公开(公告)号：WO2017181045A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027680

申请日：2017-04-14

Applicant: LIGHTLAB IMAGING, INC.

Inventor： GOPINATH, Ajay

IPC: G06T7/11

Abstract: In part, the disclosure relates to an automated method of branch detection with regard to a blood vessel imaged using an intravascular modality such as OCT, IVUS, or other imaging modalities. In one embodiment, a representation of A-lines and frames generated using an intravascular imaging system is used to identify candidate branches of a blood vessel. One or more operators such as filters can be applied to remove false positives associated with other detections.

Abstract translation: 部分地，本公开涉及关于使用诸如OCT，IVUS或其他成像模态的血管内模态成像的血管的分支检测的自动化方法。 在一个实施例中，使用血管内成像系统生成的A线和帧的表示被用于识别血管的候选分支。 一个或多个操作员（如过滤器）可用于消除与其他检测相关的误报。

公开(公告)号：WO2017087477A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062213

申请日：2016-11-16

Applicant: LIGHTLAB IMAGING, INC.

Inventor： AMBWANI, Sonal

IPC: A61B5/00

CPC classification number: A61B5/4851 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B5/6862

Abstract: In part, the disclosure relates to methods of stent strut detection relative to a side branch region using intravascular data. In one embodiment, detecting stent struts relative to jailed side branches is performed using a scan line-based peak analysis. In one embodiment, false positive determinations relating to stent struts are analyzed using a model strut.

Abstract translation: 部分地，本公开涉及使用血管内数据相对于侧支区域进行支架支柱检测的方法。 在一个实施例中，使用基于扫描线的峰值分析来执行相对于被监禁侧支路的支架支柱的检测。 在一个实施例中，使用模型支柱分析与支架支柱有关的假阳性确定。

公开(公告)号：WO2017066108A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056216

申请日：2016-10-10

Applicant: LIGHTLAB IMAGING, INC.

Inventor： GOPINATH, Ajay ,  KHAN, Subhan ,  DION, Denis

IPC: A61B5/00 ,  A61B5/02

CPC classification number: A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/489 ,  A61B5/6852 ,  A61B2576/02 ,  G06T19/00 ,  G06T2210/41 ,  G06T2219/008

Abstract: In part, the disclosure relates to intravascular data collections and generation of representations thereof include one or more view of regions associated with side branches or arteries such as a carina or bifurcation. In one embodiment, accessing a set of intravascular data stored in machine readable memory; performing side branch detection with regard to the intravascular data to identify one or more side branches; and identifying a plurality of frames for the one or more side branches is performed. An automatic viewing angle that is toggleable via a user interface is used in one embodiment.

Abstract translation: 部分地，本公开涉及血管内数据收集，并且其表示的生成包括与侧分支或动脉相关的区域（例如隆凸或分叉）的一个或多个视图。 在一个实施例中，访问存储在机器可读存储器中的一组血管内数据; 对血管内数据进行侧分支检测以识别一个或多个侧分支; 并且执行识别用于一个或多个侧分支的多个帧。 在一个实施例中使用经由用户界面可切换的自动视角。

公开(公告)号：WO2016210132A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/039019

申请日：2016-06-23

Applicant: LIGHTLAB IMAGING, INC.

Inventor： LIU, Yu

IPC: A61B5/00 ,  G02B3/00

CPC classification number: A61B5/0084 ,  A61B3/102 ,  A61B5/0066 ,  G02B3/0087 ,  G02B6/4206 ,  G02B6/4212

Abstract: In part, the disclosure relates to a lens assembly. The lens assembly can be used to direct light for sensing and imaging. In one embodiment, the lens assembly is a component of an intravascular data collection probe such as an optical coherence tomography probe. The lens assembly can include an optical fiber having a first diameter and a gradient index lens that includes a rod having a length L. The rod can include a substantial planar end and a polished end. The rod can include a longitudinal axis and a second diameter. The second diameter is greater than the first diameter in one embodiment. The substantially planar end is optically coupled to an endface of the optical fiber. The refractive index changes along the length L of the rod.

Abstract translation: 部分地，本公开涉及一种透镜组件。 透镜组件可用于引导光线进行感测和成像。 在一个实施例中，透镜组件是血管内数据收集探针的组件，例如光学相干断层摄影探针。 透镜组件可以包括具有第一直径的光纤和包括具有长度L的杆的梯度折射率透镜。杆可以包括实质的平面端部和抛光端部。 杆可以包括纵向轴线和第二直径。 在一个实施例中，第二直径大于第一直径。 基本上平面的端部光耦合到光纤的端面。 折射率沿棒的长度L变化。

公开(公告)号：WO2016187218A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/032908

申请日：2016-05-17

Applicant: LIGHTLAB IMAGING, INC.

Inventor： GRIFFIN, Christopher E. ,  AMBWANI, Sonal ,  PETERSON, James G. ,  KAVETI, Satish ,  FRIEDMAN, Joel M.

