公开(公告)号：US3687977A

公开(公告)日：1972-08-29

申请号：US3687977D

申请日：1969-09-05

Applicant: HOECHST AG

Inventor： RIPPEL ROBERT ,  DITTMAR WALTER ,  SCHORR MANFRED

IPC: C07D333/36 ,  C07D333/38 ,  A61K27/00 ,  C07D63/16

CPC classification number: C07D333/36 ,  C07D333/38

Abstract: Thiophene-3-isonitriles of the formula IN WHICH R1 is hydrogen, alkyl, carbalkoxy, cyano or phenyl, R2 is hydrogen, alkyl, alkoxy, carbalkoxy, cyano or phenyl, R3 is hydrogen, alkyl, carbalkoxy or phenyl, or R2 and R3 together represent an alkylene chain, are disclosed as having antimycotic and antibacterial properties.

Abstract translation: 噻吩-3-异腈，其中R1是氢，烷基，烷氧基，氰基或苯基，R2是氢，烷基，烷氧基，烷氧基，氰基或苯基，R3是氢，烷基，烷氧基或苯基，或R2和R3 一起表示亚烷基链，被公开为具有抗真菌性和抗菌性。

公开(公告)号：US3883545A

公开(公告)日：1975-05-13

申请号：US31738772

申请日：1972-12-22

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER

IPC: C07D213/89 ,  C07D31/30

CPC classification number: C07D213/89

Abstract: New 1-hydroxy-2-pyridones of the general formula
IN WHICH R1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or Alpha -furyl, all of which may be substituted by halogen and R2 to R4 are hydrogen or lower alkyl or 2 adjacent substituents together form a trimethylene or tetramethylene chain, and in which R1 to R4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated delta -keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization. The compounds exhibit antimycotic properties.

Abstract translation: 新的具有1至17个碳原子的烷基，5至8个碳原子的环烷基，环烷基或苯烷基，其中亚烷基链中具有1至3个碳原子的α-羟基-2-吡啶酮或α-呋喃基 所有这些可以被卤素取代，并且R 2至R 4是氢或低级烷基或2个相邻的取代基一起形成三亚甲基或四亚甲基链，并且其中R 1至R 4一起含有至少2个碳原子，通过使不饱和三 - 酯或其与羟胺的混合物，并使产物环化。

公开(公告)号：CA1339257C

公开(公告)日：1997-08-12

申请号：CA569578

申请日：1988-06-15

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  DITTMAR WALTER ,  KRAEMER KARL ,  PEIL HEINZ GEORG ,  FUTTERER EBERHARD

IPC: A61K31/41 ,  A61K8/00 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K9/70 ,  A61K31/13 ,  A61K31/135 ,  A61K31/27 ,  A61K31/325 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61Q3/02 ,  A61K7/043

Abstract: A nail lacquer containing at least one film-former which is insoluble in water and at least one substance which has antimycotic activity and is from the group comprising tioconazole, econazole, oxiconazole, miconazole, tolnaftate and naftifine hydrochloride.

公开(公告)号：DK170943B1

公开(公告)日：1996-03-25

申请号：DK326388

申请日：1988-06-15

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  DITTMAR WALTER ,  KRAEMER KARL ,  PEIL HEINZ GEORG ,  FUTTERER EBERHARD

IPC: A61K31/41 ,  A61K8/00 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K9/70 ,  A61K31/13 ,  A61K31/135 ,  A61K31/27 ,  A61K31/325 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61Q3/02 ,  A61K7/043

Abstract: The nail lacquer contains at least one water-insoluble film former and at least one antimycotic substance from the group comprising tioconazole, econazole, oxiconazole, miconazole, tolnaftate and naftifine hydrochloride.

公开(公告)号：AU589684B2

公开(公告)日：1989-10-19

申请号：AU6299986

申请日：1986-09-22

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  KAMPE KLAUS-DIETER ,  ALPERMANN HANS GEORG ,  GERHARDS HERMANN JOSEF ,  USINGER PATRICIA ,  SCHACHT ULRICH ,  LEVEN MARGRET ,  RAETHER WOLFGANG ,  DITTMAR WALTER ,  SACHSE BURKHARD

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00 ,  A61K31/445 ,  A61K31/535 ,  C07D405/06

Abstract: Arylmethylazoles of the formula I I in which Aryl is (substituted) phenyl or naphthyl; Z is CH or N; R1 and Q are H or alkyl; R2 is H, alk(en)yl or alkynyl; R3 and R4 are H, alkyl or other hydrocarbons; or R3 and R4 together are a -(CH2)2-11 chain or a bridged -(CH2)4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity. They are obtained, inter alia, from arylmethylazoles II II which are reacted with a strong base and then with a carbonyl compound III O=CR3R4; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R2Hal. If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

公开(公告)号：ES2005827A6

公开(公告)日：1989-04-01

申请号：ES8602070

申请日：1986-09-22

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  RAETHER WOLFGANG ,  DITTMAR WALTER

IPC: A01N43/50 ,  A01N43/653 ,  A01N45/02 ,  A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00

