公开(公告)号：CZ20012373A3

公开(公告)日：2002-05-15

申请号：CZ20012373

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：CO5130037A1

公开(公告)日：2002-02-27

申请号：CO99051371

申请日：1999-08-12

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER UNGER ,  TESCHENDORF HANS-JURGEN ,  FRIEDER JUCHELKA

IPC: A61K31/395 ,  A61K31/415 ,  A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: Derivados de 3-azabiciclo-[3.2.0]heptano N-sustituidos de la fórmula I En donde R1 significa flúor o cloro,R2 significa alquilo con 1 a 3 átomos de carbono o ciclopropilo, yR3 significa hidrógeno, flúor o cloro,y sus sales con ácidos fisiológicamente tolerados.

公开(公告)号：CO5130024A1

公开(公告)日：2002-02-27

申请号：CO99051370

申请日：1999-08-12

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER UNGER ,  TESCHENDORF HANS-JURGEN ,  FRIEDER JUCHELKA

IPC: A61K31/395 ,  A61K31/425 ,  A61K31/428 ,  A61K31/54 ,  A61P25/00 ,  C07D417/06

Abstract: Derivados de 3-azabiciclo-[3.2.0]heptano N-sustituidos de la fórmula I En dondeR1 significa flúor o cloro,R2 y R3 significa hidrógeno o alquilo con 1 a 3 átomos de carbono y R4 significa cloro, metilo, nitro, o amino,y sus sales con ácidos fisiológicamente tolerados.

公开(公告)号：SK7142001A3

公开(公告)日：2001-12-03

申请号：SK7142001

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：CO5070700A1

公开(公告)日：2001-08-28

申请号：CO99034565

申请日：1999-06-02

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  OTTERBACH BERND ,  BURKHARD KROGER ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/52 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53

Abstract: Una homóloga de la poli(ADP-ribosa) polimerasa (PARP) caracterizada porque posee una secuencia de aminoácidos que posee:a) un dominio funcional de unión con NAD+ yb) ningún patrón de secuencia tipo dedo de zinc de fórmula general CX2 CXm HX2 CEn el cualm es un número entero entre 28 y 30, y los radicales X son, independientemente uno del otro, aminoácidos cualesquiera; y los equivalentes funcionales de los mismos.

公开(公告)号：CZ20011724A3

公开(公告)日：2001-08-15

申请号：CZ20011724

申请日：1999-11-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS

IPC: C07D235/18 ,  A61K20060101 ,  A61K31/10 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/454 ,  A61P20060101 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P13/12 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D20060101 ,  C07D209/14 ,  C07D235/04

Abstract: 2-Phenylbenzimidazoles and 2-phenylindoles of formula IwhereinA is N or CH,R1 is hydrogen or alkyl which optionally carries an OR11 group,R11 is hydrogen or alkyl,R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH-CO-R23, OR21,R21 and R22 are each hydrogen or alkyl,R23 is hydrogen, alkyl or phenyl,R3 is -(CH2)q-NR31R32,q is 0, 1, 2 or 3,R31 is hydrogen, alkyl, (CH2)rNR33R34,R32 is (CH2)rNR33R34,r is 2, 3, 4, 5 or 6,R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, orR33 and R34 and the nitrogen atom form a 3- to 8-membered ring,R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH-CO-R43, OR41,R41 and R42 are each hydrogen or alkyl, andR43 is alkyl or phenyl,are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.

公开(公告)号：AU4054201A

公开(公告)日：2001-08-14

申请号：AU4054201

申请日：2001-01-25

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: C07D471/04 ,  A61K31/437 ,  A61P25/00

Abstract: The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.

公开(公告)号：SK812001A3

公开(公告)日：2001-08-06

申请号：SK812001

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：SK1382001A3

公开(公告)日：2001-08-06

申请号：SK1382001

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06

Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.

公开(公告)号：ES2148476T3

公开(公告)日：2000-10-16

申请号：ES95903284

申请日：1994-11-26

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  HOGER THOMAS

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/14 ,  C07D209/18 ,  C07D209/44 ,  C07D209/52 ,  C07D487/04 ,  C07D491/048 ,  C07D497/04

Abstract: PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.