公开(公告)号：WO1992019355A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003475

申请日：1992-04-27

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BUCHHOLZ, Donald, H. ,  KANDLER, Richard, L.

IPC: B01D37/00

CPC classification number: A61K35/18 ,  A61M1/0218 ,  A61M2202/0429 ,  A61M2205/7518 ,  A61M2202/0042 ,  A61M2202/005

Abstract: A blood processing method provides a red blood cell product that is free of microorganisms like Yersinia enterocolitica during storage periods over 24 hours. The red blood cell product is collected in a first container (16), where it is refrigerating to cool the blood product to a temperature of about 3 to 5 degrees C. The refrigerated product is transferred from the first container (16) into a storage container (34) through a prescribed filter medium (44) that comprises a mass of synthetic fibers having an average fiber diameter of about 10 microns or less and a bulk density of about 0.7 gram per cubic centimeter or less. The filtered product is retained in the storage container (34) at a temperature of about 3 to 5 degrees C for a storage period over 24 hours after filtration. Using the filter medium (44), microorganisms like Yersinia enterocolitica present in the red blood cell product at the time of collection are depleted. The filtered blood product remains free of clinically significant numbers of microorganisms throughout refrigerated storage up to time of transfusion.

Abstract translation: 血液处理方法提供在24小时内储存期间不含微生物如小肠结肠炎耶尔森菌的红细胞产物。 将红细胞产品收集在第一容器（16）中，在该第一容器（16）中，其被冷藏以将血液制品冷却至约3至5摄氏度的温度。冷藏产品从第一容器（16）转移到储存器 容器（34）通过规定的过滤介质（44），所述过滤介质包括大量的平均纤维直径约为10微米或更小，体积密度为约0.7克/立方厘米或更小的合成纤维。 过滤后的产物在约3〜5℃的温度下保存在储存容器（34）中24小时以上。 使用过滤介质（44），在收集时存在于红细胞产品中的微生物诸如肠球菌耶尔森菌（Yersinia enterocolitica）被耗尽。 过滤的血液制品在输血时间内，在冷藏保存期间，仍然无临床显着数量的微生物。

公开(公告)号：WO1992019284A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003422

申请日：1992-04-27

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GRIMM, Daniel, J. ,  LEUENBERGER, Mark, S.

IPC: A61L02/12

CPC classification number: A61L2/10 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1462 ,  A61J1/1468 ,  A61J1/1487 ,  A61J2205/10 ,  A61J2205/20 ,  A61J2205/30 ,  A61L2/0011 ,  Y10T436/12

Abstract: A container (10) for irradiation comprises a flexible, flat collapsible wall (12, 13) defining a sealed chamber (36), the plastic material of the wall (12, 13) is substantially transparent to irradiation, typically ultraviolet radiation. Access ports (22, 24, 26) are provided for communicating through the wall (12, 13) to the chamber (36). A flap (32) is provided, integral with the wall (12, 13) and spaced from the chamber (36), and carries identifying indicia (38) including a typical bar code indicia (40), so that the wall (12, 13) may be at least substantially free of opaque indicia. Also, structure may be provided for detecting and indicating exposure of the container to irradiation, such as ultraviolet sensitive tape (50) adhering to the flap (32). Alignment holes (46) may be provided, typically in the flap (32), to facilitate orientation of the container (10) with apparatus for irradiation (51) and apparatus for bar code reading (72), making use of alignment pins (70) carried by such apparatus (51).