Abstract: PROCEDIMIENTO PARA LA PREPARACION DE ALQUENILAZOLES DE FORMULA: DONDE X E Y SON HIDROGENO, ALQUILO, FENILO, HALOGENO, ALCOXI O ALQUILTIO, Z ES CH O NITROGENO, R ES HIDROGENO, ALQUILO O METILENO, Y A ES ALQUILENO O UNA CADENA ALQUILENO PUENTEADA, ASI COMO SUS SALES, EN EL QUE SE SEPARA AGUA DE COMPUESTOS DE FORMULA DONDE X, Y, Z, R Y A SON COMO ANTES, MEDIANTE UN TRATAMIENTO DE 0,1 A 5 HORAS, A UNA TEMPERATURA DE 0-150JC, CON UN AGENTE DESHIDRATENTE ACIDO EN EXCESO DE 1 A 100 VECES, PRECIPITANDOSE EL COMPUESTO DE FORMULA I CON AGUA Y EXTRANYENDOSE CON UN DISOLVENTE NO MISCIBLE CON AGUA. LOS COMPUESTOS OBTENIDOS SON UTILES COMO ANTIMICOTICOS Y FUNGICIDAS.

公开(公告)号：DK326388D0

公开(公告)日：1988-06-15

申请号：DK326388

申请日：1988-06-15

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  DITTMAR WALTER ,  KRAEMER KARL ,  PEIL HEINZ GEORG ,  FUTTERER EBERHARD

IPC: A61K31/41 ,  A61K8/00 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61K9/70 ,  A61K31/13 ,  A61K31/135 ,  A61K31/27 ,  A61K31/325 ,  A61K31/415 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61Q3/02 ,  A61K9/00 ,  A61K7/043

Abstract: The nail lacquer contains at least one water-insoluble film former and at least one antimycotic substance from the group comprising tioconazole, econazole, oxiconazole, miconazole, tolnaftate and naftifine hydrochloride.

公开(公告)号：ZA872745B

公开(公告)日：1987-12-30

申请号：ZA872745

申请日：1987-04-16

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  GERHARD LOHAUS ,  RAETHER WOLFGANG ,  WOLFGANG RAETHER ,  DITTMAR WALTER ,  WALTER DITTMAR ,  REUSCHLING DIETER ,  DIETER REUSCHLING ,  HAENEL HEINZ ,  HEINZ HAENEL ,  GROEBEL BENGT-THOMAS ,  BENGT-THOMAS GROEBEL

IPC: A61K31/44 ,  A61K31/4418 ,  A61K31/445 ,  A61P17/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  C07D213/89 ,  C07D309/38 ,  C07D ,  A61K

公开(公告)号：HUT43829A

公开(公告)日：1987-12-28

申请号：HU110687

申请日：1987-03-13

Applicant: HOECHST AG

Inventor： EHRHARDT HEINZ ,  BLUME ERNST ,  RAETHER WOLFGANG ,  DITTMAR WALTER

IPC: C07C41/00 ,  A01N43/50 ,  A01N43/653 ,  A61K31/12 ,  A61K31/13 ,  A61K31/41 ,  A61K31/495 ,  C07C49/175 ,  C07C49/84 ,  C07C67/00 ,  C07C201/00 ,  C07C205/59 ,  C07C213/00 ,  C07D213/70 ,  C07D233/56 ,  C07D233/60 ,  C07D239/38 ,  C07D249/08 ,  C07D295/10 ,  C07D295/116 ,  C07D307/38 ,  C07D333/28 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C07D233/61 ,  A61K31/395

Abstract: Compounds I where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl, Z equals CO, CH2 or radicals of ketone derivatives; Y equals azole or equals -X-R8 (R8=(cyclo)alkyl or an aromatic) or equals a number of amine derivatives or equal acyl, are antimycotics. The preparation and use as medicaments are described.

公开(公告)号：HUT43828A

公开(公告)日：1987-12-28

申请号：HU110787

申请日：1987-03-13

Applicant: HOECHST AG

Inventor： BLUME ERNST ,  EHRHARDT HEINZ ,  DITTMAR WALTER ,  SACHSE BURKHARD ,  SCHAPER WOLFGANG ,  RAETHER WOLFGANG ,  HAENEL HEINZ

IPC: C07D247/00 ,  A01N43/50 ,  A01N43/653 ,  C07C41/00 ,  C07C43/18 ,  C07C67/00 ,  C07C201/00 ,  C07C213/00 ,  C07C215/42 ,  C07C217/48 ,  C07C217/74 ,  C07C253/00 ,  C07C255/54 ,  C07C313/00 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/20 ,  C07C323/22 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D307/38 ,  C07D333/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D521/00 ,  C07D233/54 ,  C07D403/08 ,  C07D405/08 ,  C07D409/08 ,  A61K31/395

Abstract: Compounds I I where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals -X-R1 where X=oxygen or sulfur and R1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals where R2 equals (cyclo)alkyl, acetyl or aryl; or Y equals -NR3R4 where R3/R4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II II with (CH3)2 III and further reaction of the compound IV obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.