公开(公告)号：US20010029041A1

公开(公告)日：2001-10-11

申请号：US09785764

申请日：2001-02-16

Applicant: St. Louis University

Inventor： Robert B. Belshe ,  Frances K. Newman

IPC: A61K039/12 ,  C12N007/08

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  C12N2760/18734 ,  C12N2760/18764

Abstract: The present invention relates to isolated, attenuated viral strains of human parainfluenza virus 2 (HPIV-2), which are useful in live vaccine preparations. These strains exhibit a temperature sensitive and cold adapted phenotype useful for stimulating a protective immune response in an inoculated mammal without producing severe symptoms.

Abstract translation: 本发明涉及可用于活疫苗制剂的人副流感病毒2（HPIV-2）的分离的减毒病毒株。 这些菌株表现出温度敏感和冷适应表型，其可用于在接种的哺乳动物中刺激保护性免疫应答而不产生严重症状。

公开(公告)号：US20030180791A1

公开(公告)日：2003-09-25

申请号：US10443982

申请日：2003-05-23

Applicant: ST. LOUIS UNIVERSITY

Inventor： Govindaswamy Chinnadurai

IPC: C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47

CPC classification number: C07K16/18 ,  C07K14/4747 ,  C07K2319/00

Abstract: A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.

Abstract translation: 通过允许细胞存活来抑制细胞凋亡的Bcl-2的结构域在突变时允许细胞增殖。 野生型结构域包括Bcl-2的氨基酸残基51至97（SEQ ID NO：13）。 包括结构域和编码该结构域的核苷酸的肽可用于人肿瘤的分子筛选，用于存在允许另外标记为细胞凋亡的细胞增殖的突变。 肽也可用于筛选在细胞增殖调节中起作用的蛋白质。

公开(公告)号：US20020087075A1

公开(公告)日：2002-07-04

申请号：US10068064

申请日：2002-02-05

Applicant: St. Louis University

Inventor： Richard D. Bucholz

IPC: A61B005/05

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/061 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/061 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3979 ,  A61B2090/3983 ,  A61B2090/3995

Abstract: A system for determining a position of a probe relative to an object such as a head of a body of a patient. The head includes a surface such as a forehead having a contour. Cross sectional images of the head are scanned and stored as a function of the forehead contour. If the forehead contour does not appear in the scan images, then the position of the forehead contour relative to the scan images is determined with an optical scanner and a ring. During surgery, the optical scanner also determines the position of the forehead relative to the ring. An array for receiving radiation emitted from the probe and from the ring generates signals indicating the position of the tip of the probe relative to the ring. A stereotactic imaging system generates and displays an image of the head corresponding to the measured position of the tip of the probe. The system may also display scan images from different scanning technologies which scan images correspond to the same position in the head.

公开(公告)号：US20180085431A1

公开(公告)日：2018-03-29

申请号：US15659570

申请日：2017-07-25

Applicant: St. Louis University

Inventor： Rajeev Aurora ,  Anna Smith ,  Angel Baldan

IPC: A61K38/17

CPC classification number: A61K38/177 ,  A61K38/1709

Abstract: Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

公开(公告)号：US20040199068A1

公开(公告)日：2004-10-07

申请号：US10826436

申请日：2004-04-16

Applicant: St. Louis University

Inventor： Richard D. Bucholz ,  D. Douglas Miller

IPC: A61B005/05

CPC classification number: A61N5/1049 ,  A61B5/0555 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1055 ,  A61N2005/1087

Abstract: A method which coordinates proton beam irradiation with an open magnetic resonance imaging (MRI) unit to achieve near-simultaneous, noninvasive localization and radiotherapy of various cell lines in various anatomic locations. A reference image of the target aids in determining a treatment plan and repositioning the patient within the MRI unit for later treatments. The patient is located within the MRI unit so that the target and the proton beam are coincident. MRI monitors the location of the target. Target irradiation occurs when the target and the proton beam are coincident as indicated by the MRI monitoring. The patient rotates relative to the radiation source. The target again undergoes monitoring and selective irradiation. The rotation and selective irradiation during MRI monitoring repeats according to the treatment plan.