IPC: A61B5/06 ,  A61B5/00 ,  G06T7/00

CPC classification number: G06T7/0012 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/06 ,  A61B5/6852 ,  G06K9/4647 ,  G06K2209/05 ,  G06T7/70 ,  G06T2207/10068 ,  G06T2207/10101 ,  G06T2207/30021 ,  G06T2207/30052 ,  G06T2207/30101

Abstract: In part, the disclosure relates to intravascular data collection systems and angiography systems and the exchange of data between two or more of the foregoing and the generation and display of diagnostic information such as indicators. One or more indicators can be generated and displayed such as by overlaying or otherwise combining such indicators with images generated using an intravascular data collection system. The indicators can include longitudinal, cross-sectional, and other indictor types such as one more indicator or graphical elements suitable for indicating diagnostic information of interest. Indicators can be used to guide a user during stent delivery planning and other actions. The disclosure also relates to stent detection and shadow detection in the context of intravascular data sets obtained using a probe such as, for example, and optical coherence tomography probe or an intravascular ultrasound probe.

Abstract translation: 在一部分中，本公开涉及血管内数据收集系统和血管造影系统以及前述两个或更多个之间的数据交换以及诸如指示符的诊断信息的生成和显示。 可以生成和显示一个或多个指示符，例如通过将这些指示器与使用血管内数据收集系统生成的图像重叠或以其他方式组合。 指示器可以包括纵向，横截面和其他指示符类型，例如适于指示感兴趣的诊断信息的一个或多个指示符或图形元素。 指标可用于指导用户在支架输送计划和其他行动。 本公开还涉及在使用诸如例如光学相干断层扫描探针或血管内超声探针的探针获得的血管内数据集的上下文中的支架检测和阴影检测。

公开(公告)号：WO2016094909A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/065626

申请日：2015-12-14

Applicant: LIGHTLAB IMAGING, INC. ,  GOPINATH, Ajay ,  ADLER, Desmond

Inventor： GOPINATH, Ajay ,  ADLER, Desmond

IPC: A61B5/00 ,  A61B5/02

CPC classification number: G06T7/13 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B6/504 ,  A61B6/5217 ,  G06T5/50 ,  G06T7/12 ,  G06T11/60 ,  G06T19/20 ,  G06T2200/08 ,  G06T2207/10101 ,  G06T2207/20104 ,  G06T2207/20224 ,  G06T2207/30101 ,  G06T2210/41 ,  G06T2211/404 ,  G06T2219/2012

Abstract: In part, the disclosure relates to method for identifying regions of interest in a blood vessel. The method includes the steps of: providing OCT image data of the blood vessel; applying a plurality of different edge detection filters to the OCT image data to generate a filter response for each edge detection filter; identifying in each edge detection filter response any response maxima; combining the response maxima for each edge detection filter response while maintaining the spatial relationship of the response maxima, to thereby create edge filtered OCT data; and analyzing the edge filtered OCT data to identify a region of interest, the region of interest defined as a local cluster of response maxima. In one embodiment, one or more indicia are positioned in one or more panels to emphasize a reference vessel profile as part of a user interface.

Abstract translation: 在一部分中，本公开涉及用于识别血管中的感兴趣区域的方法。 该方法包括以下步骤：提供血管的OCT图像数据; 将多个不同的边缘检测滤波器应用于OCT图像数据以为每个边缘检测滤波器生成滤波器响应; 识别每个边缘检测滤波器响应任何响应最大值; 组合每个边缘检测滤波器响应的响应最大值，同时保持响应最大值的空间关系，从而创建边缘滤波OCT数据; 并分析边缘滤波的OCT数据以识别感兴趣的区域，所述感兴趣区域被定义为响应最大值的局部簇。 在一个实施例中，将一个或多个标记定位在一个或多个面板中以强调作为用户界面的一部分的参考血管简档。

公开(公告)号：WO2014077870A8

公开(公告)日：2015-06-11

申请号：PCT/US2013024620

申请日：2013-02-04

Applicant: LIGHTLAB IMAGING INC

Inventor： HUTCHINS CHRISTOPHER ,  ATLAS MICHAEL ,  BARNES TERRENCE

IPC: A61B8/14

CPC classification number: A61B8/4416 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B8/12 ,  A61B2562/0204 ,  A61B2562/0233

Abstract: In part, the invention relates to a probe suitable for use with image data collection system. The probe, in one embodiment, includes an optical transceiver, such as a beam director, and an acoustic transceiver such as an ultrasound transducer. The optical transceiver is in optical communication with an optical fiber in optical communication with a beam director configured to transmit light and receive scattered light from a sample such as a wall of a blood vessel. The acoustic transceiver includes an ultrasound device or subsystem such as a piezoelectric element configured to generate acoustic waves and receive reflected acoustic waves from the sample.

