述了使用与眼科手术相关的方案的方法。

公开(公告)号：WO1995017492A1

公开(公告)日：1995-06-29

申请号：PCT/US1994014593

申请日：1994-12-19

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DESAI, Nayan, N. ,  QUINTANA, Ronald, P. ,  CHOWHAN, Masood

IPC: C11D01/82

CPC classification number: C11D3/3738 ,  C11D1/82 ,  C11D3/0078 ,  Y10S516/01 ,  Y10S516/02 ,  Y10S516/07

Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.

Abstract translation: 提供组合物和方法用于清洁和润湿隐形眼镜，特别是刚性的透气隐形眼镜。 组合物包含低分子量聚环氧烷改性的硅氧烷，其特别有效地从隐形眼镜的表面去除脂质。

公开(公告)号：WO1995009004A1

公开(公告)日：1995-04-06

申请号：PCT/US1994011091

申请日：1994-09-29

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YORK, Billie, M. ,  NIXON, Jon, C. ,  SAMS, Karen, C.

IPC: A61K38/18

CPC classification number: A61K38/1808 ,  A61K31/404 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K39/00 ,  C07K14/415 ,  C07K2319/00 ,  Y10S514/912 ,  Y10S514/913 ,  A61K2300/00

Abstract: The intraocular use of combinations of lens epithelial cell growth stimulators (e.g., TGF- beta ) and antimetabolites (e.g., mitomycin C) is described. The combination is applied to the capsular bag to prevent or retard the formation of secondary cataracts following cataract surgery. The lens epithelial cell stimulators activate DNA synthesis in dormant lens epithelial cells, and thereby make those cells susceptible to the antimetabolites. This enables the antimetabolites to suppress the proliferation of lens epithelial cells to a much greater extent, relative to the proliferation observed when the metabolites alone are utilized. The increased suppression of the growth of lens epithelial cells results in a significant improvement in the ability to prevent or retard the formation of opacities on the lens capsule (i.e., secondary cataracts).

Abstract translation: 描述了晶状体上皮细胞生长刺激剂（例如TGF-β）和抗代谢物（例如丝裂霉素C）的组合的眼内使用。 该组合应用于囊袋以防止或延缓白内障手术后继发性白内障的形成。 晶状体上皮细胞刺激剂激活休眠晶状体上皮细胞中的DNA合成，从而使这些细胞对抗代谢物敏感。 相对于单独使用代谢物时观察到的增殖，这使得抗代谢物能够在更大程度上抑制晶状体上皮细胞的增殖。 晶状体上皮细胞生长增加的抑制导致防止或延缓晶状体胶囊（即二次性白内障）不透明形成的能力的显着改善。