公开(公告)号：ZA7903090B

公开(公告)日：1980-11-26

申请号：ZA7903090

申请日：1979-04-04

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  RYUICHI MITA ,  SAKAI KATSUYA ,  KATSUYA SAKAI ,  HIGUCHI CHOJIRO ,  CHOJIRO HIGUCHI ,  KATO TOSHIO ,  TOSHIO KATO ,  MURAKAMI HISAMICHI ,  HISAMICHI MURAKAMI

IPC: C07C20060101 ,  C07C

CPC classification number: Y02P20/582

公开(公告)号：DE69205076T2

公开(公告)日：1996-03-21

申请号：DE69205076

申请日：1992-06-26

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  SHIMUTA NOBUO ,  UEDA MAMORU ,  NAGATAKE YOSIRO ,  TAJIRI TOYOHIRO

IPC: C07C17/42 ,  C07C25/08

Abstract: A triethylene glycol derivative is added to p-dichlorobenzene so as to prevent consolidation and improve flowability of p-dichlorobenzene.

公开(公告)号：DE69007152T2

公开(公告)日：1994-07-14

申请号：DE69007152

申请日：1990-04-12

Applicant: MITSUI TOATSU CHEMICALS

Inventor： AKIEDA HIDEYUKI ,  SATO NAOKI ,  MORINAGA KOICHI ,  IDE YOSHINORI ,  MITA RYUICHI ,  UMEMOTO MITSUMASA

IPC: C07C41/16 ,  C07C43/29 ,  C07C43/225

Abstract: A higher yield of the difluorohalomethoxybenzene produced by the reaction of a metal phenolate with dibromodifluoromethane or bromochlorodifluoromethane can be obtained by conducting by the addition of a metal alcoholate or a metal hydride as a reaction initiator to a solution or a suspension of an aprotic polar solvent containing the metal phenolate and dibromodifluoromethane or bromochlorodifluoromethane.

公开(公告)号：DE3787082T2

公开(公告)日：1994-04-07

申请号：DE3787082

申请日：1987-12-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: C07K1/14 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075

Abstract: alpha -L-Aspartyl-L-phenylalanine methyl ester having low hygroscopicity is prepared by bringing a cake of alpha -L-aspartyl-L-phenylalanine methyl ester, which cake has been obtained by solid-liquid separation through a desired preparation process of alpha -L-aspartyl-L-phenyl-alanine methyl ester, into contact with an organic solvent of uniform phase so as to treat the cake with the organic solvent, subjecting the resulting mixture of the cake and organic solvent to solid-liquid separation to obtain a cake, and then drying the last-mentioned cake at a temperature not higher than 60 DEG C. The organic solvent is dry or contains water in an amount up to 30 wt.%.

公开(公告)号：ES2042583T3

公开(公告)日：1993-12-16

申请号：ES87310584

申请日：1987-12-01

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: A23L27/30 ,  C07K1/02 ,  C07K5/06 ,  C07K5/075

Abstract: alpha -L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying alpha -L-aspartyl-L-phenylalanine or alpha -L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected- alpha -L-aspartyl-L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting alpha -L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide.

公开(公告)号：DE3780585T2

公开(公告)日：1993-03-18

申请号：DE3780585

申请日：1987-12-01

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: A23L27/30 ,  C07K1/02 ,  C07K5/06 ,  C07K5/075

Abstract: alpha -L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying alpha -L-aspartyl-L-phenylalanine or alpha -L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected- alpha -L-aspartyl-L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting alpha -L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide.

公开(公告)号：DE3585219D1

公开(公告)日：1992-02-27

申请号：DE3585219

申请日：1985-12-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIGUCHI CHOJIRO ,  KATOH TOSHIO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: C07K1/02 ,  C07K5/06 ,  C07K5/075

Abstract: A process for preparing N-formyl- alpha -aspartyl phenylalanine by condensing N-formyl aspartic acid anhydride and phenylalanine which comprises effecting the condensation reaction in a water medium while maintaining the pH during the reaction in the range of 7-12 and preferably at a reaction temperature of 50 DEG C or below.

公开(公告)号：NO168944B

公开(公告)日：1992-01-13

申请号：NO861189

申请日：1986-03-25

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: C07K5/06 ,  C07K5/075

Abstract: The present invention relates to a process for preparing alpha -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride. alpha -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride is prepared by a process comprising: condensating N-formyl-L-aspartic acid anhydride and L-phenylalanine in water or in water containing methanol at a pH in the range of 7-12 to form N-formyl- alpha -L-aspartyl-L-phenylalanine; acidifying the reaction mixture successively with hydrochloric acid in the presence of methanol without isolating the N-formyl- alpha -L-aspartyl-L-phenylalanine so as to bring it into contact with hydrochloric acid in the presence of methanol for reaction and thereby to deposit alpha -L-aspartyl-L-phenylalanine methyl ester hydrochloride; separating the alpha -L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride as required.

公开(公告)号：BR9004944A

公开(公告)日：1991-09-10

申请号：BR9004944

申请日：1990-10-02

Applicant: MITSUI TOATSU CHEMICALS

Inventor： AKIEDA HIDEYUKI ,  SATO NAOKI ,  MORINAGA KOICHI ,  IDE YOSHINORI ,  MITA RYUICHI ,  UMEMOTO MITSUMASA

IPC: B01J23/04 ,  B01J31/02 ,  C07B61/00 ,  C07C41/26 ,  C07C43/295 ,  C07C43/16 ,  C07C43/17 ,  C07C43/178 ,  C07C41/28

Abstract: A process for producing a p-hydroxyneophyl m-phenoxybenzyl ether represented by the general formula (II) (X1 and X2 are independently a hydrogen atom or a halogen atom) by subjecting a corresponding p-alkoxyneophyl m-phenoxybenzyl ether represented by the general formula (I) (R represents a lower alkyl group, and X1 and X2 have the same definitions as above) to ether cleavage, in which process the ether cleavage reaction is effected in an aprotic polar solvent, using a lower alkoxide of an alkali metal or an alkaline earth metal or using a metal hdyroxide in the presence of a lower alcohol.

公开(公告)号：DE3674830D1

公开(公告)日：1990-11-15

申请号：DE3674830

申请日：1986-03-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: C07K5/06 ,  C07K5/075

Abstract: The present invention relates to a process for preparing alpha -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride. alpha -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride is prepared by a process comprising: condensating N-formyl-L-aspartic acid anhydride and L-phenylalanine in water or in water containing methanol at a pH in the range of 7-12 to form N-formyl- alpha -L-aspartyl-L-phenylalanine; acidifying the reaction mixture successively with hydrochloric acid in the presence of methanol without isolating the N-formyl- alpha -L-aspartyl-L-phenylalanine so as to bring it into contact with hydrochloric acid in the presence of methanol for reaction and thereby to deposit alpha -L-aspartyl-L-phenylalanine methyl ester hydrochloride; separating the alpha -L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride as required.