Abstract translation: 本发明的一部分涉及适用于图像数据采集系统的探针。 在一个实施例中，探针包括诸如波束导向器的光收发器和诸如超声换能器的声收发器。 光收发器与光导体光通信，该光纤与光束导向器进行光通信，光束导向器配置为透射光并接收来自诸如血管壁的样品的散射光。 声收发器包括超声装置或子系统，例如被配置为产生声波并从样本接收反射的声波的压电元件。

公开(公告)号：WO2014163601A1

公开(公告)日：2014-10-09

申请号：PCT/US2013/030166

申请日：2013-03-11

Applicant: LIGHTLAB IMAGING, INC.

Inventor： CHRISTOPHER, Petroff

IPC: A61B5/00 ,  A61B8/12 ,  F16D7/02 ,  F16D43/21

CPC classification number: A61B8/445 ,  A61B5/0066 ,  A61B5/0084 ,  A61B8/12 ,  A61B8/4461 ,  A61M25/0138 ,  A61M25/0147 ,  F16D7/021 ,  F16D43/211

Abstract: The invention provides a frictional torque limiter assembly for an imaging core spinning in a patient's body. The torque limiter assembly torsionally isolates the imaging core from a motor that spins the imaging core. An interference fit between a slitted drive tube and a spacer tube acts as a clutch that allows a spinning imaging probe to slow or stop relative to the motor until the motor is stopped, thereby preventing an unsafe condition.

Abstract translation: 本发明提供一种用于在患者体内旋转的成像芯的摩擦扭矩限制器组件。 扭矩限制器组件扭转地将成像芯与旋转成像芯的电机隔离。 狭缝式驱动管和间隔管之间的过盈配合用作离合器，其允许旋转成像探针相对于电动机减慢或停止，直到电动机停止，从而防止不安全的状况。

公开(公告)号：WO2014142815A1

公开(公告)日：2014-09-18

申请号：PCT/US2013/030622

申请日：2013-03-12

Applicant: LIGHTLAB IMAGING, INC.

Inventor： ADLER, Desmond ,  GOMES, Joshua, M. ,  WINSTON, David ,  MOYNIHAN, Susan

IPC: A61B8/00 ,  A61B6/00 ,  A61B5/00

CPC classification number: A61B5/0066 ,  A61B5/7425 ,  A61B5/743 ,  A61B5/7475 ,  A61B6/0457 ,  A61B6/4411 ,  A61B6/4441 ,  A61B6/4464 ,  A61B6/467 ,  A61B8/4411 ,  A61B8/461 ,  A61B8/467 ,  A61B2090/3735 ,  A61B2090/3782 ,  A61B2560/0425 ,  A61B2560/0487 ,  G06F19/00

Abstract: A data collection system controller (10) that includes a housing (12, 14) such as a cover. The housing includes a user facing section (30) and a support facing section (40) defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob (50) comprising a third input device (55) and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint.

Abstract translation: 一种数据采集系统控制器（10），其包括诸如盖子的壳体（12,14）。 壳体包括面向用户的部分（30）和限定孔的支撑面向部分（40）。 控制器还包括与用户面对部分相邻的第一输入装置和第二输入装置。 第二输入装置包括一个包括第三输入装置（55）的旋钮（50）和延伸穿过该孔部分地设置在该旋钮内的旋转轴。 在一个实施例中，第二输入装置是具有按钮的XYZ操纵杆。 在一个实施例中，操纵杆和第一输入装置在肘关节的任一侧上相对于彼此成角度。

公开(公告)号：WO2014077870A1

公开(公告)日：2014-05-22

申请号：PCT/US2013/024620

申请日：2013-02-04

Applicant: LIGHTLAB IMAGING, INC.

Inventor： HUTCHINS, Christopher ,  ATLAS, Michael ,  BARNES, Terrence

IPC: A61B8/14

CPC classification number: A61B8/4416 ,  A61B5/0035 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B8/12 ,  A61B2562/0204 ,  A61B2562/0233

Abstract: In part, the invention relates to a probe suitable for use with image data collection system. The probe, in one embodiment, includes an optical transceiver, such as a beam director, and an acoustic transceiver such as an ultrasound transducer. The optical transceiver is in optical communication with an optical fiber in optical communication with a beam director configured to transmit light and receive scattered light from a sample such as a wall of a blood vessel. The acoustic transceiver includes an ultrasound device or subsystem such as a piezoelectric element configured to generate acoustic waves and receive reflected acoustic waves from the sample.

Abstract translation: 本发明的一部分涉及适用于图像数据采集系统的探针。 在一个实施例中，探针包括诸如波束导向器的光收发器和诸如超声换能器的声收发器。 光收发器与光导体光通信，该光纤与光束导向器进行光通信，光束导向器配置为透射光并接收来自诸如血管壁的样品的散射光。 声收发器包括超声装置或子系统，例如被配置为产生声波并从样本接收反射的声波的压电元件。