公开(公告)号：DE4019052A1

公开(公告)日：1991-12-19

申请号：DE4019052

申请日：1990-06-15

Applicant: BASF AG

Inventor： KOEHLER GERNOT DR ,  KLIMESCH ROGER DR

IPC: B01J20/26 ,  B01J39/04 ,  B01J39/20 ,  C02F1/42 ,  C02F1/44 ,  C02F1/62 ,  C08F8/44 ,  C08F210/02

Abstract: A process is claimed for removing or concentrating heavy metal ions (I) from aq. soln. by bringing the aq. soln. into contact with a copolymer (II) of ethylene, (meth)acrylic acid and (meth)acrylate ester in which up to 100% of the COOH gps. can be neutralised with metal ions. - (II) is a copolymer of 40-87 wt.% ethylene, 6-25 wt.% (meth)acrylic acid, 2-30 wt.% (meth)acrylate ester and 5-25 wt.% alkylpolyglycol (meth)acrylate; the COOH gps. in (II) are neutralised with Na, K, Mg or Ca ions; (II) is in the form of granules, in which case (I) are removed by passing through a chromatography column contg. (I), or film in which case (I) are conc. by bringing the soln. into contact with the film. - Pref. comonomers are 40-75 wt.% ethylene, 6-20 wt.% (meth)acrylic acid, 5-20 wt.% n-butyl, 2-ethylhexyl or lauryl acrylate and 5-20 wt.% acrylate of methyl-PEG 400, 460 or 660; adsorbed (I) can be recovered by elution with e.g. aq. NaCl, KCl, dil, HCl, etc.

公开(公告)号：DE4019050A1

公开(公告)日：1991-12-19

申请号：DE4019050

申请日：1990-06-15

Applicant: BASF AG

Inventor： KOEHLER GERNOT DR ,  KLIMESCH ROGER DR

IPC: B01J20/26 ,  B01J39/04 ,  B01J39/20 ,  C02F1/42 ,  C02F1/44 ,  C02F1/62 ,  C08F8/44 ,  C08F210/02

Abstract: A process is claimed for removing or concentrating heavy metal ions (I) from aq. soln. by bringing the aq. soln. into contact with a copoolymer (II) of ethylene, (meth)acrylic acid and (meth)acrylate ester in which up to 100% of the COOH gps. can be neutralised with metal ions. (II) is a copolymer of 40-87 wt.% ethylene, 6-25 wt.% (meth)acrylic acid, 2-30 wt.% (meth)acrylate ester and 5-25 wt.% alkylpolyglycol (meth)acrylate; the COOH gps. in (II) are neutralised with Na, K, Mg or Ca ions; (II) is in the form of granules, in which case (I) are removed by passing through a chromatography column contg. (I), or film in which case (I) are conc. by bringing the soln. into contact with the film. Pref. comonomers are 40-75 wt.% ethylene, 6-20 wt.% (meth)acrylic acid, 5-20 wt.% n-butyl, 2-ethylhexyl or lauryl acrylate and 5-20 wt.% acrylate of methyl-PEG 400, 460 or 660; adsorbed (I) can be recovered by elution with e.g. aq. NaCl, KCl, dil, HCl, etc.

公开(公告)号：DE3919659A1

公开(公告)日：1990-12-20

申请号：DE3919659

申请日：1989-06-16

Applicant: BASF AG

Inventor： KLIMESCH ROGER DR ,  KOEHLER GERNOT DR ,  SCHLEMMER LOTHAR

IPC: C02F3/10 ,  A01N25/10 ,  C08J3/20 ,  C08K5/15 ,  C08K5/151 ,  C08K5/1545 ,  C08L1/00 ,  C08L3/00 ,  C08L3/02 ,  C08L5/00 ,  C08L23/08

公开(公告)号：DE3830353A1

公开(公告)日：1990-03-15

申请号：DE3830353

申请日：1988-09-07

Applicant: BASF AG

Inventor： KLIMESCH ROGER DR ,  BLECKMANN GERHARD ,  FARWERCK KARL-PETER ,  SCHLEMMER LOTHAR ,  SANNER AXEL DR

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/00 ,  B30B11/16

Abstract: Method for tabletting a mixture of at least one pharmaceutical agent and at least one thermoplastic polymer, characterised in that the mixture is extruded and the still deformable extrudate is compressed between two belts which are in contact in sections, are rotating in opposite directions and running parallel over the contact section, or between a belt and a roller, to give tablets, where the shaping depressions, which are mutually complementary in pairs where appropriate, are provided in both or only in one of the rotating shaping elements.

公开(公告)号：DE3810343A1

公开(公告)日：1989-10-05

申请号：DE3810343

申请日：1988-03-26

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER DR ,  LANG SIEGFRIED DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR ,  SCHLEMMER LOTHAR

IPC: A61K9/20 ,  A61K9/22

Abstract: Process for the production of solid pharmaceutical sustained release forms which contain as binder a polymer which dissolves or disperses in water and gastric or intestinal fluid, wherein the pharmaceutical agent, the polymeric binder and, where appropriate, the pharmaceutical ancillary substances are mixed below the glass transition temperature of the binder, this mixture is compressed, above the glass transition temperature of the binder but below the decomposition temperature of the agent, to pharmaceutical forms, and the form is removed from the mould at a temperature below the glass transition temperature of the binder, and where the type and amount of the binder and ancillary substance are chosen so that the release of agent is sustained for a period of 3 to 24 hours.

公开(公告)号：DE3612212A1

公开(公告)日：1987-10-15

申请号：DE3612212

申请日：1986-04-11

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER DR ,  LAEMMERHIRT KLAUS DR ,  LANG SIEGFRIED DR ,  SPENGLER REINHARD DR ,  SANNER AXEL DR

IPC: A61K47/32 ,  A61J3/06 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/00 ,  A61J3/00 ,  C08L39/06

Abstract: Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50 DEG to 180 DEG C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.