公开(公告)号：US20250161529A1

公开(公告)日：2025-05-22

申请号：US18843155

申请日：2023-02-27

Applicant: Kagoshima University

Inventor： Takayuki TAKEI ,  Masahiro YOSHIDA ,  Yusuke YAMASHITA

IPC: A61L26/00

Abstract: Provided is a method of preparing a medical hydrogel derived from a chitosan derivative containing aldonic acid bound by dehydration condensation to an amino group of a glucosamine unit of chitosan, the method including placing an aqueous solution containing the chitosan derivative in a mold having a predetermined shape, and then subjecting the aqueous solution to high-pressure steam sterilization, to obtain a sterile medical hydrogel having the predetermined shape. The resulting medical hydrogel can be used as a wound dressing for use in the treatment of wound surfaces of cut wounds, lacerated wounds, contused wounds, burns, bedsores, and the like.

公开(公告)号：US20170216444A1

公开(公告)日：2017-08-03

申请号：US15514886

申请日：2015-10-19

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Tsutomu TAMAI ,  Takayuki TAKEI ,  Akio IDO ,  Masahiro YOSHIDA ,  Shinji SAKAI

IPC: A61K47/42 ,  A61K47/36 ,  A61K47/32 ,  A61K31/555 ,  A61K47/08 ,  A61K38/54 ,  A61K38/44 ,  A61K47/38 ,  A61K47/30

CPC classification number: A61K47/42 ,  A61K9/0019 ,  A61K31/00 ,  A61K31/555 ,  A61K38/44 ,  A61K38/443 ,  A61K38/54 ,  A61K45/00 ,  A61K47/08 ,  A61K47/30 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/46 ,  A61L24/0015 ,  A61L24/04 ,  A61L2300/416 ,  A61L2400/06 ,  A61L2430/36 ,  A61M5/00

Abstract: An object is to provide a preparation for forming emboli highly safe in a living body and capable of retaining and controlled-releasing an anticancer agent, occluding a blood vessel when injected into the blood vessel, unlikely to be washed out and having a controlled decomposition time (i.e., occludes a blood vessel for a while and quickly decomposes to prevent the necrosis of the entire tissues when the function is completed). The preparation for forming emboli according to the present invention comprises a solution comprising a phenolic hydroxyl group-modified polymer represented by the following formula (1): wherein P is a biocompatible polymer, A is a single bond or an —OCO—C2-C4-alkenylene group, a —CONH—C1-C4-alkylene group or an —HNCO—C1-C4-alkylene group, and X is hydrogen or a C1-C3-alkoxy group, a solution comprising at least one selected from a peroxidase, a laccase, a tyrosinase, a catalase and an iron porphyrin complex and a solution comprising hydrogen peroxide.

公开(公告)号：US20240359152A1

公开(公告)日：2024-10-31

申请号：US18569175

申请日：2022-06-10

Applicant: Kagoshima University

Inventor： Takayuki TAKEI ,  Masahiro YOSHIDA ,  Yoshihiro OHZUNO

IPC: B01J13/16 ,  B01J2/02

CPC classification number: B01J13/16 ,  B01J2/02

Abstract: A tubular body (111) has a shape of tube surrounding a virtual center line (VL). A guide groove (112) that is helical about the virtual center line (VL) is provided in the inner surface of the tubular body (111). A rotation device (120) rotates the tubular body (111) around the virtual center line (VL). A dropping device (130) drops, on the inner surface of the tubular body (111), an inclusion substance and a wall material precursor liquid that is a precursor of a wall material covering the inclusion substance. A liquid droplet dropped by the dropping device (130) rolls in the guide groove (112) of the tubular body (111), the tubular body (111) being rotated by the rotation device (120).

公开(公告)号：US20240301171A1

公开(公告)日：2024-09-12

申请号：US18274389

申请日：2022-01-27

Applicant: KAGOSHIMA UNIVERSITY ,  Tokuyama Corporation

Inventor： Masahiro YOSHIDA ,  Takayuki TAKEI ,  Yoshihiro OHZUNO ,  Kengo NISHIO ,  Yasutomo SHIMIZU ,  Kazuishi FUKUDA ,  Takayoshi KAWASAKI

IPC: C08K7/22 ,  B01J13/16 ,  B24B37/24

CPC classification number: C08K7/22 ,  B01J13/16 ,  B24B37/24 ,  C08K2201/003

Abstract: The fine hollow particle of the present invention is a fine hollow particle composed of a resin film comprising a melamine-based resin, in which the resin film is composed of a plurality of small piece-shaped portions and a bonding portion for bonding the plurality of small piece-shaped portions. According to the present invention, it is possible to provide stable fine hollow particles having excellent solvent resistance and heat resistance, good dispersibility, and a large particle diameter.

公开(公告)号：US20200171454A1

公开(公告)日：2020-06-04

申请号：US16640588

申请日：2018-08-08

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Takayuki TAKEI ,  Masahiro YOSHIDA ,  Yoshihiro OHZUNO ,  Gen HAYASE

IPC: B01J13/14

Abstract: An object of the invention is to provide a method for producing a capsule or microbead having high encapsulation efficiency of an encapsulated substance, high production efficiency, and high versatility. The invention relates to a method for producing a microcapsule or microbead, comprising: a step of disposing a monomer droplet or polymer droplet containing a substance to be encapsulated, which has a surface coated with a plurality of solid fine particles, on a flat surface; and a step of solidifying the monomer droplet or polymer droplet disposed on the flat surface in a gas phase so as to form an outer shell of a capsule or microbead, thereby forming a region enclosed by the outer shell, wherein the substance is encapsulated in the region.