Abstract translation: 用于照射的容器（10）包括限定密封室（36）的柔性的，平坦的可折叠壁（12,13），所述壁（12,13）的塑料材料对照射（通常为紫外线辐射）基本上是透明的。 提供进入端口（22,24,26）用于通过壁（12,13）连通到室（36）。 提供了一个与所述壁（12,13）成一体并且与所述室（36）间隔开的折板（32），并且携带包括典型条形码标记（40）的识别标记（38），使得所述壁 13）可以至少基本上不含不透明标记。 而且，可以提供用于检测和指示容器照射的结构，例如粘附到翼片（32）上的紫外线敏感带（50）。 通常可以在翼片（32）中设置对准孔（46），以便利用用于照射的装置（51）和用于条形码读取装置（72）的容器（10）的取向，利用对准销（70 ）由该装置（51）承载。

公开(公告)号：WO1992014496A2

公开(公告)日：1992-09-03

申请号：PCT/US1992001557

申请日：1992-02-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  TELANG, Anil, M. ,  McDOWELL, Douglas, J.

IPC: A61M01/00

CPC classification number: A61M1/0013 ,  A61G7/0503 ,  A61M1/0056 ,  A61M2202/0492 ,  A61M2209/082

Abstract: A system is described for the collection and re-infusion of fluids from a patient. The system includes a non-disposable rigid cannister (12) and a disposable flexible liner (22) that is placed in the cannister (12). Fluids are collected from a patient in the cannister liner (22). The liner (22) is then removed from the cannister (12) and the contents are re-infused back into a patient. The system is unique in that it provides a stand alone vacuum means for continuously providing a relatively high vacuum to the cannister (12) and a relatively low vacuum inside the liner (22) to cause the liner (22) to expand against the walls of the cannister (12). The stand alone vacuum means also provides a consistent relatively low vacuum to a patient's cavity for collecting fluids from the patient without damaging the patient's internal organs.

公开(公告)号：WO1992014448A1

公开(公告)日：1992-09-03

申请号：PCT/US1991008114

申请日：1991-10-30

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MARGALIT, Rimona

IPC: A61K09/127

CPC classification number: A61K9/1271

Abstract: Crosslinking reagents glutaraldehyde and ethylene glycol diglycidyl ether have been used to bind epidermal growth factor ("EGF") to liposomal surfaces without utilizing the disulfide bridge linkage of EGF and, therefore, not adversely affecting the functionality of EGF. The crosslinking occurs through the amine residues offered by EGF and liposomes having phosphatidylethanolamine. The resulting EGF-modified liposomes offer potential as a microscopic drug delivery system.

Abstract translation: 已经使用交联试剂戊二醛和乙二醇二缩水甘油醚将表皮生长因子（“EGF”）结合到脂质体表面，而不利用EGF的二硫键连接，因此不会不利地影响EGF的功能。 交联通过由EGF提供的胺残基和具有磷脂酰乙醇胺的脂质体发生。 所得到的EGF修饰的脂质体提供作为显微药物递送系统的潜力。

公开(公告)号：WO1992014446A1

公开(公告)日：1992-09-03

申请号：PCT/US1991008112

申请日：1991-10-30

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MARGALIT, Rimona ,  ROSEMAN, Theodore ,  WOOD, Ray, W.

IPC: A61K09/127

CPC classification number: A61K9/1271

Abstract: Recognizing substances, epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular target site. These "bioadhesive" liposomes offer several advantages in the area of topically and locally administered free drug. These advantages include the mutual protection of both the drug and biological environment; an increase in drug bioavailability and retention at the target site; and improved adherence or adhesion to the designated target site.

Abstract translation: 识别物质，表皮生长因子，明胶，胶原蛋白和透明质酸已经共价结合到脂质体表面，并用于将脂质体附着到细胞靶位点上。 这些“生物粘附”脂质体在局部和局部施用的游离药物领域提供了几个优点。 这些优点包括药物和生物环境的相互保护; 药物生物利用度的提高和目标地点的保留; 并改善对指定目标地点的粘附或粘附。

公开(公告)号：WO1992014445A1

公开(公告)日：1992-09-03

申请号：PCT/US1991008111

申请日：1991-10-30

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MARGALIT, Rimona

IPC: A61K09/127

CPC classification number: A61K9/1271 ,  C07C231/12 ,  C07C231/14 ,  C07C233/07 ,  C07C233/65 ,  C07C2602/10

Abstract: Drug-encapsulating liposomes have been successfully modified through the covalent binding of recognizing substances without significant interference with the rate constant of drug efflux from the liposomes. Through data processing according to two mechanisms, the acceptability of the bioadhesive liposomes as sustained release drug delivery systems for topical or local administration is shown.

