公开(公告)号：DK139428B

公开(公告)日：1979-02-19

申请号：DK271474

申请日：1974-05-17

Applicant: HOECHST AG

Inventor： KUNSTMANN R ,  GRANZER E

IPC: C07D221/16

Abstract: Partially hydrogenated 1H-indeno[1,2-b]-pyridine derivatives of the general formula I in which R1 and R2, which may be identical or different, represent hydrogen, halogen or alkoxy of 1 to 4 carbon atoms, R3 represents pyridyl, phenyl, or phenyl mono- or di-substituted by halogen, nitro, amino, acylamino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or amino substituted by 1 or 2 aliphatic or aromatic hydrocarbon groups having 2 to 18 carbon atoms or substituted amino wherein the amino-nitrogen is included in a heterocycle, A represents a single or double bond, and X represents oxygen or sulfur, AND THEIR PHYSIOLOGICALLY TOLERATED SALTS, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

公开(公告)号：PH12217A

公开(公告)日：1978-11-29

申请号：PH14710

申请日：1973-06-08

Applicant: HOECHST AG

Inventor： GRANZER E ,  MAUZ O

IPC: C07C59/52 ,  A61K31/00

Abstract: Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II wherein R1 and R2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

公开(公告)号：ZA775405B

公开(公告)日：1978-07-26

申请号：ZA775405

申请日：1977-09-07

Applicant: HOECHST AG

Inventor： GRANZER E ,  LANG H ,  KNABE B

IPC: A61K31/425 ,  A61K31/428 ,  A61P3/06 ,  C07C45/63 ,  C07C205/45 ,  C07D277/60 ,  C07D277/84 ,  C07D513/04 ,  C07D ,  A61K

Abstract: Thiazolidine derivatives of the formula I I in which the substituents R1 to R7 have the meanings as indicated in the following and which have in the free form or in the form of their non toxic acid addition salts valuable pharmaceutical properties, processes for preparing them, pharmaceutical preparations on the basis of these compounds and their use as medicines.

公开(公告)号：ZA775045B

公开(公告)日：1978-07-26

申请号：ZA775045

申请日：1977-08-19

Applicant: HOECHST AG

Inventor： HITZEL V ,  GRANZER E ,  WEYER R

IPC: C07D213/80 ,  C07D213/85 ,  C07D

公开(公告)号：SE7709905L

公开(公告)日：1978-03-05

申请号：SE7709905

申请日：1977-09-02

Applicant: HOECHST AG

Inventor： WEYER R ,  HITZEL V ,  GRANZER E

IPC: A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  C07C229/38 ,  C07C233/81 ,  C07C235/52 ,  C07D333/38 ,  C07C103/84

Abstract: Benzoic acids of the general formula I I in which R, R1, R2 and Y have the meanings as mentioned in the following, and which in the form of the free compounds or in the form of the physiologically tolerated salts and esters possess valuable pharmacological properties, processes for preparing them, pharmaceutical preparations containing them, and their use as or in medicaments.

公开(公告)号：SE7709905A

公开(公告)日：1978-03-05

申请号：SE7709905

申请日：1977-09-02

Applicant: HOECHST AG

Inventor： WEYER R ,  HITZEL V ,  GRANZER E

IPC: A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  C07C229/38 ,  C07C233/81 ,  C07C235/52 ,  C07D333/38 ,  C07C103/84

CPC classification number: C07C229/38 ,  C07D333/38

公开(公告)号：DK532376A

公开(公告)日：1976-11-25

申请号：DK532376

申请日：1976-11-25

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  GRANZER E ,  MUSIL J

IPC: C07C20060101 ,  C07C

公开(公告)号：SE7507096L

公开(公告)日：1975-12-22

申请号：SE7507096

申请日：1975-06-19

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  BECK G ,  GRANZER E

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66 ,  C07C131/00

Abstract: Procedure for the preparation of substituted 0-acyl acrylaldoximes of the formula I **(See formula)** where X represents a chlorine or bromine atom, R represents an alcoholic, alkoxy or alkylamino group, an alkenyl, alkenoxy or alkenylamino group each having 1 to 12 carbon atoms, or an aryl, aryloxy, arylalkyl group, arylalkoxy, arylamino or arylalkoxylaminos possibly substituted with one or two alcohol groups, each with 1 to 6 carbon atoms-, and R1, R2, R3 and R4 are the same or different and mean in each case a hydrogen atom, a halogen atom or an alcoholic or alkoxy group in each case with 1 to 6 carbon atoms, characterized in that the 2,3-diaryl-3-halogen-acryloxy compounds of formula II are acylated **(See formula)** wherein X, R1, R2, R3 and R4 have the meanings given in the description of formula I, in the presence of aprotic solvents with the aid of acylating agents, to form 0-acyl-2,3-diaryl-3- halogen-acryl-oximes of formula I. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：DK281175A

公开(公告)日：1975-12-22

申请号：DK281175

申请日：1975-06-20

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  BECK G ,  GRANZER E

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66 ,  C07C

Abstract: Procedure for the preparation of substituted 0-acyl acrylaldoximes of the formula I **(See formula)** where X represents a chlorine or bromine atom, R represents an alcoholic, alkoxy or alkylamino group, an alkenyl, alkenoxy or alkenylamino group each having 1 to 12 carbon atoms, or an aryl, aryloxy, arylalkyl group, arylalkoxy, arylamino or arylalkoxylaminos possibly substituted with one or two alcohol groups, each with 1 to 6 carbon atoms-, and R1, R2, R3 and R4 are the same or different and mean in each case a hydrogen atom, a halogen atom or an alcoholic or alkoxy group in each case with 1 to 6 carbon atoms, characterized in that the 2,3-diaryl-3-halogen-acryloxy compounds of formula II are acylated **(See formula)** wherein X, R1, R2, R3 and R4 have the meanings given in the description of formula I, in the presence of aprotic solvents with the aid of acylating agents, to form 0-acyl-2,3-diaryl-3- halogen-acryl-oximes of formula I. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：SE7502557L

公开(公告)日：1975-09-10

申请号：SE7502557

申请日：1975-03-07

Applicant: HOECHST AG

Inventor： TEUFEL H ,  BARTMANN W ,  GRANZER E ,  MUSIL J

IPC: C07C251/32 ,  A61K20060101 ,  A61K31/00 ,  A61K31/11 ,  A61K31/15 ,  A61K31/275 ,  C07C20060101 ,  C07C47/38 ,  C07C67/00 ,  C07C253/00 ,  C07C255/34 ,  C07C255/35 ,  C07C255/53 ,  C07C121/00

Abstract: 1489118 Derivatives of 1,2-diphenylethylene HOECHST AG 7 March 1975 [9 March 1974 22 Feb 1975] 9585/75 Heading C2C [Also in Division A5] The invention comprises compounds of formula wherein X is CN or CH = NOH, Hal is Cl or Br, and Ar and Ar 1 are each Ph possibly substituted by 1 or 2 of halogen atoms or C 1-6 alkyl or alkoxy groups, excepting the compounds where In examples, the oximes are prepared by reacting the corresponding aldehydes with NH 2 OH, and the nitriles by dehydrating the oximes. The excepted compounds are also prepared by these methods.