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公开(公告)号：US10669287B2
公开(公告)日：2020-06-02
申请号：US16087017
申请日：2017-03-21
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Motomu Kanai , Yohei Soma , Jizhi Ni , Atsuhiko Taniguchi
Abstract: Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to Aβ peptides but also to other amyloids, and a preventive/therapeutic drug for an amyloid-related disease using the same. A curcumin-boron complex represented by the following formula (1): wherein X1 and X2 are identical or different, and each represent a halogenoalkyl group or a halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and each represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and each represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 are optionally taken together to form an optionally substituted alkylene group or alkenylene group; and m and n each represent an integer of 1 to 3, or a salt thereof.
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公开(公告)号：US20200166457A1
公开(公告)日：2020-05-28
申请号：US16637011
申请日：2018-08-09
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Takeshi YASUI , Tetsuo IWATA , Yasuhiro MIZUTANI , Takeo MINAMIKAWA , Takahiko MIZUNO , Eiji HASE , Hirotsugu YAMAMOTO
Abstract: According to the present invention, a measurement device includes a light emitting part configured to emit a plurality of spectral lights each including two or more spectra distributed at mutually different frequencies by causing adjacent frequency intervals to be different from each other, a focusing part configured to focus light by causing two or more spectra to overlap in an overlapping region in each of a plurality of different focal point regions of a sample and to be shifted from each other, and a detecting part configured to acquire a signal of fluorescence beats which emits light by interference light beats in each of a plurality of overlapping regions in the sample and includes information of the sample.
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公开(公告)号：US10540460B2
公开(公告)日：2020-01-21
申请号：US15524897
申请日：2015-11-06
Applicant: Japan Science and Technology Agency
Inventor： Takashi Sakajo , Tomoo Yokoyama
Abstract: There is provided a flow pattern regular expression creating method, a regular expression creating apparatus, and a program enabling provision of a new representation method enabling one-to-one correspondence to a flow pattern. A regular expression creating method of creating a regular expression of a flow pattern in a multiply connected exterior domain with N (N is an integer equal to or larger than 1) holes topologically includes a graph representation creating step of creating a graph representation having one-to-one correspondence to the flow pattern; and a regular expression creating step of creating a regular expression from the graph representation that is created at the graph representation creating step.
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74.发明授权公开(公告)号：US10538728B2
公开(公告)日：2020-01-21
申请号：US15512631
申请日：2015-11-04
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Yoko Yamanishi , Kazuki Takahashi , Shun Omi
Abstract: Provided is a bubble-jetting member, the tip section of which is not damaged even when high voltage is applied thereto.There can be provided a bubble jetting member comprising: a core that is formed of a conductive material; a shell part that is formed of an insulating material, includes an extended section that extends beyond the tip of the core, and is closely adhered at least partially to the core and covers the core; and a space that is formed between the extended section and the tip of the core and has a bubble-jetting port, wherein there is formed on the tip of the extended section a thick portion that is thicker than the rest of the extended section whereby the tip section is not damaged.
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公开(公告)号：US10513683B2
公开(公告)日：2019-12-24
申请号：US15104733
申请日：2014-12-16
Applicant: Japan Science and Technology Agency
Inventor： Hiroshi Sunami , Ikuko Yokota
Abstract: A structure used for animal cells is provided which includes an elastic body layer having a flat surface on which animal cells are left. The elastic body layer has a surface whose elasticity is changed by partially supporting the elastic body layer from the rear side or by changing a thickness of the elastic body layer.
