公开(公告)号：NO20013958A

公开(公告)日：2001-10-15

申请号：NO20013958

申请日：2001-08-15

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61D9/12

CPC classification number: A61K31/55

公开(公告)号：DE19932555A1

公开(公告)日：2001-01-18

申请号：DE19932555

申请日：1999-07-13

Applicant: SOLVAY PHARM GMBH

Inventor： ROZA ZSUZSANNA ,  PAPP JULIUS GY ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61K31/704 ,  A61K45/00 ,  A61K45/06 ,  A61P9/00 ,  A61P21/00 ,  A61P35/00 ,  A61P37/04 ,  A61P39/02 ,  A61P39/06

Abstract: The invention relates to the utilization of benzazepine-N-acetic acid derivatives which contain an oxogroup in addition to the nitrogen atom in the alpha position and which are substituted in the third position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical and to their salts and biolabile esters for the prophylaxis and/or treatment of heart damages caused by cardiotoxic doses of medicaments or chemicals in large mammals and particularly human beings. The invention particularly relates to the prophylaxis and/or treatment of heart damages, especially myocardial damages, which may occur during cytostatic chemotherapy. The invention further relates to the utilization of the above-mentioned benzazepine-N-acetic acid derivatives for adjuvant treatment in therapies in which medicaments with oxidative-toxic side effects are used. The invention additionally relates to the production of medicaments suitable for said prophylaxis and/or treatment or adjuvant treatment.

公开(公告)号：DE59606160D1

公开(公告)日：2001-01-04

申请号：DE59606160

申请日：1996-03-18

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAEHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：DE19906310A1

公开(公告)日：2000-08-17

申请号：DE19906310

申请日：1999-02-16

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: 3-(1-(2-Aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tet rahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives (I) are used to prepare pharmaceutical compositions for treating hypertension in large mammals and humans. 3-(1-(2-Aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tet rahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives of formula (I) or their salts are used to prepare pharmaceutical compositions for treating hypertension in large mammals and humans. R = phenyl- or naphthyl-substituted lower alkyl, where phenyl is optionally substituted by lower alkyl, lower alkoxy or halogen; R , R = H or biolabile ester groups.

公开(公告)号：BR9804582A

公开(公告)日：2000-05-09

申请号：BR9804582

申请日：1998-11-11

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  MEIL JOERG ,  THORMAEHLEN DIRK ,  WURL MICHAEL

IPC: A61K31/675 ,  A61K31/00 ,  A61K31/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D223/16 ,  C07F9/38 ,  C07F9/40 ,  C07F9/553 ,  C07K5/06

Abstract: 3-(1-Phosphonomethyl-cyclopentane-1-carbonylamino)-2,3,4,5-tetrahydro- 2-oxo-1H-1-benzazepine-1-acetic acid derivatives (I) are new. Benzazepine derivatives of formula (I) and their salts are new: R1-R3 = H or biolabile ester residue. An Independent claim relates to the preparation of (I).

公开(公告)号：PL329635A1

公开(公告)日：1999-05-24

申请号：PL32963598

申请日：1998-11-10

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  MEIL JOERG ,  THORMAEHLEN DIRK ,  WURL MICHAEL

IPC: A61K31/675 ,  A61K31/00 ,  A61K31/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  C07D223/16 ,  C07F9/38 ,  C07F9/40 ,  C07F9/553 ,  C07K5/06 ,  A61K33/42

Abstract: 3-(1-Phosphonomethyl-cyclopentane-1-carbonylamino)-2,3,4,5-tetrahydro- 2-oxo-1H-1-benzazepine-1-acetic acid derivatives (I) are new. Benzazepine derivatives of formula (I) and their salts are new: R1-R3 = H or biolabile ester residue. An Independent claim relates to the preparation of (I).