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公开(公告)号：WO2014143242A8
公开(公告)日：2015-03-05
申请号：PCT/US2013073477
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DURRANT STEVEN , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVE , KNEGTEL RONALD , O'DONNELL MICHAEL , PIERARD FRANCOISE , PINDER JOANNE , STORCK PIERRE-HENRI , TWIN HEATHER
IPC: C07D487/04 , A61K31/437 , A61P35/00
CPC classification number: C07D487/04 , A61K31/437 , C07D491/107 , C07D519/00
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I); or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明化合物具有式（I）; 或其药学上可接受的盐，其中变量R1，R2，R3和R4如本文所定义。
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公开(公告)号：WO2008094992A3
公开(公告)日：2008-12-04
申请号：PCT/US2008052443
申请日：2008-01-30
Applicant: VERTEX PHARMA , JIMENEZ JUAN-MIGUEL , BEMIS GUY , MALTAIS FRANCOIS , WANG TIANSHENG , KNEGTEL RONALD , DAVIS CHRIS , FRAYSSE DAMIEN , BOYALL DEAN , SETTIMO LUCA , YOUNG STEPHEN , MORTIMORE MICHAEL
Inventor： JIMENEZ JUAN-MIGUEL , BEMIS GUY , MALTAIS FRANCOIS , WANG TIANSHENG , KNEGTEL RONALD , DAVIS CHRIS , FRAYSSE DAMIEN , BOYALL DEAN , SETTIMO LUCA , YOUNG STEPHEN , MORTIMORE MICHAEL
IPC: C07D213/73 , A61K31/444 , A61K31/529 , A61P25/00 , A61P35/00 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
CPC classification number: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The present invention relates to compounds represented by the following structural formula: (I) useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of µsing the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及由以下结构式表示的化合物：（I）可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2007056164A3
公开(公告)日：2007-12-13
申请号：PCT/US2006042994
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物以及使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：WO2007056221A2
公开(公告)日：2007-05-18
申请号：PCT/US2006043096
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
IPC: A61K31/513
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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5.发明申请RADIOLABELLED DERIVATIVES OF A 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]- PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, THE PREPARATION OF SAID COMPOUND AND DIFFERENT SOLID FORMS THEREOF 审中-公开用于ATR激酶抑制剂的2-氨基-6-氟-N- [5-氟-2-吡啶-3-基] - 吡唑并[1,5-A]嘧啶-3-羰氧基化合物的放射性衍生物，制备化合物 化合物和不同的固体形式
公开(公告)号：WO2015187451A9
公开(公告)日：2016-05-19
申请号：PCT/US2015032879
申请日：2015-05-28
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , KNEGTEL RONALD , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , STORCK PIERRE-HENRI , STUDLEY JOHN
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula (I-l) or (I-A); wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 和本发明化合物的固体形式。 本发明化合物具有式（I-1）或（I-A）; 其中变量如本文所定义。
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Patent Agency Ranking
公开(公告)号：WO2014089379A1
公开(公告)日：2014-06-12
申请号：PCT/US2013073457
申请日：2013-12-06
Applicant: VERTEX PHARMA
Inventor： AHMAD NADIA , BOYALL DEAN , CHARRIER JEAN-DAMIEN , DAVIS CHRIS , DAVIS REBECCA , DURRANT STEVEN , ETXEBARRIA I JARDI GORKA , FRAYSSE DAMIEN , JIMENEZ JUAN-MIGUEL , KAY DAVID , KNEGTEL RONALD , MIDDLETON DONALD , ODONNELL MICHAEL , PANESAR MANINDER , PIERARD FRANCOISE , PINDER JOANNE , SHAW DAVID , STORCK PIERRE-HENRI , STUDLEY JOHN , TWIN HEATHER
IPC: C07D487/04 , A61K31/495 , A61P35/00
CPC classification number: C07D487/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula (I-A) or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式（I）或其药学上可接受的盐，其中变量如本文所述。 此外，本发明的化合物具有式（I-A）或其药学上可接受的盐，其中变量如本文所定义。
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公开(公告)号：WO2007056163A3
公开(公告)日：2008-03-27
申请号：PCT/US2006042993
申请日：2006-11-03
Applicant: VERTEX PHARMA , BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , RUTHERFORD ALISTAIR
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , RUTHERFORD ALISTAIR
IPC: C07D403/14 , A61K31/4155 , C07D239/02
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases . The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders . The invention also provides processes for preparing compounds of the invention.
Abstract translation: 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：EP1951715A4
公开(公告)日：2011-11-09
申请号：EP06827465
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , RUTHERFORD ALISTAIR
IPC: C07D401/14 , A61K31/505 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP1954277A4
公开(公告)日：2011-11-09
申请号：EP06836938
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , DAVIS CHRIS , BOYALL DEAN , EVERITT SIMON , ROBINSON DANIEL , RAMAYA SHARN , FRAYSSE DAMIEN , STUDLEY JOHN , MILIER ANDREW , O'DONNELL MICHAEL , RUTHERFORD ALISTAIR , PINDER JOANNE
IPC: A61K31/505 , C07D239/02 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP1948193A4
公开(公告)日：2011-11-09
申请号：EP06836890
申请日：2006-11-03
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , MORTIMORE MICHAEL , FRAYSSE DAMIEN , DAVIS CHRIS , O'DONNELL MICHAEL , EVERITT SIMON , ROBINSON DANIEL , PINDER JOANNE , MILLER ANDREW
IPC: C07D401/14 , A61K31/505 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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