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Patent Agency Ranking
公开(公告)号：US20190386151A1
公开(公告)日：2019-12-19
申请号：US16550161
申请日：2019-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Tatsuya SHIMODA , Satoshi INOUE , Tue Trong PHAN , Takaaki MIYASAKO , Jinwang Li
IPC: H01L29/786 , H01L29/66 , H01L29/49
Abstract: A thin film transistor 100 according to the invention includes a gate electrode 20, a channel 44, and a gate insulating layer 34 provided between the gate electrode 20 and the channel 44 and made of oxide (possibly containing inevitable impurities; this applies to oxide hereinafter) containing lanthanum and zirconium. The channel 44 is made of channel oxide including first oxide containing indium, zinc, and zirconium (Zr) having an atomic ratio of 0.015 or more and 0.075 or less relative to indium assumed to be 1 in atomic ratio, second oxide containing indium and zirconium (Zr) having an atomic ratio of 0.055 or more and 0.16 or less relative to the indium (In) assumed to be 1 in atomic ratio, or third oxide containing indium and lanthanum having an atomic ratio of 0.055 or more and 0.16 or less relative to the indium (In) assumed to be 1 in atomic ratio.
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公开(公告)号：US10444249B2
公开(公告)日：2019-10-15
申请号：US14908954
申请日：2014-04-11
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Takanori Fukushima , Fumitaka Ishiwari , Hanako Hasebe , Takao Someya , Tsuyoshi Sekitani
IPC: G01N33/00 , G01N33/84 , C08F220/30 , C08F220/34 , C07C69/017 , C07C69/54 , C07C219/34 , C08F220/06 , G01N21/64 , G01N31/22
Abstract: Provided is a compound including a repeating unit (A) having a carboxyl group on a side chain thereof and a repeating unit (B) having a carboxylate group having an ester residue exhibiting an aggregation-induced emission capability on a side chain thereof and the compound is useful as a polyvalent metal ion sensor such as calcium ions that is capable of reversible sensing and of being integrated into a device.
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公开(公告)号：US10431341B2
公开(公告)日：2019-10-01
申请号：US14437650
申请日：2013-10-15
Applicant: Japan Science and Technology Agency
Inventor： Kazuyuki Aihara , Luonan Chen , Rui Liu
Abstract: The invention provides a detection device, method, and program capable of highly accurately detecting a pre-disease state that indicates a precursor to a state transition from a healthy state to a disease state. The following processes are carried out: a process of obtaining measured data on genes, proteins, etc. related to a biological object as high-throughput data (s1), a process of selecting differential biological molecules (s2), a process of calculating the SNE of a local network (s3), a process of selecting a biomarker candidate (s4), a process of calculating an average SNE across the entire network (s5), and a process of determining and detecting whether or not the system is in a pre-disease state (s6).
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79.发明授权公开(公告)号：US10413247B2
公开(公告)日：2019-09-17
申请号：US14767976
申请日：2014-02-14
Applicant: Japan Science and Technology Agency
Inventor： Hiroshi Fuketa , Makoto Takamiya , Takayasu Sakurai , Tsuyoshi Sekitani , Takao Someya
IPC: A61B5/0492 , A61B5/0488 , A61B5/00 , A61B5/04
Abstract: A signal detection device includes: multiple electrodes that are arranged to come into contact with a subject that generates a signal; an electrode signal selection unit that alternatively selects one signal from signals on the multiple electrodes based on a selection signal; an amplification unit that amplifies the signal that is selected by the electrode signal selection unit; and a flexible substrate on which the multiple electrodes, the selection unit, and the amplification unit are formed, in which the amplification unit is formed on the substrate to form a laminated structure together with the multiple electrodes and the selection unit.
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80.发明授权公开(公告)号：US10401240B2
公开(公告)日：2019-09-03
申请号：US15116003
申请日：2015-02-05
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Sung Won Lee , Takao Someya , Tsuyoshi Sekitani
Abstract: In order to provide a highly flexible and more highly sensitive ultrathin sheet for a pressure sensor, a pressure sensor, and a method for producing the sheet for a pressure sensor, a pressure sensor sheet (10) of the present invention is provided with a first electrode sheet (1a), a second electrode sheet (1b), and a flocculent pressure-sensitive conductive layer (3) composed of tangled conductive fibers (2) which is disposed between the first electrode sheet (1a) and the second electrode sheet (1b) and undergoes a change in resistance value when compressed, wherein the conductive fibers (2) extend along a direction parallel to the two electrode sheets and are stacked in a perpendicular direction, and the conductive fibers that constitute the pressure-sensitive conductive layer have spaces provided therebetween.
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