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公开(公告)号：KR1020050014993A
公开(公告)日：2005-02-21
申请号：KR1020030053437
申请日：2003-08-01
Applicant: 대한민국 (식품의약품안전처장)
IPC: A01K67/027
CPC classification number: A01K67/0276 , A01K2227/105 , C12N15/63
Abstract: PURPOSE: A double-transgenic dementia mouse expressing a mutant PS2 gene and an APPsw gene is provided to show perfectly dementia symptoms and to be useful in developing a dementia treatment and improving an early diagnostic test of the disease. CONSTITUTION: The double-transgenic dementia mouse is produced by mating a single-transgenic mouse(A) with a single-transgenic mouse(B). The transgenic mouse(A) expressing a mutant PS2 gene is produced by following steps of: preparing a recombinant fusion gene by connecting an mutant PS2 gene to a promoter of a Neuron-Specific Enolase gene; microinjecting the recombinant fusion gene into a fertilized egg of a mouse; and breeding the transgenic mice(A) by nidating the fertilized egg into a surrogate mother mouse. The transgenic mouse(B) expressing an APPsw gene is produced in the same manner.
Abstract translation: 目的：提供表达突变型PS2基因和APPsw基因的双转基因痴呆小鼠以显示完全痴呆症状，并可用于开发痴呆症治疗并改善疾病的早期诊断测试。 构成：双转基因痴呆小鼠通过将单转基因小鼠（A）与单转基因小鼠（B）交配而产生。 通过以下步骤产生表达突变型PS2基因的转基因小鼠（A）：通过将突变PS2基因连接到神经元特异性烯醇化酶基因的启动子来制备重组融合基因; 将重组融合基因显微注射入小鼠的受精卵中; 并通过将受精卵覆盖到替代母亲小鼠中来培育转基因小鼠（A）。 以相同的方式制备表达APPsw基因的转基因小鼠（B）。
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公开(公告)号：KR100463075B1
公开(公告)日：2004-12-23
申请号：KR1020010055107
申请日：2001-09-07
Applicant: 한국화학연구원 , 대한민국 (식품의약품안전처장)
IPC: G01K3/04
Abstract: PURPOSE: A label for sensing temperature and time for cold distribution management is provided to promptly and accurately sense that products are exposed at a higher temperature than a regular temperature. CONSTITUTION: A heat sensitive hydrogel(1) is manufactured by using an acryl monomer contracting and expanding in volume by discharging and absorbing an aqueous solution according to the temperature to measure the temperature of exposure of a product to be kept at a cold temperature. A transfer paper(2) contains dye for measuring elapsed time according to the temperature of exposure. A capillary tube path(3) connects the heat sensitive hydrogel with the transfer paper, so that the hydrogel moves to the transfer paper through the capillary tube path if the hydrogel is leaked at a lower critical solution temperature.
Abstract translation: 目的：提供用于感测冷分布管理的温度和时间的标签，以及时并准确地感测产品暴露在比常温更高的温度下。 构成：热敏水凝胶（1）通过使用丙烯酸类单体通过根据温度排出和吸收水溶液而收缩并膨胀来制造，以测量待保持在低温下的产品的暴露温度。 转印纸（2）含有用于根据曝光温度测量经过时间的染料。 毛细管路径（3）将热敏水凝胶与转印纸连接，使得如果水凝胶在较低临界溶解温度下泄漏，则水凝胶通过毛细管路径移动到转印纸。
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公开(公告)号：KR100387279B1
公开(公告)日：2003-06-12
申请号：KR1020000079495
申请日：2000-12-21
Applicant: 대한민국 (식품의약품안전처장) , 대한민국(관리부서 : 산림청 국립산림과학원장)
IPC: A61K36/896
Abstract: PURPOSE: A pharmaceutical composition containing an Allium victorialis var. platyphyllum extract having a therapeutic and preventing activity against arteriosclerosis as an effective component is provided which can be effectively used as a pharmaceutical component and an effective component of functional food for prevention and treatment of arteriosclerosis and hypercholesterolemia. CONSTITUTION: A dried Allium victorialis var. platyphyllum is ground to 20 to 100 mesh, mixed 2 to 5 times with ethanol and extracted at 15 to 50deg.C for 24 to 96 hr. The extract remarkably reduces the amount of cholesterol and lipid peroxide in blood and has an inhibition activity on cholesteryl ester transfer protein enzyme for transferring HDL cholesterol to arteriosclerosis-inducing low density lipoprotein cholesterol.
