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    COMBINATION MONOPHASIC ACTION POTENTIAL/ABLATION CATHETER AND HIGH-PERFORMANCE FILTER SYSTEM
    71.
    发明申请
    COMBINATION MONOPHASIC ACTION POTENTIAL/ABLATION CATHETER AND HIGH-PERFORMANCE FILTER SYSTEM 审中-公开
    组合单相动作电位/吸收管和高性能过滤器系统

    公开(公告)号：WO1992021285A1

    公开(公告)日：1992-12-10

    申请号：PCT/US1992003142

    申请日：1992-04-16

    Applicant: EP TECHNOLOGIES, INC.

    Inventor： EP TECHNOLOGIES, INC. ,  EDWARDS, Stuart, D. ,  FRANZ, Michael, R. ,  THOMPSON, Russell, B. ,  STERN, Roger, A.

    IPC: A61B05/04

    CPC classification number: A61B18/1206 ,  A61B5/0422 ,  A61B18/12 ,  A61B18/1492 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/00473 ,  A61B2018/00107 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/0066 ,  A61B2018/00839 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1495 ,  A61B2018/1497 ,  A61B2018/162 ,  A61B2562/0215 ,  A61N1/056

    Abstract: A combination catheter for both detecting monophasic action potentials and ablating surface tissue in an in vivo heart of a patient is provided. The apparatus includes a catheter probe having a terminal tip portion (10) and an electrode (20) carried on the tip such that a portion of the tip electrode (20) is exposed to ambient. A reference electrode (50) is spaced along the tip from the first electrode for supplying a reference potential signal. An ablating electrode (30) is located adjacent to but electrically insulated from both the tip (20) and reference (50) electrodes for providing electromagnetic energy to the tip. The electrodes are electrically connected to the proximal end of the catheter through individual conductors or wires (22, 32, and 50) that run through an insulated cable. An electronic filter is provided to permit the recording of MAPs during ablation without radiofrequency interference. The catheter may also include standard mapping and/or pacing electrodes (80 and 75) respectively. The catheter may further include a steering mechanism for positioning the catheter at various treatment sites in the heart, and a structure for holding the tip electrode in substantially perpendicular contact with heart tissue with a positive pressure, and for spacing the reference electrode from the heart tissue.

    Abstract translation: 提供了用于检测患者的体内心脏中的单相动作电位和消融表面组织的组合导管。 该装置包括导管探头，其具有端子末端部分（10）和承载在尖端上的电极（20），使得尖端电极（20）的一部分暴露于环境中。 参考电极（50）沿着尖端与第一电极间隔开，用于提供参考电位信号。 烧蚀电极（30）位于与尖端（20）和参考电极（50）电极相邻但电绝缘的位置，用于向尖端提供电磁能。 电极通过穿过绝缘电缆的单个导体或导线（22,32和50）电连接到导管的近端。 提供电子滤波器以允许在消融期间MAP的记录而没有射频干扰。 导管还可以分别包括标准贴图和/或起搏电极（80和75）。 导管还可以包括用于将导管定位在心脏中的各种治疗部位的转向机构，以及用于将尖端电极与正常压力基本上垂直接触心脏组织并将参考电极与心脏组织间隔开的结构 。

    BRANCHED STRUCTURES FOR SUPPORTING MULTIPLE ELECTRODE ELEMENTS
    72.
    发明申请
    BRANCHED STRUCTURES FOR SUPPORTING MULTIPLE ELECTRODE ELEMENTS 审中-公开
    支持多个电极元件的分支结构

    公开(公告)号：WO1998026724A1

    公开(公告)日：1998-06-25

    申请号：PCT/US1997022997

    申请日：1997-12-11

    Applicant: EP TECHNOLOGIES, INC.

    Inventor： EP TECHNOLOGIES, INC. ,  WHAYNE, James, G.

