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公开(公告)号：AU2025200232A1
公开(公告)日：2025-02-13
申请号：AU2025200232
申请日：2025-01-13
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: C07D487/04 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/662 , A61P35/00 , C07D487/00 , C07D487/02
Abstract: Abstract Disclosed are heterocyclic compounds as inhibitors of General amino acid control Non-depressible-2 (GCN2) and their use in the treatment of diseases such as cancers.
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公开(公告)号：AU2019212969B2
公开(公告)日：2025-01-23
申请号：AU2019212969
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DONG HUIJUN , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KNEGTEL RONALD , MOCHALKIN IGOR , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , QIU HUI , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: A61K31/395 , A61K31/437 , A61K31/4375 , C07D231/02 , C07D471/04 , C07D487/04
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. Compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of GCN2 kinase.
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公开(公告)号：HUE055618T2
公开(公告)日：2021-12-28
申请号：HUE18212042
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , BOYALL DEAN , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DAVIS REBECCA , DURRANT STEVEN , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVID , KNEGTEL RONALD , MIDDELTON DONALD , ODONNELL MICHAEL , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , SHAW DAVID , STORCK PIERRE-HENRI , STUDLEY JOHN , TWIN HEATHER
IPC: C07D487/04 , A61P35/00 , C07D453/02 , C07D471/08 , C07D498/04 , C07D498/10
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64.发明专利
公开(公告)号：SI3486245T1
公开(公告)日：2021-09-30
申请号：SI201331909
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , BOYALL DEAN , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DAVIS REBECCA , DURRANT STEVEN , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVID , KNEGTEL RONALD , MIDDELTON DONALD , ODONNELL MICHAEL , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , SHAW DAVID , STORCK PIERRE-HENRI , STUDLEY JOHN , TWIN HEATHER
IPC: C07D487/00 , A61K31/00 , A61P35/00 , C07D453/00 , C07D471/00 , C07D491/00 , C07D498/00
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65.发明专利
公开(公告)号：DK3486245T3
公开(公告)日：2021-07-19
申请号：DK18212042
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： DURRANT STEVEN , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVID , KNEGTEL RONALD , MIDDELTON DONALD , ODONNELL MICHAEL , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , SHAW DAVID , STORCK PIERRE-HENRI , STUDLEY JOHN , TWIN HEATHER , AHMAD NADIA , BOYALL DEAN , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DAVIS REBECCA
IPC: C07D487/04 , A61K31/495 , A61P35/00 , C07D453/02 , C07D471/08 , C07D491/107 , C07D498/04 , C07D498/10
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Patent Agency Ranking66.发明专利
公开(公告)号：LT3418281T
公开(公告)日：2021-01-11
申请号：LT18159811
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , BOYALL DEAN , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DAVIS REBECCA , DURRANT STEVEN , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMINE , JIMENEZ JUAN-MIGUEL , KAY DAVID , KNEGTEL RONALD , MIDDLETON DONALD , ODONNELL MICHAEL , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , SHAW DAVID , STORCK PIERRE-HENRI , STUDLEY JOHN , TWIN HEATHER
IPC: C07D487/04 , A61K31/495 , A61P35/00 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
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公开(公告)号：AU2019211485A1
公开(公告)日：2020-08-06
申请号：AU2019211485
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: A61K31/495 , A61K31/505 , A61K31/519 , C07D487/00 , C07D487/02 , C07D487/04
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号：ES2777608T3
公开(公告)日：2020-08-05
申请号：ES15745265
申请日：2015-05-28
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , KNEGTEL RONALD , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , STORCK PIERRE-HENRI , STUDLEY JOHN
IPC: C07D487/04
Abstract: Un compuesto de Fórmula l-A: **(Ver fórmula)** o una de sus sales farmacéuticamente aceptables, en la que: cada Y1, Y2, Y3, Y4, Y5, Y6 e Y7 es independientemente hidrógeno o deuterio; con la condición de que al menos uno de Y1, Y2, Y3, Y4, Y5, Y6 e Y7 es deuterio; cada X1, X2 y X4 es independientemente 12C o 13C; y X3 es independientemente -12C(O)- o -13C(O)-.
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公开(公告)号：RS60013B1
公开(公告)日：2020-04-30
申请号：RSP20200256
申请日：2015-05-28
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , KNEGTEL RONALD , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , STORCK PIERRE-HENRI , STUDLEY JOHN
IPC: C07D487/04
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公开(公告)号：CA3089769A1
公开(公告)日：2019-08-01
申请号：CA3089769
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DONG HUIJUN , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KNEGTEL RONALD , MOCHALKIN IGOR , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , QIU HUI , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: C07D471/04 , A61K31/395 , A61K31/444 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/551 , C07D519/00
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. Compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of GCN2 kinase.
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