公开(公告)号：WO2009059170A3

公开(公告)日：2010-02-18

申请号：PCT/US2008082038

申请日：2008-10-31

Applicant: IDEXX LAB INC ,  KRAH EUGENE REGIS III ,  BEALL MELISSA ,  O'CONNOR THOMAS PATRICK JR ,  CHANDRASHEKAR RAMASWANY

Inventor： KRAH EUGENE REGIS III ,  BEALL MELISSA ,  O'CONNOR THOMAS PATRICK JR ,  CHANDRASHEKAR RAMASWANY

IPC: G01N33/554

CPC classification number: G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/552 ,  C07K14/29 ,  Y10S435/81

Abstract: The invention provides Ehrlichia canis antigens that can be used to detect E. canis infected animals regardless of whether the animals have been vaccinated for E. canis. The invention also provides compositions and methods for determining the presence of E. canis antigens and antibodies.

Abstract translation: 本发明提供了可用于检测犬埃里希体感染的动物的埃利希体犬抗原，而不管动物是否接种了犬埃里希氏体。 本发明还提供了用于确定犬埃里希氏体抗原和抗体的存在的组合物和方法。

公开(公告)号：WO2008156650A3

公开(公告)日：2009-09-03

申请号：PCT/US2008007366

申请日：2008-06-12

Applicant: IDEXX LAB INC ,  ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A

Inventor： ELSEMORE DAVID ALLEN ,  FLYNN LAURIE A

IPC: C12M1/34 ,  G01N33/569

CPC classification number: G01N33/5308

Abstract: A device, kit and method for detecting the presence or absence of hookworm antigens. The device, kit and method of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample that may be infected with one or more of roundworm, whipworm, tapeworm and heartworm, and whether or not hookworm ova are present in the sample. Further, the device, kit and method of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample excreted by a canine animal as early as nine days after the animal first becomes infected with hookworm.

Abstract translation: 用于检测钩虫抗原存在或不存在的装置，试剂盒和方法。 本发明的装置，试剂盒和方法可用于确认可能被蛔虫，鞭虫，绦虫和心脏虫中的一种或多种感染的粪便样品中是否存在钩虫，以及是否存在钩虫ova 在样品中。 此外，本发明的装置，试剂盒和方法可以用于在动物首先感染钩虫后9天确认犬动物排泄的粪便样品中是否存在钩虫。

公开(公告)号：WO2009039239A2

公开(公告)日：2009-03-26

申请号：PCT/US2008076788

申请日：2008-09-18

Applicant: IDEXX LAB INC ,  CARPENTER CHARLES ,  FARACE GIOSI ,  FARRELL ROBERT ,  NASSIF KEITH

Inventor： CARPENTER CHARLES ,  FARACE GIOSI ,  FARRELL ROBERT ,  NASSIF KEITH

IPC: G01N33/543 ,  G01N33/52 ,  G01N33/558

CPC classification number: G01N33/525 ,  G01N33/54366 ,  G01N33/558

Abstract: An apparatus, device, and method for laterally moving or assisting in the lateral movement of at least one of a liquid sample and a reagent along a porous carrier matrix is disclosed. The method comprises contacting the matrix with the at least one of the sample and the reagent and exposing the at least one of a liquid sample and a reagent to a centrifugal force, thereby moving or assisting in the lateral movement of the at least one of a liquid sample and a reagent along the porous carrier matrix.

Abstract translation: 公开了一种用于沿着多孔载体基质横向移动或辅助液体样本和试剂中的至少一个的横向移动的设备，装置和方法。 该方法包括使基质与样品和试剂中的至少一种接触，并将液体样品和试剂中的至少一种暴露于离心力，从而移动或帮助使至少一种液体样品和试剂的横向运动 液体样品和沿多孔载体基质的试剂。

公开(公告)号：WO2008045767A3

公开(公告)日：2008-05-29

申请号：PCT/US2007080507

申请日：2007-10-05

Applicant: IDEXX LAB INC ,  MAGNOTTI RALPH

Inventor： MAGNOTTI RALPH

IPC: G01N33/84

CPC classification number: G01N33/84 ,  G01N2800/347

Abstract: A method for determining the presence or amount of a gadolinium chelate in a biological sample. The method includes contacting a biological sample with a dye selected from arsenazo III or chlorophosphonazo at low pH, and measuring the absorbance of the sample, thereby determining the presence or amount of gadolinium in the sample. A method for determining glomerular filtration (GFR) rate in a mammal. The method includes administering to the mammal an amount of a gadolinium chelate and determining the concentration levels of the chelate in biological samples taken from the animal at plurality of intervals following administration of the chelate. The concentration levels of the chelate are correlated to GFR.

