公开(公告)号：WO9964572A3

公开(公告)日：2000-06-08

申请号：PCT/EP9903889

申请日：1999-06-04

Applicant: BASF AG ,  KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS GEORG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  A61K31/70 ,  C12N15/10

CPC classification number: C12N9/1077 ,  A01K2217/05 ,  A61K38/00 ,  A61K49/00 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12Q1/48 ,  C12Y204/0203 ,  G01N2333/91142

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD -binding site and b) no zinc-finger-sequence motif of general formula CX2CXmHX2C, wherein m is an integral number 28 or 30 and the radicals X represent any amino acid, independently of each other; and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acids coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type.

Abstract translation: 本发明涉及聚（ADP-核糖）聚合酶（PARP）的同系物，其特征在于包括的氨基酸序列的）功能性NAD <+> - 结合结构域和b）通式的无锌指基序：CX2CXmHX2C具有，其中 m为28或30的整数，并且基团X独立地是任意氨基酸; 和其功能等价物; 核酸编码; 具有特异性的新型蛋白质的抗体; 包含根据本发明的产品的药物和基因治疗的组合物; 一种用于分析测定本发明的蛋白质和核酸的方法; 一种用于鉴定效应或结合本发明的蛋白质的方法伙伴; 新颖PARP效应; 和用于确定这种效应物的有效性的方法。

公开(公告)号：BG105018A

公开(公告)日：2001-12-31

申请号：BG10501800

申请日：2000-12-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  A61K31/00

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD+-binding site, and b) no zinc-finger-sequence motif of general formula CX2CHmHX2C, wherein m is an integral number of 28 or 30 and the radicals X represent any amino acid, independently of each other; and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acid coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type. 32 claims

公开(公告)号：CA2330206A1

公开(公告)日：1999-12-16

申请号：CA2330206

申请日：1999-06-04

Applicant: BASF AG

Inventor： HOGER THOMAS ,  KOCK MICHAEL ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD+-binding site and b) no zinc-finger-sequence motif of general formula CX2CXmHX2C, wherein m is an integral number 28 or 30 and the radicals X represent any amino acid, independently of each other; and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acids coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type.

公开(公告)号：CO5070700A1

公开(公告)日：2001-08-28

申请号：CO99034565

申请日：1999-06-02

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  OTTERBACH BERND ,  BURKHARD KROGER ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N15/09 ,  C12N15/52 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53

Abstract: Una homóloga de la poli(ADP-ribosa) polimerasa (PARP) caracterizada porque posee una secuencia de aminoácidos que posee:a) un dominio funcional de unión con NAD+ yb) ningún patrón de secuencia tipo dedo de zinc de fórmula general CX2 CXm HX2 CEn el cualm es un número entero entre 28 y 30, y los radicales X son, independientemente uno del otro, aminoácidos cualesquiera; y los equivalentes funcionales de los mismos.

公开(公告)号：NO20006153D0

公开(公告)日：2000-12-04

申请号：NO20006153

申请日：2000-12-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：HU0103190A2

公开(公告)日：2001-12-28

申请号：HU0103190

申请日：1999-06-04

Applicant: BASF AG

Inventor： HOEGER THOMAS ,  KOCK MICHAEL ,  KROEGER BURKHARD ,  LEMAIRE HANS-GEORG ,  LUBISCH WILFRIED ,  OTTERBACH BERND

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：SK17892000A3

公开(公告)日：2001-09-11

申请号：SK17892000

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：NO20006153L

公开(公告)日：2001-02-02

申请号：NO20006153

申请日：2000-12-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：ZA200100084B

公开(公告)日：2002-01-04

申请号：ZA200100084

申请日：2001-01-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K20060101 ,  A61K20060101 ,  C07K20060101 ,  C12N20060101 ,  C12Q20060101 ,  G01N20060101 ,  C12N ,  A01K ,  A61K ,  C07K ,  C12Q ,  G01N

公开(公告)号：CZ20004536A3

公开(公告)日：2001-06-13

申请号：CZ20004536

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOEGER THOMAS ,  KROEGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  A61K31/70 ,  A61K38/45 ,  A61K48/00 ,  C07K14/455 ,  C12N9/10 ,  C12N15/10 ,  C12N15/54 ,  C12Q1/6804 ,  G01N33/53 ,  C12Q1/68