    IPC: A61B17/36

    CPC classification number: A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00065 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2218/002 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/0163

    Abstract: A catheter assembly comprises a first branch (44) having a first axis, a second branch (32) extending in a non-parallel relationship with respect to the first axis and at least one electrode (28) carried by the second branch body (32). In use, the first branch body (44) can be located within a pulmonary vein within the left atrium, while the electrode (28) carried by the second branch body (32) is located in contact with endocardial tissue outside the pulmonary vein. Ablation energy can be transmitted from the electrode (28) to contacted endocardial tissue while the first branch (44) body is located within the pulmonary vein.

    Abstract translation: 导管组件包括具有第一轴线的第一分支（44）和相对于第一轴线以非平行关系延伸的第二分支（32）和由第二分支体（32）承载的至少一个电极（28） ）。 在使用中，第一分支体（44）可以位于左心房内的肺静脉内，而由第二分支体（32）承载的电极（28）位于与肺静脉外的心内膜组织接触。 当第一分支（44）体位于肺静脉内时，消融能量可以从电极（28）传递到接触心内膜组织。

    SYSTEMS AND METHODS FOR VISUALIZING INTERIOR TISSUE REGIONS
    73.
    发明申请
    SYSTEMS AND METHODS FOR VISUALIZING INTERIOR TISSUE REGIONS 审中-公开
    用于可视化内部组织区域的系统和方法

    公开(公告)号：WO1998018388A1

    公开(公告)日：1998-05-07

    申请号：PCT/US1997019373

    申请日：1997-10-27

    Applicant: EP TECHNOLOGIES, INC.

    Inventor： EP TECHNOLOGIES, INC. ,  McGEE, David ,  SWANSON, David, K. ,  TENHOFF, Harm ,  PANESCU, Dorin ,  WHAYNE, James, G.

    IPC: A61B08/12

    CPC classification number: A61B8/12 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7285 ,  A61B6/541 ,  A61B8/4461 ,  A61B8/4488 ,  A61B8/543 ,  A61B18/1492 ,  A61B2018/00208 ,  A61B2018/00214 ,  A61B2018/1861

    Abstract: An imaging element characterizes tissue morphology by analyzing perfusion patterns of a contrast media in tissue visualized by the imaging element, to identify infarcted tissue. In a preferred implementation, a catheter tube (12) introduced into a heart region carries the imaging element (34), as well as a support structure (20) spaced from the imaging element, which contracts endocardial tissues. The imaging element is moved as the imaging element visualizes tissue. A selected electrical event is sensed in surrounding myocardial tissue which regulates movement of the imaging element. The support element stabilizes the moving imaging element as it visualizes tissue, providing resistance to dislodgment or disorientation despite the presence of dynamic forces.

    Abstract translation: 成像元件通过分析由成像元件可视化的组织中的造影剂的灌注模式来表征组织形态，以鉴定梗死组织。 在优选的实施方案中，引入心脏区域的导管（12）携带成像元件（34）以及与成像元件间隔开的支架结构（20），其收缩心内膜组织。 当成像元件可视化组织时，成像元件移动。 在周围的心肌组织中感测出选择的电子事件，其调节成像元件的运动。 支撑元件在移动成像元件可视化组织时稳定运动成像元件，尽管存在动态力，但提供抵抗移动或定向障碍。

    MULTIPLE ELECTRODE SUPPORT STRUCTURES HAVING OPTIMAL BIO-MECHANICAL CHARACTERISTICS
    74.
    发明申请
    MULTIPLE ELECTRODE SUPPORT STRUCTURES HAVING OPTIMAL BIO-MECHANICAL CHARACTERISTICS 审中-公开
    具有最佳生物机械特性的多电极支撑结构

    公开(公告)号：WO1997017905A1

    公开(公告)日：1997-05-22

    申请号：PCT/US1996018332

    申请日：1996-11-12

    Applicant: EP TECHNOLOGIES, INC.