Abstract translation: 目的：一种含有葱属植物变种的药物组合物。 提供具有针对动脉硬化的治疗和预防活性的扁桃酚提取物作为有效成分，其可以有效地用作用于预防和治疗动脉硬化和高胆固醇血症的功能性食品的药物成分和有效成分。 组成：干韭菜var。 将Platyphyllum粉碎至20至100目，用乙醇混合2至5次，并在15至50℃提取24至96小时。 该提取物显着降低血液中胆固醇和脂质过氧化物的量，并且对胆固醇酯转移蛋白酶具有抑制活性，用于将HDL胆固醇转化为诱导动脉硬化的低密度脂蛋白胆固醇。
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公开(公告)号：KR100382171B1
公开(公告)日：2003-04-26
申请号：KR1020000007092
申请日：2000-02-15
Applicant: 대한민국 (식품의약품안전처장)
Abstract: PURPOSE: A natural antioxidant containing an Origanum majorana extract as an effective component and process for purifying the same are provided, which can be used as a food additive for the prevention or inhibition of oxidative damage of protein, nucleic acid and enzyme in vivo. CONSTITUTION: The antioxidant having superoxide radical scavenging activity contains an Origanum majorana extract as an effective component, wherein the extract is obtained by extracting Origanum majorana with methanol or methanol and/or chloroform and ethyl acetate successively and purifying with an absorption chromatography.
Abstract translation: 目的：提供一种含有牛至草提取物作为有效成分的天然抗氧化剂及其提纯方法，其可用作预防或抑制体内蛋白质，核酸和酶的氧化损伤的食品添加剂。 一种具有超氧化物自由基清除活性的抗氧化剂，含有一种牛至草提取物作为有效成分，其中该提取物依次用甲醇或甲醇和/或氯仿和乙酸乙酯提取牛至，并用吸收色谱法提纯。
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公开(公告)号：KR1020010081483A
公开(公告)日：2001-08-29
申请号：KR1020000007092
申请日：2000-02-15
Applicant: 대한민국 (식품의약품안전처장)
Abstract: PURPOSE: A natural antioxidant containing an Origanum majorana extract as an effective component and process for purifying the same are provided, which can be used as a food additive for the prevention or inhibition of oxidative damage of protein, nucleic acid and enzyme in vivo. CONSTITUTION: The antioxidant having superoxide radical scavenging activity contains an Origanum majorana extract as an effective component, wherein the extract is obtained by extracting Origanum majorana with methanol or methanol and/or chloroform and ethyl acetate successively and purifying with an absorption chromatography.
Abstract translation: 目的：提供一种天然抗氧化剂，其含有牛至甘草提取物作为有效成分及其纯化方法，其可用作预防或抑制体内蛋白质，核酸和酶的氧化损伤的食品添加剂。 构成：具有超氧自由基清除活性的抗氧化剂含有作为有效成分的羊鞭草提取物，其中提取物通过依次用甲醇或甲醇和/或氯仿和乙酸乙酯萃取牛至来获得，并用吸收色谱纯化。
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Patent Agency Ranking
公开(公告)号：KR1020000024542A
公开(公告)日：2000-05-06
申请号：KR1020000007988
申请日：2000-02-19
Applicant: 대한민국 (식품의약품안전처장)
Abstract: PURPOSE: Extract from STAPF showing excellent effect in the HBV medicine field is provided, which has lower toxicity than any other existing compounds, so the extract from STAPF can be used as a safe and effective medicine for hepatitis B. CONSTITUTION: Extract from STAPF is gained from stems of STAPF. The extracting process comprises of: drying the stems thoroughly at place being well ventilated, or sunning the stems after drying till 60% dried state at place being well ventilated; adding 1L of water per 100g of dried STAPF; heating and gyrating for 2-3hrs at 100°C; extracting only 1 time. Dried powder type of the extract after freeze-drying, and water-soluble part of the extract by centrifuging after dissolving the dried powder are also used as an effective ingredient in the medicine for hepatitis B.
Abstract translation: 目的：提供在HBV药物领域表现出优异疗效的STAPF提取物，其毒性低于其他现有化合物，因此STAPF提取物可用作乙型肝炎安全有效的药物。构成：STAPF提取物为 从STAPF的茎获得。 提取方法包括：在通风良好的地方彻底干燥茎，或干燥后将茎干晒干至60％干燥状态，通风良好; 每100g干STAPF加入1L水; 在100°C加热旋转2-3小时; 仅提取1次。 冷冻干燥后的干粉提取物，溶解干燥粉末后通过离心分离提取物的水溶性部分也用作乙型肝炎药物中的有效成分。
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公开(公告)号：KR102255610B1
公开(公告)日：2021-05-26
申请号：KR1020210019894
申请日：2021-02-15
Applicant: 대한민국 (식품의약품안전처장) , (주)더모아젠
IPC: C12Q1/6888
Abstract: 본발명은왕지네의기원종감별용유전자마커에관한것으로, 본발명의유전자마커를이용함으로써, 한약재로사용되는왕지네의기원종을 PCR 산물의전기영동패턴에서밴드유무확인만으로도쉽고, 정확하게구별할수 있다.
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公开(公告)号：KR102169268B1
公开(公告)日：2020-10-23
申请号：KR1020190098601
申请日：2019-08-13
Applicant: 중앙대학교 산학협력단 , 대한민국 (식품의약품안전처장) , 인하대학교 산학협력단
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公开(公告)号：KR102093810B1
公开(公告)日：2020-03-26
申请号：KR1020180106032
申请日：2018-09-05
Applicant: 서울대학교산학협력단 , 대한민국 (식품의약품안전처장)
IPC: C12N5/0775 , G01N33/50
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