Abstract translation: 用于确定生物样品中钆螯合物的存在或量的方法。 该方法包括在低pH下使生物样品与选自偶氮胂III或偶氮磷腈的染料接触，并测量样品的吸光度，从而确定样品中钆的存在或量。 一种测定哺乳动物肾小球滤过率（GFR）的方法。 该方法包括向哺乳动物施用一定量的钆螯合物，并在施用螯合物后以多个时间间隔测定取自动物的生物样品中螯合物的浓度水平。 螯合物的浓度水平与GFR相关。

公开(公告)号：WO2007044304A3

公开(公告)日：2007-07-19

申请号：PCT/US2006038474

申请日：2006-10-03

Applicant: IDEXX LAB INC ,  RICH CARL RUSSELL

Inventor： RICH CARL RUSSELL

IPC: B04B15/00

CPC classification number: B01L3/5021 ,  B01L2200/026 ,  B01L2200/087 ,  B01L2200/143 ,  B01L2300/0681 ,  B04B5/0407 ,  B04B7/08 ,  B04B11/043

Abstract: A spinnable rotor for. a high speed centrifuge includes a housing which defines a chamber interiorly thereof for receiving a whole blood sample and for containing a predetermined amount of red blood cell absorbent gel. The housing includes an upper portion and a bottom portion, the upper portion having a port formed through the thickness thereof. The upper portion has at least a portion thereof formed from a light transmissible material. A light pipe is joined to the upper portion and light transmissively communicates with the light transmissive portion of the upper portion. The light pipe extends at least partially into the chamber and has an open, lower free end. When whole blood filling the rotor chamber contacts the lower free end of the light pipe, the red color of the blood is transmissively communicated to the upper portion of the rotor housing where it is viewable by the user of the centrifuge.

Abstract translation: 可旋转转子。 高速离心机包括壳体，其在其内部限定用于接收全血样品并容纳预定量的红细胞吸收凝胶的腔室。 壳体包括上部和底部，上部具有通过其厚度形成的端口。 上部具有由透光材料形成的至少一部分。 光管接合到上部，并且光与上部的透光部分透射连通。 光管至少部分地延伸到腔室中并具有开放的较低的自由端。 当全血填充转子室接触光管的下自由端时，血液的红色透射地传递到转子壳体的上部，在该壳体的上部可由离心机的使用者观察。

公开(公告)号：WO2005057170A3

公开(公告)日：2007-05-31

申请号：PCT/US2004040492

申请日：2004-12-03

Applicant: IDEXX LAB INC ,  RICH CARL RUSSELL ,  GRIFFIN JUSTIN JAY ,  LAWRENCE JONATHAN WILLIAM ,  GOLDMAN ROSS BRYAN

Inventor： RICH CARL RUSSELL ,  GRIFFIN JUSTIN JAY ,  LAWRENCE JONATHAN WILLIAM ,  GOLDMAN ROSS BRYAN

IPC: B01L3/00 ,  B32B5/02 ,  G01N20060101 ,  G01N35/00

CPC classification number: G01N35/00029 ,  G01N2035/00138

Abstract: A retaining clip for retaining reagent test slides in a stacked arrangement is formed as a unitary member and has first, second and third plates, each having an inner surface and an outer surface. The inner surface of the first plate pivots towards the inner surface of the second plate, and the inner surface of the third plate also pivots such that the inner surfaces of the first and third plates at least partially face each other upon pivoting. The inner surfaces of the first and third plates are separated by a distance to accommodate the reagent test slides in a stacked arrangement. Alternatively, the third and second plates can be fixed rigidly to each other with only the first plate pivoting to at least partially face the third plate upon pivoting.

Abstract translation: 用于将层叠布置的试剂滑块保持的保持夹具形成为整体构件，并且具有分别具有内表面和外表面的第一，第二和第三板。 第一板的内表面朝向第二板的内表面枢转，并且第三板的内表面也枢转，使得第一和第三板的内表面在枢转时至少部分地彼此面对。 将第一和第三板的内表面分开一段距离，以容纳叠置的试剂载玻片。 或者，第三板和第二板可以彼此刚性固定，只有第一板在枢转时枢转至少部分地面对第三板。

公开(公告)号：WO2006091824A3

公开(公告)日：2006-10-19

申请号：PCT/US2006006612

申请日：2006-02-24

Applicant: IDEXX LAB INC ,  KRAH EUGENE

Inventor： KRAH EUGENE

IPC: G01N33/569 ,  C07K14/08 ,  C07K16/10 ,  C12N15/40 ,  C12N15/62

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K2319/21 ,  C12N2770/10022 ,  G01N2469/10 ,  G01N2469/20

Abstract: The invention provides compositions and methods for the detection and quantification of PRRSV antibodies and antibody fragments using polypeptides.

