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    CROSS-LINKED POLYETHYLENE OXIDE COATINGS TO IMPROVE THE BIOCOMPATIBILITY OF IMPLANTABLE MEDICAL DEVICES
    2.
    发明申请
    CROSS-LINKED POLYETHYLENE OXIDE COATINGS TO IMPROVE THE BIOCOMPATIBILITY OF IMPLANTABLE MEDICAL DEVICES 审中-公开
    交联聚乙烯氧化物涂料，以提高可植入医疗器械的生物活性

    公开(公告)号：WO1996014887A1

    公开(公告)日：1996-05-23

    申请号：PCT/US1995014912

    申请日：1995-11-16

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  Llanos, Gerard ,  KARAKELLE, Mutlu ,  HARRIS, Joe, Milton

    IPC: A61L27/00

    CPC classification number: A61F2/16 ,  A61L2/206 ,  A61L27/34 ,  A61L29/085 ,  A61L33/068 ,  C08L71/02

    Abstract: Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized, end-capped PEO which is attached at one end to the medical device. The PEO compounds are then cross-linked by 1) exposure to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network or 2) by reacting the free functionalized ends of a sufficient number of bound PEO compounds with a crosslinking agent whose functional groups are reactive toward the bound PEO chain's functionalized ends. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.

    Abstract translation: 公开了提供用于可植入医疗装置的改善的生物相容性的聚环氧乙烷（PEO）涂层。 PEO涂层包括功能化的端封PEO，其一端连接到医疗装置。 然后将PEO化合物通过1）暴露于高能量源足以使PEO化合物形成交联的不溶性网络的时间进行交联，或2）通过使足够数量的结合的游离官能化末端反应 具有交联剂的PEO化合物，其官能团对结合的PEO链的官能化末端具有反应性。 这些PEO涂层能够以最小的蛋白质损失或细胞排斥能力在环氧乙烷灭菌程序中存活。

    HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS
    9.
    发明公开
    HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS 有权
    通过使用高折光指数眼科装置材料，

    公开(公告)号：EP1080382A1

    公开(公告)日：2001-03-07

    申请号：EP99916343.9

    申请日：1999-04-01

    Applicant: Alcon Laboratories, Inc.

    Inventor： FREEMAN, Charles ,  JINKERSON, David, L. ,  KARAKELLE, Mutlu ,  LEBOEUF, Albert, R.

    IPC: G02B1/04 ,  A61L27/00

    CPC classification number: G02B1/043 ,  C08L33/14 ,  C08L33/06

    Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a) two or more monomers of structure (I), wherein X is H or CH3; m is 0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1(n=1-10), iso-OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with H, CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5; and b) a total of about 5 mole % or less of one or more monomers of structure (II), wherein X is H or CH3; W is -CH3 or (CH2=C(-X)-C(=O)-); and n is such that the weight average molecular weight is approximately 600-1000 if W is -CH3 and approximately 400-1000 if W is (CH2=C(-X)-C(=O)-).

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