Abstract translation: 已经通过识别物质的共价结合而不显着干扰来自脂质体的药物流出速率常数来成功修饰药物包封的脂质体。 通过根据两种机制的数据处理，显示生物粘附性脂质体作为用于局部或局部给药的缓释药物递送系统的可接受性。

公开(公告)号：WO1992012671A1

公开(公告)日：1992-08-06

申请号：PCT/US1992000172

申请日：1992-01-10

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BUCKLEY, Mary, Ellen

IPC: A61B05/103

CPC classification number: A61B5/1076 ,  A61F6/18

Abstract: A disposable uterine sound device (10) for measuring the depth and course of an uterine cavity is formed by coating a copper rod (14) and a portion of an attached nylon handle (12) with polyvinyl chloride. The coating (20) is then printed with a generally nonleachable biocompatible ink to form graduations (22) indicating units of measure of length. The resulting device is a flexible, smooth service device which minimizes trauma to a patient during use.

公开(公告)号：WO1992007525A1

公开(公告)日：1992-05-14

申请号：PCT/US1991007486

申请日：1991-10-10

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BRAUKER, James, H. ,  JOHNSON, Robert, C. ,  MARTINSON, Laura, A. ,  HILL, Ronald, S.

IPC: A61F02/00

CPC classification number: A61L29/085 ,  A61B5/14532 ,  A61B5/413 ,  A61F2/022 ,  A61L27/38 ,  A61L27/3839 ,  A61L27/56 ,  A61L29/005 ,  A61L29/146 ,  Y10S623/92 ,  Y10S623/925

Abstract: A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

Abstract translation: 一种用于植入在主体和装置之间的界面处的材料的主体的装置，所述材料具有导致主体靠近界面的血管结构生长的构象。

公开(公告)号：WO1992005814A1

公开(公告)日：1992-04-16

申请号：PCT/US1991007130

申请日：1991-09-27

Applicant: BAXTER INTERNATIONAL INC. ,  MILLIPORE CORPORATION

Inventor： BAXTER INTERNATIONAL INC. ,  MILLIPORE CORPORATION ,  SENNINGER, Mark ,  KENLEY, Rodney ,  WITSOE, David ,  BUCCHIANERI, Richard ,  DEMING, Laura ,  GARCIA, Ben

IPC: A61M01/14

CPC classification number: A61M1/1656 ,  A61M1/1668 ,  A61M1/287 ,  B01F3/088

Abstract: An apparatus (10) for proportioning solutions from at least first and second constituent solutions connected to separate inlet ports (26) of the apparatus (10) first detects which constituent solution is being supplied to which port and then properly proportions the finished solution from the constituent solutions irrespective of which constituent solution is connected to which inlet port.

Abstract translation: 用于将来自连接到装置（10）的分离的入口（26）的至少第一和第二组分溶液的溶液配比的装置（10）首先检测哪个构成溶液被供应到哪个端口，然后将成品溶液从 无论哪个成分溶液与哪个入口连接在一起。

公开(公告)号：WO1992003990A1

公开(公告)日：1992-03-19

申请号：PCT/US1991006255

申请日：1991-08-29

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  QUINTERO, Lillian, J. ,  COSGROVE, Delos, M. ,  NGUYEN-THIEN-NHON, Diana

IPC: A61F02/24

CPC classification number: A61F2/2427 ,  Y10S623/90

Abstract: A stentless aortic heart valve (13) having a disposable holder (55) with removable handle (71) attached can be manually reversed by the physician during suturing to provide a relatively unobstructed view into the patient's aorta. A covering (32) applied to strategic regions on the exterior and interior of the device provides a firm ground for suturing the prosthetic heart valve into position, and for attaching the detachable holder (55).