公开(公告)号：WO1997010236A1

公开(公告)日：1997-03-20

申请号：PCT/US1996011821

申请日：1996-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  HELLBERG, Mark, R. ,  DELGADO, Pete ,  NIXON, Jon, C.

IPC: C07D307/80

CPC classification number: C07D307/79 ,  C07D307/80 ,  C07D311/72 ,  Y10S514/914

Abstract: Compounds having anti-inflammatory and anti-oxydant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.

Abstract translation: 公开了具有抗炎和抗氧化活性的化合物。 该化合物可用于通过几种机制预防和治疗炎症性疾病。 公开了使用这些化合物和相应药物组合物性质的治疗方法。

公开(公告)号：WO1995033457A1

公开(公告)日：1995-12-14

申请号：PCT/US1995007187

申请日：1995-06-06

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YANNI, John, M. ,  GRAFF, Gustav ,  HELLBERG, Mark, R.

IPC: A61K31/165

CPC classification number: C07C237/20 ,  A61K31/165 ,  A61K31/215 ,  C07C233/33 ,  C07C323/60

Abstract: Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.

Abstract translation: 公开了3-苯甲酰基苯乙酸的新型酯和酰胺衍生物。 还公开了这些新型衍生物和某些已知衍生物在局部给药组合物中用于治疗眼部炎症性疾病的用途。

公开(公告)号：WO1996041805A1

公开(公告)日：1996-12-27

申请号：PCT/US1995007528

申请日：1995-06-12

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  HELLBERG, Mark, R. ,  BARNES, George ,  COLLIER, Robert, J., Jr.

IPC: C07D405/12

CPC classification number: C07D405/12

Abstract: Compounds of formula (I) or (II) having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed. A = antioxidant having therapeutically significant free radical scavenging activity.

Abstract translation: 公开了具有钙拮抗剂和抗氧化活性的式（I）或（II）化合物。 该化合物可用于预防或减轻对细胞水平的组织的损伤。 还公开了使用化合物和相应药物组合物的这些性质的治疗方法。 A =具有治疗上显着的自由基清除活性的抗氧化剂。

公开(公告)号：WO1996010407A1

公开(公告)日：1996-04-11

申请号：PCT/US1995012171

申请日：1995-09-25

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  HELLBERG, Mark, R. ,  DEAN, Thomas, R. ,  ZINKE, Paul, W. ,  SELLIAH, Robert, D. ,  BISHOP, John, E.

IPC: A61K31/557

CPC classification number: A61K31/5575 ,  C07C405/00 ,  C07C405/0016

Abstract: Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

Abstract translation: 公开了可用于治疗青光眼和高眼压症的9-脱氧前列腺素。 这些9-脱氧前列腺素中的一些是新颖的。 还公开了包含这种前列腺素的眼科药物组合物。

公开(公告)号：EP1039895A1

公开(公告)日：2000-10-04

申请号：EP98960732.0

申请日：1998-12-04

Applicant: ALCON LABORATORIES, INC.

Inventor： YANNI, John, M. ,  HELLBERG, Mark, R.

IPC: A61K31/215 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195

CPC classification number: A61K31/215 ,  Y10S514/913

Abstract: Compositions of 3-benzoylphenylacetic acid derivatives for treating GLC1A glaucoma and methods for their use are disclosed.

公开(公告)号：EP1126850A1

公开(公告)日：2001-08-29

申请号：EP99957471.8

申请日：1999-10-20

Applicant: ALCON LABORATORIES, INC.

Inventor： COLLIER, Robert, J., Jr. ,  HELLBERG, Mark, R. ,  KAPIN, Michael, A. ,  BARNES, George, E. ,  CHANDLER, Michael, L.

IPC: A61K31/445

CPC classification number: A61K31/00 ,  A61K31/445 ,  Y10S514/912

Abstract: Compositions and methods for treating disorders of the outer retina with glutamate antagonists are disclosed.

公开(公告)号：EP0859769A1

公开(公告)日：1998-08-26

申请号：EP96924562.0

申请日：1996-07-17

Applicant: ALCON LABORATORIES, INC.

Inventor： HELLBERG, Mark, R. ,  DELGADO, Pete ,  NIXON, Jon, C.

IPC: A61K31 ,  A61P29 ,  A61P43 ,  C07D307 ,  C07D311

CPC classification number: C07D307/79 ,  C07D307/80 ,  C07D311/72 ,  Y10S514/914

Abstract: Compounds having anti-inflammatory and anti-oxydant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.

公开(公告)号：EP1039895B1

公开(公告)日：2002-06-05

申请号：EP98960732.0

申请日：1998-12-04

Applicant: ALCON LABORATORIES, INC.

Inventor： YANNI, John, M. ,  HELLBERG, Mark, R.

IPC: A61K31/215 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61P27/06

CPC classification number: A61K31/215 ,  Y10S514/913

Abstract: Compositions of 3-benzoylphenylacetic acid derivatives for treating GLC1A glaucoma and methods for their use are disclosed.

公开(公告)号：EP0716600B1

公开(公告)日：2002-04-03

申请号：EP95923733.0

申请日：1995-06-06

Applicant: ALCON LABORATORIES, INC.

Inventor： YANNI, John, M. ,  GRAFF, Gustav ,  HELLBERG, Mark, R.

IPC: A61K31/165 ,  A61P27/02 ,  A61P29/00

CPC classification number: C07C237/20 ,  A61K31/165 ,  A61K31/215 ,  C07C233/33 ,  C07C323/60

Abstract: Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.

公开(公告)号：EP0968183A2

公开(公告)日：2000-01-05

申请号：EP98911516.7

申请日：1998-03-06

Applicant: ALCON LABORATORIES, INC.

Inventor： ZINKE, Paul, W. ,  HELLBERG, Mark, R.

IPC: C07C405/00

CPC classification number: C07C405/0033

Abstract: 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.