Abstract translation: 用开放磁共振成像（MRI）单元协调质子束照射的方法，以实现各种解剖位置中各种细胞系的近同时，非侵入性定位和放射治疗。 目标的参考图像有助于确定治疗计划并将患者重新定位在MRI单元内用于后续治疗。 患者位于MRI单元内，使靶和质子束重合。 MRI监测目标的位置。 当靶标和质子束如MRI监测所示相同时，发生目标照射。 患者相对于辐射源旋转。 目标再次进行监测和选择性照射。 MRI监测中的旋转和选择性照射根据治疗计划重复。

公开(公告)号：US20040101741A1

公开(公告)日：2004-05-27

申请号：US10617452

申请日：2003-07-11

Applicant: St. Louis University

Inventor： Shelley D. Minteer ,  Niki L. Akers ,  Christine M. Moore

IPC: H01M004/90 ,  H01M004/96 ,  H01M008/10 ,  C12N011/08

CPC classification number: H01M8/1023 ,  C12N11/08 ,  C12Q1/004 ,  C12Q1/32 ,  H01M4/90 ,  H01M8/1039 ,  H01M8/1088 ,  H01M8/16 ,  H01M2300/0082 ,  Y02E60/527 ,  Y02P70/56

Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nafionnull polymer membrane and a dehydrogenase incorporated within the treated Nafionnull polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.

Abstract translation: 公开了包含季铵盐处理的聚合物膜和掺入处理的聚合物内的脱氢酶的生物过程。 脱氢酶催化有机燃料的氧化并且还原腺嘌呤二核苷酸。 离子导电聚合物膜与多亚甲基绿色氧化还原聚合物膜并置，其用于电还原腺嘌呤二核苷酸的电氧化。 生物阳极用于燃料电池中以产生高功率密度。

公开(公告)号：US10586692B2

公开(公告)日：2020-03-10

申请号：US16167806

申请日：2018-10-23

Applicant: Florida State University Research Foundation, Inc. ,  St. Louis University

Inventor： Michael G. Roper ,  James L. Edwards

IPC: H01J49/00 ,  H01J49/16 ,  G01N30/72 ,  H01J49/42 ,  H01J49/04 ,  G01N30/62

Abstract: Provided herein are methods for multiplexed sample analysis by mass spectrometry. The methods may be performed without the need for chemical tagging. The methods also may include the analogous use of frequency modulation to multiplex mass spectrometric analysis, which may be referred to as frequency-modulated continuous flow analysis electrospray ionization mass spectrometry (FM-CFA-ESI-MS).

公开(公告)号：US10328123B2

公开(公告)日：2019-06-25

申请号：US15659570

申请日：2017-07-25

Applicant: St. Louis University

Inventor： Rajeev Aurora ,  Anna Smith ,  Angel Baldan

IPC: A61K38/17

Abstract: Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

公开(公告)号：US20020183615A1

公开(公告)日：2002-12-05

申请号：US10197337

申请日：2002-07-16

Applicant: St. Louis University

Inventor： Richard D. Bucholz

IPC: A61B005/05 ,  A61B019/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

Abstract: A system for use in imaging a subject and determining a position relative to a body of a patient. A base is fixed in relation to the subject. An imaging probe is configured to scan the subject and provide scan images of the subject. An array of receivers is in communication with the base and the imaging probe. A first plurality of reference points is fixed in relation to the base and in communication with the array. A second plurality of reference points is fixed in relation to the imaging probe and in communication with the array. A processor in communication with the imaging probe and the array calculates the position in the scan images corresponding to the position of the imaging probe relative to the subject.

Abstract translation: 一种用于成像对象并确定相对于患者身体的位置的系统。 相对于受试者，基座是固定的。 成像探针被配置为扫描对象并提供被摄体的扫描图像。 一组接收器与基座和成像探头连通。 第一多个参考点相对于基座固定并与阵列通信。 第二多个参考点相对于成像探针固定并与阵列通信。 与成像探针和阵列通信的处理器计算与成像探针相对于被摄体的位置对应的扫描图像中的位置。