公开(公告)号：HK1125113A1

公开(公告)日：2009-07-31

申请号：HK09102389

申请日：2009-03-12

Applicant: UCB PHARMA SA

Inventor： GELINAS RICHARD EVAN ,  SINGHAL MITRA CHOUDHURY ,  ZHANG YI ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C07K20060101

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：AU2002334135B2

公开(公告)日：2009-01-08

申请号：AU2002334135

申请日：2002-10-10

Applicant: UCB PHARMA SA

Inventor： ZINKEWICH-PEOTTI KAREN ,  POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  MORRISON ROBERT KENDALL

IPC: C12N15/09 ,  A61K39/395 ,  A61K47/48 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

Abstract: There are disclosed antibody molecules containing at least on CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.

公开(公告)号：AU2008232409A1

公开(公告)日：2008-10-02

申请号：AU2008232409

申请日：2008-03-21

Applicant: BIOGEN IDEC INC ,  UCB PHARMA SA

Inventor： GARBER ELLEN A ,  ROBINSON MARTYN KIM ,  SHOCK ANTHONY ,  TAYLOR FREDERICK R ,  BURKLY LINDA C ,  HSU YEN-MING ,  FERRANT-ORGETTAS JANINE L ,  BROWN DEREK THOMAS ,  POPPLEWELL ANDREW GEORGE ,  SU LIHE ,  ADAMS RALPH ,  TYSON KERRY LOUISE

IPC: C07K16/28 ,  A61K39/395 ,  C12N15/13 ,  C12N15/63

Abstract: This invention provides binding proteins, including antibodies, antibody derivates and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivate or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

公开(公告)号：NO20083066A

公开(公告)日：2008-09-08

申请号：NO20083066

申请日：2008-07-08

Applicant: UCB PHARMA SA

Inventor： GELINAS RICHARD EVAN ,  SINGHAL MITRA CHOUDHURY ,  ZHANG YI ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C07K16/24 ,  A61K39/395 ,  C07K16/18

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  C07K16/248 ,  C07K2316/96 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

公开(公告)号：ECSP088613A

公开(公告)日：2008-08-29

申请号：ECSP088613

申请日：2008-07-07

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  GELINAS RICHARD EVAN ,  SINGHAL MITRA CHOUDHURY ,  ZHANG YI ,  ADAMS RALPH

Abstract: La invención se relaciona con las moléculas de anticuerpo que tienen especificidad para determinantes antigénicos de la IL-6, los usos terapéuticos de las moléculas de anticuerpo y los métodos para producir dichas moléculas de anticuerpo.

公开(公告)号：AU2007311689A1

公开(公告)日：2008-04-24

申请号：AU2007311689

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE

IPC: A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C07K16/24 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：PE20080214A1

公开(公告)日：2008-04-08

申请号：PE2007000825

申请日：2007-06-26

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C12N5/20 ,  C12N15/13

Abstract: SE REFIERE A UN ANTICUERPO QUE INHIBE LA ACTIVIDAD DE LA INTERLEUQUINA 17 (IL-17) QUE COMPRENDE: A) UNA CADENA PESADA CUYO DOMINIO VARIABLE SE ENCUENTRA EN LA SEC ID Nº: 1 PARA CDR-H1, SEC ID Nº: 2 PARA CDR-H2 Y SEC ID Nº: 3 PARA CDR-H3; B) UNA CADENA LIGERA CUYO DOMINIO VARIABLE SE ENCUENTRA EN LA SEC ID Nº: 4 PARA CDR-L1, SEC ID Nº: 5 PARA CDR-L2 Y SEC ID Nº: 6 PARA CDR-L3. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION DEL ANTICUERPO. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN, PSORIASIS

公开(公告)号：SK288706B6

公开(公告)日：2019-10-02

申请号：SK500812015

申请日：2001-06-05

Applicant: UCB PHARMA SA

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/68 ,  A61P19/02 ,  A61P37/06 ,  C07K16/46 ,  C07K19/00 ,  C12N1/21 ,  C12N15/13 ,  C12N15/62 ,  C12N15/70

Abstract: Vynález sa týka protilátkových molekúl, ktoré sú špecifické pre antigénne determinanty nádorového nekrotického faktora alfa (TNFα). Na C-konci ťažkého reťazca týchto molekúl je pripojená efektorová alebo reportérová molekula, výhodne metoxypoly(etylénglykol). Vynález sa ďalej týka terapeutického použitia protilátkových molekúl na liečenie chorôb sprostredkovaných TNFα.

公开(公告)号：AU2003223007C1

公开(公告)日：2019-08-08

申请号：AU2003223007

申请日：2003-05-02

Applicant: UCB PHARMA SA

Inventor： LADYMAN HEATHER MARGARET ,  TICKLE SIMON PETER ,  POPPLEWELL ANDREW GEORGE

IPC: C07K16/18 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

公开(公告)号：DK3059314T3

公开(公告)日：2019-02-18

申请号：DK16154916

申请日：2001-06-05

Applicant: UCB PHARMA SA

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/09 ,  C12N15/13 ,  A61K39/395 ,  A61K47/48 ,  A61K47/68 ,  A61P19/02 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C07K16/46 ,  C12N1/21 ,  C12P21/02 ,  C12P21/08