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    FLUORAPATITE-FORMING CALCIUM PHOSPHATE CEMENTS
    72.
    发明公开
    FLUORAPATITE-FORMING CALCIUM PHOSPHATE CEMENTS 审中-公开
    FLUOR APATIT-FINE磷酸钙骨水泥

    公开(公告)号：EP2588555A1

    公开(公告)日：2013-05-08

    申请号：EP11801486.9

    申请日：2011-07-01

    Applicant: ADA Foundation

    Inventor： CHOW, Laurence C. ,  TAKAGI, Shozo

    IPC: C09K3/00

    CPC classification number: C04B28/348 ,  C04B28/34 ,  C04B2111/00836 ,  C04B14/28 ,  C04B22/064 ,  C04B22/126

    Abstract: This study reports in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). Experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it biocompatible and bioinert CPC. These bioinert CPCs are candidates for use in useful applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

    ANTI-CARIOUS CHEWING GUMS, CANDIES, GELS, TOOTHPASTES AND DENTIFRICES
    74.
    发明授权
    ANTI-CARIOUS CHEWING GUMS, CANDIES, GELS, TOOTHPASTES AND DENTIFRICES 失效
    ANTI-KARÖSE口香糖，糖果，糖果，凝胶剂，牙膏和牙齿护理

    公开(公告)号：EP0952851B1

    公开(公告)日：2011-05-04

    申请号：EP97938396.5

    申请日：1997-08-19

    Applicant: ADA FOUNDATION

    Inventor： CHOW, Laurence, C. ,  TAKAGI, Shozo ,  VOGEL, Gerald, L.

    IPC: A61K47/00 ,  A61K9/68

    CPC classification number: A61Q11/00 ,  A23G3/362 ,  A23G4/064 ,  A61K8/19 ,  A61K8/24 ,  A61K9/0058

    Abstract: The invention relates to anticarious delivery vehicles, specifically chewing-gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.

    ENZYMATICALLY AND HYDROLYTICALLY STABLE DENTAL PREVENTIVE AND RESTORATIVE SYSTEMS
    76.
    发明申请
    ENZYMATICALLY AND HYDROLYTICALLY STABLE DENTAL PREVENTIVE AND RESTORATIVE SYSTEMS 审中-公开

    公开(公告)号：US20190209438A1

    公开(公告)日：2019-07-11

    申请号：US16356959

    申请日：2019-03-18

    Applicant: ADA Foundation

    Inventor： Jirun Sun ,  Rafael Lee Bowen

    IPC: A61K6/083

    Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula wherein n is an integer equal to or greater than 1 covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH2—CH2—O—) moieties and/or derivatives thereof, and one or more benzene derivatives; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

    COMPOSITION-CONTROLLED POLYMERS, METHODS OF FORMATION, AND USES THEREOF
    78.
    发明申请
    COMPOSITION-CONTROLLED POLYMERS, METHODS OF FORMATION, AND USES THEREOF 审中-公开

    公开(公告)号：US20190048116A1

    公开(公告)日：2019-02-14

    申请号：US16159616

    申请日：2018-10-13

    Applicant: ADA Foundation

    Inventor： Jirun Sun

    IPC: C08F236/20 ,  C08F212/08 ,  C08F220/14

    Abstract: A composition of matter includes a mixture of styrene derivative monomers and methacrylate/acrylate derivative monomers, which form hydrogen bonds between/among different precursors, and initiators, and the compositions are used to achieve composition control of the forming polymer, with the mole fraction of acrylate/methacrylate and styrene moieties in the forming polymer determined preferably by the monomer reactivity and monomer composition rather than the viscosity of the monomers.

    MATERIAL DEPOSITION DEVICE AND METHOD OF USE
    80.
    发明申请
    MATERIAL DEPOSITION DEVICE AND METHOD OF USE 有权
    材料沉积装置及其使用方法

    公开(公告)号：US20160157978A1

    公开(公告)日：2016-06-09

    申请号：US14561978

    申请日：2014-12-05

    Applicant: ADA FOUNDATION

    Inventor： Wojtek Tutak

    IPC: A61C19/06 ,  B05D1/02 ,  B05B7/00

    CPC classification number: A61C19/06 ,  A61C19/063 ,  A61L27/18 ,  A61L27/222 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/12 ,  B05B7/062 ,  B05B7/1606 ,  D01D4/025 ,  D01D4/027 ,  D01D5/14 ,  C08L67/04

    Abstract: A material deposition device includes a solution supply component, a gas supply component, and a co-axial discharge mechanism. The co-axial discharge mechanism includes a solution discharge mechanism, and a gas discharge mechanism co-axial with the solution discharge mechanism. The material deposition device further includes an alignment component that aligns the solution discharge mechanism in a center of the gas discharge mechanism; and an orifice plate with a number of turbulence inducing structures that induce turbulence in gas exiting the gas discharge mechanism.

    Abstract translation: 材料沉积装置包括溶液供应部件，气体供应部件和同轴排出机构。 同轴排放机构包括溶液排出机构和与排液机构同轴的气体排出机构。 所述材料沉积装置还包括对准部件，其将所述溶液排出机构对准所述气体排出机构的中心; 以及具有多个湍流诱导结构的孔板，其导致排出气体排出机构的气体中的湍流。

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