    Inventor： EP TECHNOLOGIES, INC. ,  KORDIS, Thomas, F. ,  PANESCU, Dorin ,  WHAYNE, James, G.

    IPC: A61B17/39

    CPC classification number: A61B5/6852 ,  A61B5/0422 ,  A61B5/6858 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00839 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1465 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056

    Abstract: An electrode support structure comprises a distal hub (48) and a proximal base (12) aligned along a major axis with the distal hub (48). An array of generally flexible spline elements (180) extends between the hub (48) and the base (12). The spline elements (180) each have an elongated axis that, at the base (12), extends generally parallel to the major axis and, at the hub (48), extends at an angle measured relative to the major axis of between 45 degrees and 110 degrees. The spline elements (180) collectively define a distal surface (66) lying within an envelope that approximates the curvature of endocardial tissue and within which envelope the distal hub (48) lies. According to this aspect of the invention, the distal surface (66), when contacting endocardial tissue, increases in surface area in response to force applied generally along the major axis to mediate tissue pressure.

    Abstract translation: 电极支撑结构包括远端轮毂（48）和沿着长轴与远侧轮毂（48）对准的近侧基座（12）。 大致柔性的花键元件（180）的阵列在轮毂（48）和基座（12）之间延伸。 所述花键元件（180）各自具有细长轴线，所述细长轴线在所述基部（12）处大体上平行于所述长轴线延伸，并且在所述轮毂（48）处以相对于所述长轴测量的角度之间延伸45度 和110度。 花键元件（180）共同地限定位于包络内的远侧表面（66），其近似心内膜组织的曲率，并且远端轮毂（48）位于该远端表面内。 根据本发明的这个方面，当远端表面（66）接触心内膜组织时，响应于通常沿着长轴施加的力而介导组织压力的表面积增加。

    SYSTEMS AND METHODS FOR MAKING TIME-SEQUENTIAL MEASUREMENTS OF BIOLOGICAL EVENTS
    77.
    发明申请
    SYSTEMS AND METHODS FOR MAKING TIME-SEQUENTIAL MEASUREMENTS OF BIOLOGICAL EVENTS 审中-公开
    制作生物事件时间序列测量的系统和方法

    公开(公告)号：WO1996025095A1

    公开(公告)日：1996-08-22

    申请号：PCT/US1996002090

    申请日：1996-02-14

    Applicant: EP TECHNOLOGIES, INC.

    Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K. ,  PANESCU, Dorin

    IPC: A61B05/0402

    CPC classification number: A61B5/6855 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/6858 ,  A61B2562/0209 ,  A61B2562/043 ,  A61N1/056 ,  A61N1/3702 ,  A61N1/403

    Abstract: Analog or digital systems (10) and methods generate a composite signal derived from a biological event in a time sequential fashion. A first set of signals derived from a biological event using a first group of sensors (20) during a first time interval is input. A second set of signals derived from the biological event during a second time interval sequentially after the first time interval using a second group of sensors (36) is input. The second group of sensors has at least one common sensor that is part of the first group and other sensors that are not part of the first group. The first and second sets of signals are time aligned using signals sensed by the at least one common sensor, thereby generating the composite signal. The time alignment is done by shifting the first and second sets of signals either with or without computing a time difference between them.

    Abstract translation: 模拟或数字系统（10）和方法以时间顺序的方式产生从生物事件导出的复合信号。 输入在第一时间间隔期间使用第一组传感器（20）从生物事件导出的第一组信号。 输入使用第二组传感器（36）在第一时间间隔之后的第二时间间隔期间从生物事件导出的第二组信号。 第二组传感器具有至少一个共同的传感器，其是第一组的一部分和不是第一组的一部分的其它传感器。 使用由至少一个公共传感器感测的信号来对第一和第二组信号进行时间对准，从而产生复合信号。 时间对准是通过移动第一和第二组信号来完成的，无论是否计算它们之间的时间差。

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