Abstract translation: 本发明提供了使用多肽检测和定量PRRSV抗体和抗体片段的组合物和方法。

公开(公告)号：WO2006007202A2

公开(公告)日：2006-01-19

申请号：PCT/US2005018515

申请日：2005-05-26

Applicant: IDEXX LAB INC ,  BEALLS MELISSA

Inventor： BEALLS MELISSA

IPC: C07K14/435 ,  C07K14/705 ,  C07K14/74 ,  C07K16/28 ,  C12N5/06 ,  G01N33/50 ,  G01N33/53 ,  G01N33/564 ,  G01N33/567

CPC classification number: C07K16/2887 ,  C07K14/70596 ,  C07K2317/33 ,  G01N33/5052 ,  G01N33/564 ,  G01N2800/104

Abstract: The invention provides canine CD20 nucleotide and protein sequences. These compositions are useful in the diagnosis and treatment of, e.g., CD20+ B-cell lymphoma, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, and systemic lupus erythematosus (SLE) in canines and felines.

Abstract translation: 本发明提供了犬CD20核苷酸和蛋白质序列。 这些组合物可用于诊断和治疗例如犬和猫的CD20 + B细胞淋巴瘤，免疫介导的溶血性贫血，免疫介导的血小板减少症和系统性红斑狼疮（SLE）。

公开(公告)号：WO2005058169A3

公开(公告)日：2005-10-27

申请号：PCT/US2004042061

申请日：2004-12-15

Applicant: IDEXX LAB INC ,  MIKULKA THOMAS LUKE ,  DJURANOVIC NEVENA NOVKOVIC ,  BARSKI STANISLAW JR ,  LIBBY TRACY LYNN HESSEL

Inventor： MIKULKA THOMAS LUKE ,  DJURANOVIC NEVENA NOVKOVIC ,  BARSKI STANISLAW JR ,  LIBBY TRACY LYNN HESSEL

IPC: A61B10/00 ,  A61B10/02 ,  A61B17/32 ,  A61B19/00 ,  G01N1/08

CPC classification number: A61B10/0266 ,  A61B10/0283 ,  A61B17/32053 ,  A61B2090/061 ,  A61B2090/063 ,  A61B2090/3937

Abstract: The present disclosure provides for devices for obtaining a sample from inside a body. According to one embodiment, the device includes a tubular body portion (102) defining a chamber (104) for receiving a sample of material therein; a plunger assembly operatively associated with the tubular body portion, the plunger assembly having a stopper (124) slidably disposed within the chamber of the body portion; and feedback elements (140) provided on the tubular body and/or the plunger assembly for providing a user of the sampling device with audible and/or tactile indications regarding an amount of displacement of the plunger assembly relative to the body portion. The stopper is adapted for fluid tight engagement with the body portion. A cutting element (130) is also provided to facilitate sample removal.

Abstract translation: 本公开提供了用于从身体内部获取样品的装置。 根据一个实施例，该装置包括管状主体部分（102），其限定用于在其中容纳材料样本的腔室（104） 柱塞组件，其与所述管状主体部分可操作地相关联，所述柱塞组件具有可滑动地设置在所述主体部分的所述腔室内的止动件（124） 以及设置在管状主体和/或柱塞组件上的反馈元件（140），用于向采样装置的使用者提供关于柱塞组件相对于主体部分的位移量的可听和/或触觉指示。 塞子适于与主体部分流体紧密接合。 还提供切割元件（130）以便于去除样品。

公开(公告)号：WO2005024427A2

公开(公告)日：2005-03-17

申请号：PCT/US2004029266

申请日：2004-09-09

Applicant: IDEXX LAB INC ,  BEALL MELISSA ,  CHANDRASHEKAR RAMASWAMY

Inventor： BEALL MELISSA ,  CHANDRASHEKAR RAMASWAMY

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/18

Abstract: A method and device for determining whether an animal is infected with West Nile Virus (WN-V), or is either not infected or vaccinated with a WNV vaccine. The method includes contacting a biological sample from the subject with a first WNV polypeptide that is not an element of the WNV vaccine, and detecting whether antibodies in the sample bind to the WNV polypeptide. If the antibodies in the sample bind to the WNV polypeptide, it can be determined that the animal is naturally infected with WNV and if the antibodies do not bind to the polypeptide, it can be determined that the animal is either vaccinated or not infected.

Abstract translation: 一种用于确定动物是否感染西尼罗河病毒（WN-V）的方法和装置，或未被WNV疫苗感染或接种疫苗。 该方法包括使来自受试者的生物样品与不是WNV疫苗的元件的第一WNV多肽接触，并检测样品中的抗体是否与WNV多肽结合。 如果样品中的抗体与WNV多肽结合，则可以确定动物天然地被WNV感染，并且如果抗体不与多肽结合，则可以确定动物接种疫苗或未被感染。