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公开(公告)号：CZ9603713A3
公开(公告)日：1997-10-15
申请号：CZ371396
申请日：1995-06-06
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
CPC classification number: C07K5/0812 , A61K38/00 , A61K47/64 , C07D205/04 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/06113
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公开(公告)号：NO972559L
公开(公告)日：1997-08-05
申请号：NO972559
申请日：1997-06-05
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , ZIERKE THOMAS
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63.发明专利
公开(公告)号：ZA9510295B
公开(公告)日：1997-06-05
申请号：ZA9510295
申请日：1995-12-05
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , ZIERKE THOMAS
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公开(公告)号：NO972559D0
公开(公告)日：1997-06-05
申请号：NO972559
申请日：1997-06-05
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , ZIERKE THOMAS
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公开(公告)号：FI965039A
公开(公告)日：1997-02-14
申请号：FI965039
申请日：1996-12-16
Applicant: BASF AG
Inventor： BUEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078 , C07K
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：HRP960075B1
公开(公告)日：2004-10-31
申请号：HRP960075
申请日：1996-02-15
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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公开(公告)号：PL355111A1
公开(公告)日：2004-04-05
申请号：PL35511100
申请日：2000-07-11
Applicant: BASF AG
Inventor： KNOPP MONIKA , KOSER STEFAN , SCHAFER BERND
IPC: C07D277/20 , C07D277/56
Abstract: The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ibin whichn=1 or 2 andfor n=1, X is chloride, bromide, triflate and hydrogen sulfate andfor n=2, X is sulfate, which comprises the process step where the aminonitrile of the formula IIis stirred with a cysteine ester of the formula III,in which R is branched or linear C1-10-alkyl orwhere n=0, 1 or 2 and R is branched or linear C1-C10C10-alkyl or C1-C4-alkoxy or C1-C4-dialkylamino in an inert solvent in the presence of a base at from 0° C. to 80° C. until the reaction has essentially proceeded to completion, and to the compounds of the formulae Ia and Ib.
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公开(公告)号：DE59510645D1
公开(公告)日：2003-05-22
申请号：DE59510645
申请日：1995-06-06
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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公开(公告)号：BG106332A
公开(公告)日：2002-08-30
申请号：BG10633202
申请日：2002-01-21
Applicant: BASF AG
Inventor： KNOPP MONIKA , KOSER STEFAN , SCHAEFER BERND
IPC: C07D277/20 , C07D277/56
Abstract: The present invention relates to a method for producing 4-cyano-2-amino-methyl-4-cyano thiazol, including a step in which an aminonitrile is stirred with a cystein ester. 10 claims
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公开(公告)号：EA002767B1
公开(公告)日：2002-08-29
申请号：EA199700155
申请日：1996-02-06
Applicant: BASF AG
Inventor： SEITZ WERNER , MACK HELMUT , ZIERKE THOMAS , BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , KOSER STEFAN , PFEIFFER THOMAS , HORNBERGER WILFRIED
Abstract: Описываютсяингибиторытромбинаформулы (I)где R, А, Ви D имеютуказанныев п.1 формулыизобретениязначения,иихстереоизомерыи ихсолис физиологическипереносимымикислотами, вкоторыхамидиноваяфункцияможетиметьсяв моно- илибис-защищеннойформе. Данныесоединениямогутприменятьсядлялеченияи профилактикиразличногородатромбинзависящихсобытий. Дополнительнымиобъектамиизобретенияявляютсясоединенияформул (VII) и (VIII)где R, А, Ви D имеютуказанноев п.1 формулыизобретениязначение, ив формуле (VII) амидиноваяфункцияможетиметьсяв моно- илибис-защищеннойформе,которыепредставляютсобойпромежуточныепродуктыдляполучениясоединенийформулы (I). Крометого, онипредставляютсобойценныевеществадлясинтезаингибиторовсеринпротеазы. Дальнейшимобъектомизобретенияявляетсяструктурныйфрагментформулы (IX)которыйпредставляетсобойценныйкомпонентингибиторовсеринпротеазы, ив частностиингибиторовтромбина.
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