公开(公告)号：US20220008450A1

公开(公告)日：2022-01-13

申请号：US17281810

申请日：2019-09-27

Applicant: DAIKIN INDUSTRIES, LTD. ,  KAGOSHIMA UNIVERSITY

Inventor： Tomohito HAMADA ,  Yosuke KISHIKAWA ,  Kanako INOO ,  Masanori IKEDA ,  Midori TAKEDA

IPC: A61K31/7076 ,  A61P31/20

Abstract: The present disclosure provides an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-related diseases, each comprising a nucleic acid analogue as an active ingredient. The problem can be solved by 2′-deoxy-2′-fluoro-β-2-fluoro-D-adenosine or its prodrug, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

公开(公告)号：US11198106B2

公开(公告)日：2021-12-14

申请号：US16640588

申请日：2018-08-08

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takayuki Takei ,  Masahiro Yoshida ,  Yoshihiro Ohzuno ,  Gen Hayase

IPC: B01J13/14

Abstract: An object of the invention is to provide a method for producing a capsule or microbead having high encapsulation efficiency of an encapsulated substance, high production efficiency, and high versatility. The invention relates to a method for producing a microcapsule or microbead, comprising: a step of disposing a monomer droplet or polymer droplet containing a substance to be encapsulated, which has a surface coated with a plurality of solid fine particles, on a flat surface; and a step of solidifying the monomer droplet or polymer droplet disposed on the flat surface in a gas phase so as to form an outer shell of a capsule or microbead, thereby forming a region enclosed by the outer shell, wherein the substance is encapsulated in the region.

公开(公告)号：US20210174763A1

公开(公告)日：2021-06-10

申请号：US16613740

申请日：2018-05-16

Applicant: Kagoshima University

Inventor： Sakuichi Ohtsuka

IPC: G09G5/10

Abstract: A tone adjustment unit assumes that the following relationship is satisfied: Lo=Do+Da=TD(I)+Da=TL(I), in which I represents a luminance value normalized to have a maximum value of one in first image data, Do represents a luminance value normalized to have a maximum value of one in second image data, Da represents a luminance value under ambient light during viewing, Lo represents a luminance value of the second image data while taking into consideration effects of the ambient light during viewing, TD(I) represents a tone curve used for conversion, and TL(I) represents a tone curve taking into consideration the environment. The tone curve TD(I) is adjusted so that a function representing an inclination γ(I) after converting Lo=TL(I) to a double logarithmic plot is non-zero over an entire dynamic range.

公开(公告)号：US20210147512A1

公开(公告)日：2021-05-20

申请号：US16620715

申请日：2018-05-18

Applicant: Kagoshima University

Inventor： Yuji Ito

IPC: C07K16/00 ,  C07K14/00

Abstract: It is an object of the present invention to provide a method for modifying an antibody in a specific and simple manner, and others. The present invention relates to: an IgG-binding peptide, an IgG-binding peptide modified with a crosslinking agent, a complex of an IgG-binding peptide modified with the crosslinking agent and IgG, a method for producing the complex, and others.

公开(公告)号：US10882005B2

公开(公告)日：2021-01-05

申请号：US15748069

申请日：2016-07-25

Applicant: Kagoshima University

Inventor： Yoshihiro Hirata ,  Taro Shimonosono ,  Hikari Imada

IPC: B01D53/22 ,  C01B3/50 ,  B01D71/02 ,  C04B35/575 ,  C04B37/00 ,  C04B35/111 ,  B01D67/00 ,  C04B35/486 ,  B01D69/02 ,  C01B3/56 ,  C04B35/10 ,  C04B35/48 ,  C04B35/565 ,  C04B38/00

Abstract: A hydrogen gas producing apparatus includes a porous body (100) and a mixed gas source (300). The porous body (100) is permeable to hydrogen gas and carbon dioxide gas, and has a property of being more permeable to hydrogen gas than carbon dioxide gas. The mixed gas source (300) causes a mixed gas including carbon dioxide gas and hydrogen gas to flow into the porous body (100) under a condition that a pressure gradient represented by (P1−P2)/L is below 50 MPa/m, where L represents the length of the porous body (100) in a direction in which the mixed gas permeates; P1 represents an inflow pressure of the mixed gas into the porous body (100); and P2 represents an outflow pressure thereof from the porous body (100).

