Curcumin-boron complex and pharmaceutical containing same

    公开(公告)号:US10669287B2

    公开(公告)日:2020-06-02

    申请号:US16087017

    申请日:2017-03-21

    Abstract: Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.

    MEASUREMENT DEVICE AND IRRADIATION DEVICE
    72.
    发明申请

    公开(公告)号:US20200166457A1

    公开(公告)日:2020-05-28

    申请号:US16637011

    申请日:2018-08-09

    Abstract: According to the present invention, a measurement device includes a light emitting part configured to emit a plurality of spectral lights each including two or more spectra distributed at mutually different frequencies by causing adjacent frequency intervals to be different from each other, a focusing part configured to focus light by causing two or more spectra to overlap in an overlapping region in each of a plurality of different focal point regions of a sample and to be shifted from each other, and a detecting part configured to acquire a signal of fluorescence beats which emits light by interference light beats in each of a plurality of overlapping regions in the sample and includes information of the sample.

    Flow pattern regular expression creating method, regular expression creating apparatus, and computer-executable program

    公开(公告)号:US10540460B2

    公开(公告)日:2020-01-21

    申请号:US15524897

    申请日:2015-11-06

    Abstract: There is provided a flow pattern regular expression creating method, a regular expression creating apparatus, and a program enabling provision of a new representation method enabling one-to-one correspondence to a flow pattern. A regular expression creating method of creating a regular expression of a flow pattern in a multiply connected exterior domain with N (N is an integer equal to or larger than 1) holes topologically includes a graph representation creating step of creating a graph representation having one-to-one correspondence to the flow pattern; and a regular expression creating step of creating a regular expression from the graph representation that is created at the graph representation creating step.

    METHOD FOR MANUFACTURING THIN FILM TRANSISTOR

    公开(公告)号:US20190386151A1

    公开(公告)日:2019-12-19

    申请号:US16550161

    申请日:2019-08-23

    Abstract: A thin film transistor 100 according to the invention includes a gate electrode 20, a channel 44, and a gate insulating layer 34 provided between the gate electrode 20 and the channel 44 and made of oxide (possibly containing inevitable impurities; this applies to oxide hereinafter) containing lanthanum and zirconium. The channel 44 is made of channel oxide including first oxide containing indium, zinc, and zirconium (Zr) having an atomic ratio of 0.015 or more and 0.075 or less relative to indium assumed to be 1 in atomic ratio, second oxide containing indium and zirconium (Zr) having an atomic ratio of 0.055 or more and 0.16 or less relative to the indium (In) assumed to be 1 in atomic ratio, or third oxide containing indium and lanthanum having an atomic ratio of 0.055 or more and 0.16 or less relative to the indium (In) assumed to be 1 in atomic ratio.

    Sheet for pressure sensor, pressure sensor, and method for producing sheet for pressure sensor

    公开(公告)号:US10401240B2

    公开(公告)日:2019-09-03

    申请号:US15116003

    申请日:2015-02-05

    Abstract: In order to provide a highly flexible and more highly sensitive ultrathin sheet for a pressure sensor, a pressure sensor, and a method for producing the sheet for a pressure sensor, a pressure sensor sheet (10) of the present invention is provided with a first electrode sheet (1a), a second electrode sheet (1b), and a flocculent pressure-sensitive conductive layer (3) composed of tangled conductive fibers (2) which is disposed between the first electrode sheet (1a) and the second electrode sheet (1b) and undergoes a change in resistance value when compressed, wherein the conductive fibers (2) extend along a direction parallel to the two electrode sheets and are stacked in a perpendicular direction, and the conductive fibers that constitute the pressure-sensitive conductive layer have spaces provided therebetween.

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