公开(公告)号：CA2089442C

公开(公告)日：2005-08-23

申请号：CA2089442

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  C07D401/12 ,  A61K31/40

Abstract: Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them Benzoylguanidines of the formula I are described in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH2)P- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, C1, alkyl, alkoxy, CF3, C m F2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.

公开(公告)号：PL179268B1

公开(公告)日：2000-08-31

申请号：PL32617094

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/64 ,  A61P9/00 ,  A61K31/18 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42 ,  A61K31/17

Abstract: There are described benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (fluoro)methyl, R(2) is H, Hal, (fluoro)(mercapto) alkyl(oxy), E is O, S; Y is -[CR(3)2]n- where R(3) = H or alkyl and n = 1 - 4, X is H, Hal, alkyl, Z is Hal, NO2, alkyl(oxy). The compounds (I) are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.

公开(公告)号：BR9705660A

公开(公告)日：1999-11-23

申请号：BR9705660

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: B05C17/02 ,  C07D311/70 ,  A61K31/64 ,  C07D405/12

公开(公告)号：PL330412A1

公开(公告)日：1999-05-10

申请号：PL33041297

申请日：1997-05-20

Applicant: HOECHST AG

Inventor： LANG HANS JOHEN ,  JANSEN HANS-WILLI ,  SCHWARK JAN-ROBERT ,  KLEEMANN HEINZ-WERNER ,  JUNG OLIVER ,  SCHAEFER HANS-LUDWIG ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

IPC: A61K31/155 ,  A61K31/00 ,  A61K31/166 ,  A61K31/22 ,  A61K31/255 ,  A61K31/365 ,  A61K31/41 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00

Abstract: The active substances identified as inhibitors of the cellular Na /H exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.

公开(公告)号：AU4515497A

公开(公告)日：1998-05-21

申请号：AU4515497

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D401/12 ,  C07D403/12

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：NO975214L

公开(公告)日：1998-05-15

申请号：NO975214

申请日：1997-11-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GAEGELEIN HEINZ ,  KLAUS ERIK

IPC: C07D311/04 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/40 ,  A61K31/4025 ,  A61P9/00 ,  A61P9/06 ,  C07D207/26 ,  C07D209/34 ,  C07D211/76 ,  C07D217/24 ,  C07D227/02 ,  C07D311/16 ,  C07D311/18 ,  C07D311/42 ,  C07D311/58 ,  C07D311/70 ,  C07D405/12 ,  C07D311/20

Abstract: 3-Amido-chromanylsulphonyl-urea or -thiourea derivatives of formula (I), in all stereoisomer (or mixture) forms, and their salts are new. R1 = H, alkyl, alkoxy, alkoxyalkoxy, alkylthio, F, Cl, Br, I or CF3; R2 = H, Me or Et; R3 = H or alkyl; Z = O or S; A = phenyl (optionally substituted by 1-3 halo, Me, Et, OMe or OEt), lactam residue of formula (i), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-perhydroisoquinolin-2-yl, 1-oxo-2,3-isoindolin-2-yl or 1-oxo-perhydroisoindolin-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); all alkyl moieties have 1-4C.

公开(公告)号：ZA9704828B

公开(公告)日：1997-12-03

申请号：ZA9704828

申请日：1997-06-02

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN ,  JANSEN HANS-WILLI ,  SCHWARK JAN-ROBERT ,  KLEEMANN HEINZ-WERNER ,  JUNG OLIVER ,  SCHAEFER HANS-LUDWIG ,  LINZ WOLFGANG ,  KRAMER WERNER ,  SCHOELKENS BERNWARD ,  FALK EUGEN

IPC: A61K31/155 ,  A61K31/00 ,  A61K31/166 ,  A61K31/22 ,  A61K31/255 ,  A61K31/365 ,  A61K31/41 ,  A61K31/455 ,  A61K45/00 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  A61K

CPC classification number: A61K31/166 ,  A61K31/00 ,  A61K31/155 ,  A61K31/22 ,  A61K31/365 ,  A61K31/165 ,  A61K2300/00

公开(公告)号：MX9606397A

公开(公告)日：1997-10-31

申请号：MX9606397

申请日：1996-12-13

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOGELEIN HEINZ ,  KLAUS ERIK ,  CRAUSE PETER

IPC: A61K31/35 ,  A61K31/352 ,  C07D311/58 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12 ,  C07D311/02 ,  A61K31/335

Abstract: Las cromanilsufonil(tio)ureas de formula I, son valiosos medicamentos para el tratamiento de trastornos del ritmo cardíaco y para prevenir la muerte cardíaca subita causada por arritmias. Pueden utilizarse como agentes antiarrítmicos, y son apropiadas para prevenir la muerte cardíaca subita, para el tratamiento de la insuficiencia cardíaca, y también del fracaso cardíaco en actuaciones de choque.

公开(公告)号：PL317397A1

公开(公告)日：1997-06-23

申请号：PL31739796

申请日：1996-12-09

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK ,  CRAUSE PETER

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  C07D311/58 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12 ,  A61K31/64

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.

公开(公告)号：ZA9610461B

公开(公告)日：1997-06-17

申请号：ZA9610461

申请日：1996-12-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  GERLACH UWE ,  MANIA DIETER ,  LINZ WOLFGANG ,  GOEGELEIN HEINZ ,  KLAUS ERIK ,  CRAUSE PETER

IPC: A61K31/35 ,  A61K31/352 ,  C07D311/58 ,  A61K31/353 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4412 ,  A61K31/443 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  C07D311/64 ,  C07D311/70 ,  C07D405/12 ,  C07D ,  A61K

Abstract: N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.