公开(公告)号：US20200171454A1

公开(公告)日：2020-06-04

申请号：US16640588

申请日：2018-08-08

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takayuki TAKEI ,  Masahiro YOSHIDA ,  Yoshihiro OHZUNO ,  Gen HAYASE

IPC: B01J13/14

Abstract: An object of the invention is to provide a method for producing a capsule or microbead having high encapsulation efficiency of an encapsulated substance, high production efficiency, and high versatility. The invention relates to a method for producing a microcapsule or microbead, comprising: a step of disposing a monomer droplet or polymer droplet containing a substance to be encapsulated, which has a surface coated with a plurality of solid fine particles, on a flat surface; and a step of solidifying the monomer droplet or polymer droplet disposed on the flat surface in a gas phase so as to form an outer shell of a capsule or microbead, thereby forming a region enclosed by the outer shell, wherein the substance is encapsulated in the region.

公开(公告)号：US20200060579A1

公开(公告)日：2020-02-27

申请号：US16489311

申请日：2018-03-01

Applicant: Kagoshima University

Inventor： Tomonori Iwasaki ,  Youichi Yamasaki

IPC: A61B5/085 ,  A61B6/03 ,  G06T7/00 ,  G06T17/00 ,  G16H50/50

Abstract: A nasal-cavity model generator (41) extracts pixels having pixel density values within a specific range from three-dimensional image data on a nasal cavity of a subject contained in DICOM data (21), and generates a nasal cavity model (50), which is a three-dimensional model of the nasal cavity, based on three-dimensional image data composed of the extracted pixels. A nasal-cavity resistance calculator (42) calculates a nasal cavity resistance (51) through fluid analysis using the nasal cavity model (50) generated by the nasal-cavity model generator (41). An adjuster (43) adjusts the specific range of the pixel density values of the pixels to be extracted for generation of the nasal cavity model (50) by the nasal-cavity model generator (41) such that the nasal cavity resistance (51) calculated by the nasal-cavity resistance calculator (42) is equal to a nasal cavity resistance (52) actually measured with a nasal-cavity draft gauge.

公开(公告)号：US10517928B2

公开(公告)日：2019-12-31

申请号：US15503078

申请日：2015-08-06

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Akio Ido ,  Hirohito Tsubouchi ,  Yuga Komaki

IPC: A61K38/18 ,  A61L31/16 ,  A61L31/04 ,  A61P1/04

Abstract: According to this invention, the following are provided: a pharmaceutical composition for treating and/or preventing esophageal stenosis, comprising an HGF protein as an active ingredient (wherein the HGF protein may be a polypeptide that is any one of the following: (a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence shown in SEQ ID NO: 2 in which one to several amino acids are deleted, substituted, or added; or (c) a polypeptide comprising an amino acid sequence having at least 90% identity with the amino acid sequence shown in SEQ ID NO: 2; and a stent comprising the pharmaceutical composition.

公开(公告)号：US20190389803A1

公开(公告)日：2019-12-26

申请号：US16479081

申请日：2018-01-16

Applicant: Kagoshima University ,  Nobelpharma Co., Ltd.

Inventor： Masanori BABA ,  Masaaki TOYAMA ,  Norikazu SAKAKIBARA

IPC: C07D215/44 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  A61P31/12

Abstract: The present invention pertains to an antiviral drug for severe fever with thrombocytopenia syndrome, which contains a compound represented by formula (I) or a salt thereof, or a solvate of the compound or salt (In the formula, R1 and R2 are the same or different from each other, and each represents a substituted or unsubstituted C1-10 alkyl group, R1 and R2 may form a substituted or unsubstituted 5- or 6-member ring in conjunction with an adjacent nitrogen atom, and X represent a halogen atom.)

公开(公告)号：US20190275481A1

公开(公告)日：2019-09-12

申请号：US16320458

申请日：2017-07-21

Applicant: Kagoshima University

Inventor： Takashi Goshima

IPC: B01F11/02 ,  B01F3/04 ,  B01F15/00 ,  B01F5/06

Abstract: A bubble generation device includes: a metallic narrow tube (10) through which water passes; and a pump that pressure-feeds the water containing a gas component into the metallic narrow tube (10). A drawer (11) in which a path through which the water passes is narrower than the front and the rear thereof in the flow direction of the water is disposed on the inside of the metallic narrow tube (10). The drawer (11) has the rectangular cross section orthogonal to the flow direction. The gas component contained in the water is dissolved in the water by pressure-feeding the water to the drawer (11), bubbles are evolved due to a decrease in pressure in the drawer (11), turbulent flow is generated in the water in the drawer (11) to crush bubbles in the water by the shearing force thereof, and bubbles are crushed by a shock wave caused by transonic flow occurring in the water that has exited from the drawer (11).