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公开(公告)号：NO970163L
公开(公告)日：1997-03-14
申请号：NO970163
申请日：1997-01-14
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MUELLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/415 , A61K31/44 , C07D233/84 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61K31/445 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/73 , C07D213/79 , C07D213/81 , C07D233/90 , C07D307/79 , C07D333/24 , C07D333/28 , C07D333/38 , C07D471/18
Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：HU211658A9
公开(公告)日：1995-12-28
申请号：HU9500710
申请日：1995-06-30
Applicant: BASF AG
Inventor： BACH ALFRED , STRUBE KARL-HERMANN , KOERWER WOLFGANG
IPC: A61K38/36 , A61K38/46 , A61K38/48 , A61P7/02 , A61P13/02 , A61P15/00 , C07K14/46 , C07K14/75 , C12N1/00 , C12N1/15 , C12N1/21 , C12N5/22 , C12N9/50 , C12N9/64 , C12N15/09 , C12N15/12 , C12N15/57 , C12N15/70 , C12N15/81 , C12N15/85 , C12R1/19 , C12R1/91
Abstract: PCT No. PCT/EP89/01427 Sec. 371 Date May 14, 1991 Sec. 102(e) Date May 14, 1991 PCT Filed Nov. 25, 1989 PCT Pub. No. WO90/06362 PCT Pub. Date Jun. 14, 1990Pure glycosylated, partially glycosylated or unglycosylated polypeptides have the amino-acid sequence of ancrod, in which up to 5 amino acid residues can be replaced by residues of other natural amino acids, and are suitable for controlling diseases.
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公开(公告)号：DE59510596D1
公开(公告)日：2003-04-24
申请号：DE59510596
申请日：1995-07-14
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , RENDENBACH-MUELLER BEATRICE , BACH ALFRED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D277/22 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/54 , C07D277/20 , C07D277/32 , C07D277/36 , C07D277/42 , C07D285/12 , C07D285/125 , C07D285/135 , C07D417/12
Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.
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64.发明专利
公开(公告)号：SK283039B6
公开(公告)日：2003-02-04
申请号：SK23099
申请日：1997-08-22
Applicant: BASF AG
Inventor： STEINER GERD , LUBISCH WILFRIED , BACH ALFRED , EMLING FRANZ , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , BEHL BERTHOLD , KERRRIGAN FRANK , CHEETHAM SHARON
IPC: A61K31/435 , A61K31/519 , A61P25/24 , A61P43/00 , C07D211/00 , C07D239/00 , C07D333/00 , C07D495/14
Abstract: The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro- pyrid3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I), their physiologically acceptable salts and use in the therapy.
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65.发明专利
公开(公告)号：SI1025100T1
公开(公告)日：2002-10-31
申请号：SI9830101
申请日：1998-10-05
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , DULLWEBER UTA , STARCK DOROTHEA , STEINER GERD , BACH ALFRED , EMLING FRANZ , GARCIA-LADONA XAVIER , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D471/00
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Patent Agency Ranking66.发明专利
公开(公告)号：AU749320B2
公开(公告)日：2002-06-20
申请号：AU7917698
申请日：1998-05-29
Applicant: BASF AG
Inventor： STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , GARCIA-LADONA FRANCISCO-JAVIER , EMLING FRANZ
IPC: A61K31/495 , A61K31/519 , A61P25/00 , A61P25/24 , A61P43/00 , C07D495/04
Abstract: PCT No. PCT/EP98/03230 Sec. 371 Date Dec. 6, 1999 Sec. 102(e) Date Dec. 6, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56792 PCT Pub. Date Dec. 17, 19983-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the formula I where R1 and R2 are a hydrogen atom or a C1-C4-alkyl group, R3 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which may be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups, and may contain 1 nitrogen atom, or to a 5- or 6-membered ring, which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it being possible for the linkage between Y and Z also to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.
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公开(公告)号：DE59802922D1
公开(公告)日：2002-03-14
申请号：DE59802922
申请日：1998-10-05
Applicant: BASF AG
Inventor： LUBISCH WILFRIED , DULLWEBER UTA , STARCK DOROTHEA , STEINER GERD , BACH ALFRED , EMLING FRANZ , GARCIA-LADONA XAVIER , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/519 , A61P1/00 , A61P1/14 , A61P3/04 , A61P5/00 , A61P9/12 , A61P15/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/00 , C07D471/04
Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.
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公开(公告)号：CA2083286C
公开(公告)日：2001-11-27
申请号：CA2083286
申请日：1991-07-19
Applicant: BASF AG
Inventor： BACH ALFRED , HILLEN HEINZ , BIALOJAN SIEGFRIED
IPC: A61K38/00 , A61K35/76 , A61K38/46 , A61P7/02 , A61P13/02 , A61P15/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/12 , C12N15/31 , C12N15/57 , A61K38/48
Abstract: Glycosylated, partially glycosylated and non-glycosylated polypeptides which have the amino-acid sequences indicated in the sequence listing and in which up to 10 amino-acid residues can be replaced by residues of other natural amino acids are described. The peptides are suitable for controlling diseases.
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公开(公告)号：HU0101311A2
公开(公告)日：2001-09-28
申请号：HU0101311
申请日：1998-07-23
Applicant: BASF AG
Inventor： BACH ALFRED , DULLWEBER UTA , EMLING FRANZ , GARCIA-LADONA XAVIER , STARCK DOROTHEA , STEINER GERD , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/435 , A61P25/24 , C07D495/14
Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.
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公开(公告)号：CZ288896B6
公开(公告)日：2001-09-12
申请号：CZ75999
申请日：1997-08-22
Applicant: BASF AG
Inventor： STEINER GERD , LUBISCH WILFRIED , BACH ALFRED , EMLING FRANZ , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , BEHL BERTHOLD , CHEETHAM SHARON , KERRRIGAN FRANK
IPC: A61K31/435 , A61K31/519 , A61P25/24 , A61P43/00 , C07D211/00 , C07D239/00 , C07D333/00 , C07D495/14 , A61K31/4365 , A61K31/40
Abstract: In the present invention there are disclosed 3-substituted pyrido 3,4,5,6,7,8-hexahydro-pyrido (4 ,3 :4,5)thieno(2,3-d) pyrimidine derivatives of the general formula I, wherein the substituents have specific meanings and their salts with physiologically acceptable acids. These compounds are used for preparing medicaments intended for treating depressions and for inhibiting back absorption of serotonin. They are also used as selective antagonists.
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