公开(公告)号：JPH0711287A

公开(公告)日：1995-01-13

申请号：JP15198893

申请日：1993-06-23

Applicant: MITSUI TOATSU CHEMICALS

Inventor： HONDA MASATO ,  WADA MASARU ,  KAMASHITA TOMOKO

IPC: A61K8/00 ,  A61K8/44 ,  A61Q5/02 ,  A61Q19/10 ,  C11D1/02 ,  C11D3/33 ,  A61K7/075 ,  A61K7/50

Abstract: PURPOSE:To obtain the subject composition capable of improving feeling of use to skin and combing property to hair, having soft forming power, feeling of use and low irritation by containing a N-acyl neutral amino acid magnesium salt and an anionic surfactant as essential components. CONSTITUTION:The objective composition consists essentially of (A) a N-acyl neutral amino acid magnesium salt and (B) an anionic surfactant and blend weight ratio of the component A to the component B is (1:99) to (50:50). Furthermore, the acyl group is 8-20C (un)saturated fatty acid residue and further, the amino acid is preferably N-methyl-beta-alanine or sarcosine.

公开(公告)号：JPH069508A

公开(公告)日：1994-01-18

申请号：JP16593592

申请日：1992-06-24

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MIZUTA HIDEKI ,  NISHIMURA TAKESHI ,  WADA MASARU ,  NAGATA TERUYUKI

IPC: B01J31/02 ,  C07B61/00 ,  C07C201/16 ,  C07C205/06 ,  C07C205/38

Abstract: PURPOSE:To selectively convert o- and p-isomers into the corresponding phenoxynitrobenzenes and separate the resultant phenoxynitrobenzens from the reaction mixture by reacting crude m-dinitrobenzene(DNB) containing o- and p-isomers with phenols. CONSTITUTION:Crude m-DNB containing o- and p-DNB is made to react with a compound of formula I and/or formula II (R is H, halogen, OH, alkyl, NH2, alkoxy, carboxyl, acetyl, phenyl or benzyl; m is 1-5; n is 1-4; X is 1-10C divalent hydrocarbon group, C(CF3)2, CO, S, SO, SO2, O, NH, N=N, etc.) in the presence of a basic compound, e.g. hydroxide of an alkali (earth) metal, a carbonic acid salt, etc., especially sodium hydroxide and as necessary, a phase transfer catalyst to substantially selectively convert only o- and p-DNB into corresponding phenoxynitrobenzenes. The resultant phenoxynitrobenzenes are separated from the resultant reaction mixture to provide the objective high-purity m-DNB.

公开(公告)号：JPH05310627A

公开(公告)日：1993-11-22

申请号：JP11706992

申请日：1992-05-11

Applicant: MITSUI TOATSU CHEMICALS ,  MITSUBISHI PAPER MILLS LTD

Inventor： NAGATA TERUYUKI ,  WADA MASARU ,  IIDA TOMOYUKI ,  OKUMURA FUMIO

IPC: B01J23/04 ,  C07B61/00 ,  C07C41/16 ,  C07C43/205 ,  C07C43/225 ,  C07C201/12 ,  C07C205/37 ,  C07C319/20 ,  C07C323/20

Abstract: PURPOSE:To obtain a bis(phenoxyalkoxy)xylene compound in a high yield and in a high quality by reacting a (substituted)phenoxyalcohol with xylylene dichloride in the presence of a base, while controlling the concentration of the base in an aqueous layer and dropping the xylylene dichloride. CONSTITUTION:A phenoxyalcohol (which may be substituted) of formula I (R1 is 1-10C divalent group which may contain an ether bond or sulfide bond; R2 is H, alkyl, halogen, nitro, CF3, methylthio; n is 0-5) [e.g. 2-(4- chlorophenoxy)ethanol] is reacted with a xylylene dichloride of formula II in the presence of a base to obtain a bis(phenoxyalkoxy)xylene. In the process, the concentration of the base in the aqueous layer is kept to 25-45wt.%, and the xylylene dichloride is dropped. The method is extremely profitable due to its reduced by-products and high yield. The produced compound is useful as an intermediate for industrial chemicals.

公开(公告)号：JPH0579039B2

公开(公告)日：1993-11-01

申请号：JP2025086

申请日：1986-02-03

Applicant: MITSUI TOATSU CHEMICALS

Inventor： YAMAGUCHI TERUHIRO ,  YAMAGUCHI KEISABURO ,  TANABE YOSHIMITSU ,  ASANO MAKOTO ,  WADA MASARU

IPC: B41M5/155 ,  C08G61/10

公开(公告)号：JPH05112513A

公开(公告)日：1993-05-07

申请号：JP27243591

申请日：1991-10-21

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KAMASHITA TOMOKO ,  WADA MASARU ,  NAGATA TERUYUKI

IPC: C07C227/26 ,  C07B61/00 ,  C07C229/12

Abstract: PURPOSE:To enable the nearly quantitative production of the subject compound used as an intermediate for industrial chemicals by dropping beta- methylaminopropionitrile in an aqueous solution containing additives such as NaOH at a temperature lower than a specific one. CONSTITUTION:On the hydrolysis of beta-methylaminopropionitrile, the reaction temperature is set lower than 80 deg.C, preferably to from 50 deg.C to 70 deg.C, and beta- methylaminopropionitrile is added dropwise to an aqueous solution containing additives which may be either an alkali or an acid, for example, diluted sulfuric acid to effect the hydrolysis into N-methyl-beta-alanine. The hydrolysis preferably takes over 2 hours. beta-alanine is useful as an intermediate of especially N-long chain acylamino acid type surfactant. This process can achieve high yield and high product quality.

