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    61.
    发明专利
    未知

    公开(公告)号：NO871602D0

    公开(公告)日：1987-04-15

    申请号：NO871602

    申请日：1987-04-15

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER ,  HAENEL HEINZ ,  RAETHER WOLFGANG ,  REUSCHLING DIETER ,  GROEBEL BENGT-THOMAS

    IPC: A61K31/44 ,  C07D213/89 ,  C07D309/38 ,  C07D213/00

    Abstract: New 1-hydroxy-2-pyridones of the general formula I I in which R1, R2 and R3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R1 and R3 preferably being hydrogen, and R2 preferably being methyl, X denotes S or, preferably, O, Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, Z denotes a single bond or the bivalent radicals O, S, -CR2- (R=H or C1-C4-alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C1-C4-alkyl groups, Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C1-C4-alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V V in which R1, R2, R3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.

    64.
    发明专利
    未知

    公开(公告)号：FI55331C

    公开(公告)日：1979-07-10

    申请号：FI89673

    申请日：1973-03-22

    Applicant: HOECHST AG

    Inventor： LOHAUS GERHARD ,  DITTMAR WALTER

    IPC: C07D221/04 ,  A61K31/4412 ,  A61P31/04 ,  C07D213/64 ,  C07D213/89 ,  C07D221/10 ,  C07D221/20 ,  C07D405/04 ,  C07D405/06 ,  C07D215/58

    Abstract: 1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.

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