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    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    1.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
    化合物作为ATR激酶的抑制剂有用

    公开(公告)号：WO2014143242A8

    公开(公告)日：2015-03-05

    申请号：PCT/US2013073477

    申请日：2013-12-06

    Applicant: VERTEX PHARMA

    Inventor： CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  DURRANT STEVEN ,  FRAYSSE DAMIEN ,  JIMENEZ JUAN-MIGUEL ,  KAY DAVE ,  KNEGTEL RONALD ,  O'DONNELL MICHAEL ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STORCK PIERRE-HENRI ,  TWIN HEATHER

    IPC: C07D487/04 ,  A61K31/437 ,  A61P35/00

    CPC classification number: C07D487/04 ,  A61K31/437 ,  C07D491/107 ,  C07D519/00

    Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I); or a pharmaceutically acceptable salt, wherein the variables R1, R2, R3, and R4 are as defined herein.

    Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明化合物具有式（I）; 或其药学上可接受的盐，其中变量R1，R2，R3和R4如本文所定义。

    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    6.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
    化合物作为ATR激酶的抑制剂有用

    公开(公告)号：WO2014089379A1

    公开(公告)日：2014-06-12

    申请号：PCT/US2013073457

    申请日：2013-12-06

    Applicant: VERTEX PHARMA

    Inventor： AHMAD NADIA ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRIS ,  DAVIS REBECCA ,  DURRANT STEVEN ,  ETXEBARRIA I JARDI GORKA ,  FRAYSSE DAMIEN ,  JIMENEZ JUAN-MIGUEL ,  KAY DAVID ,  KNEGTEL RONALD ,  MIDDLETON DONALD ,  ODONNELL MICHAEL ,  PANESAR MANINDER ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  SHAW DAVID ,  STORCK PIERRE-HENRI ,  STUDLEY JOHN ,  TWIN HEATHER

    IPC: C07D487/04 ,  A61K31/495 ,  A61P35/00

    CPC classification number: C07D487/04 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

    Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula (I-A) or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

    Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式（I）或其药学上可接受的盐，其中变量如本文所述。 此外，本发明的化合物具有式（I-A）或其药学上可接受的盐，其中变量如本文所定义。

    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    7.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
    化合物作为ATR激酶的抑制剂有用

    公开(公告)号：WO2011143423A3

    公开(公告)日：2012-03-01

    申请号：PCT/US2011036243

    申请日：2011-05-12

    Applicant: VERTEX PHARMA ,  CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  VIRANI ANIZA NIZARALI ,  REAPER PHILIP MICHAEL ,  PINDER JOANNE

    Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  VIRANI ANIZA NIZARALI ,  REAPER PHILIP MICHAEL ,  PINDER JOANNE

    IPC: C07D239/46 ,  A61K31/422 ,  A61P35/00 ,  C07D413/04

    CPC classification number: C07D241/20 ,  C07D401/04 ,  C07D403/04

    Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (V): (Formula (v)) wherein the variables are as defined herein.

    Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的吡嗪和吡啶化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式（V）：（式（v）），其中变量如本文所定义。

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