公开(公告)号：JPH0477457A

公开(公告)日：1992-03-11

申请号：JP19072590

申请日：1990-07-20

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KASE MOTOHIRO ,  WADA MASARU ,  NAGATA TERUYUKI ,  YAMAGUCHI TERUHIRO

IPC: C07C201/08 ,  C07C205/06

Abstract: PURPOSE:To industrially advantageously obtain the subject compound in high yield with suppressing side reaction without requiring an excessive cooling equipment by performing a nitration reaction by simultaneously adding an indane derivative and a mixed acid into a reactor previously charged with a reaction solvent. CONSTITUTION:A reaction solvent such as 1,2-dichloroethane inert to well-known nitration agents is previously charged to a reactor and a nitration reaction is performed by simultaneously adding an indane derivative expressed by formula I (R1 and R2 are H or 1-4C lower alkyl) obtained by a reaction of a benzene derivative and isoprene in the presence of an acid catalyst and a mixed acid of sulfuric acid and nitric acid containing >=74% sulfuric acid preferably keeping at -20 deg.C to 0 deg.C to afford the objective compound expressed by formula II, useful as a raw material for producing a diaminoindane derivative as a raw material of isocyanate, epoxy resin and bismaleimide, etc., or as a hardener of polyurethane. 2-2.2 times mol of said nitric acid is used to 1mol of the compound expressed by formula I.

公开(公告)号：JPH0276849A

公开(公告)日：1990-03-16

申请号：JP15470689

申请日：1989-06-19

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MATSUKAWA MIHAYA ,  WADA MASARU ,  MINAZU HIROSHI ,  FURUYA MASAYUKI ,  NAGATA TERUYUKI

IPC: C07D207/10 ,  C07D207/40 ,  C07D207/416

Abstract: PURPOSE:To quantitatively and advantageously obtain the subject compound which is a raw material for resins, medicines, agricultural chemicals or material for optical elements without troublesome operation by using phosgene readily available at a low cost with maleamic acid in the presence of a catalyst. CONSTITUTION:Phosgene is reacted with maleamic acid expressed by formula I [n is 1 or 2; Q is unsubstituted or substituted aryl, alkyl or cycloalkyl when n is 1 and unsubstituted or substituted phenylene, naphthylene or bifunctional organic group expressed by formula II or III (X is -O-, -S-, -S-S-, -SO2-, etc.) when n is 2] in the presence of a catalyst in an organic solvent, such as benzene, preferably at 20-80 deg.C to afford a compound expressed by formula IV. The phosgene is used at 1 molar ratio when n in the compound expressed by formula I is 1 and a slight excess over 2 molar ratio when n is 2. Furthermore, imidazole, dimethylformamide, etc., are preferred as the catalyst.

公开(公告)号：JPS6313976B2

公开(公告)日：1988-03-29

申请号：JP586280

申请日：1980-01-23

Applicant: MITSUI TOATSU CHEMICALS

Inventor： NAGATA TERUYUKI ,  TAMAOKI AKIHIRO ,  WADA MASARU

IPC: C07C53/38 ,  B01J31/00 ,  B01J31/02 ,  C07B61/00 ,  C07C51/00 ,  C07C51/60 ,  C07C51/64 ,  C07C57/72 ,  C07C63/30 ,  C07C67/00

公开(公告)号：JPS62292761A

公开(公告)日：1987-12-19

申请号：JP13488886

申请日：1986-06-12

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KAJIMOTO NOBUYUKI ,  NAGATA TERUYUKI ,  WADA MASARU

IPC: C07D233/34

Abstract: PURPOSE:To obtain 2-imidazolidinones useful as a solvent for various characteris tic organic reactions in high yield and industrially advantageously, by reacting a diamine with urea at >= a fixed temperature in a polar solvent. CONSTITUTION:A diamine (e.g. N,N'-dimethyl-1,2-propanediamine, etc.) shown by formula I (R is lower alkyl; R -R are H or alkyl and at least one of them is alkyl) is reacted with urea in the presence of a polar solvent (especially preferably 2-imidazolidinone shown by formula II, reaction product of the reaction) at >=180 deg.C to give a 2-imidazolidinone (e.g. 1,3,4-trimethyl-2-imidazolidinone, etc.) shown by formula II. In the reaction, the diamine/urea are fed in a molar ratio of diamine/urea of approximately 1/2, the reaction is especially carried out at >=140 deg.C until formation of urea intermediate is completed and then the reaction is done at >=180 deg.C while adding the diamine.

公开(公告)号：JPS62265269A

公开(公告)日：1987-11-18

申请号：JP10777186

申请日：1986-05-13

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KAJIMOTO NOBUYUKI ,  NAGATA TERUYUKI ,  WADA MASARU

IPC: C07D233/34

Abstract: PURPOSE:To obtain the titled compound useful as an aprotic polar solvent or an intermediate for pharmaceuticals and agricultural chemicals, in improved yield at a low cost with decreased consumption of phosgene, by reacting a diamine with phosgene in the presence of water and a dehydrochlorination agent. CONSTITUTION:The compound of formula II can be produced by reacting 1mol of a diamine of formula I (R is lower alkyl; R , R , R and R are H or lower alkyl; at least one of R -R is lower alkyl) with preferably 1.0-1.5mol of phosgene essentially in the presence of water and a dehydrochlorination agent preferably at 0-70 deg.C. The pH of the reaction system is maintained at 3.0-10.0, preferably 5.0-8.0 during the reaction. The amount of water is 0.5-50pts.wt., preferably 3-30pts.wt. per 1t.wt. of the diamine. The dehydrochlorination agent is e.g. sodium hydroxide, etc., at an amount of 1.0-1.5mol per 1mol of the diamine.