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    Polymeric Nanoparticles for Enhancing HIFU-Induced Ablation
    74.
    发明申请
    Polymeric Nanoparticles for Enhancing HIFU-Induced Ablation 审中-公开

    公开(公告)号：US20180185485A1

    公开(公告)日：2018-07-05

    申请号：US15740194

    申请日：2016-07-01

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： Mangala SRINIVAS ,  Carl Gustav FIGDOR ,  Ingrid Jolanda Monique DE VRIES

    IPC: A61K41/00 ,  A61K49/22 ,  A61N7/02

    CPC classification number: A61K41/0028 ,  A61K49/222 ,  A61N7/02

    Abstract: In the field of medical therapy, more in particular in the field of ablation therapy using ultrasound, such as high intensity focused ultrasound (HIFU), devices and methods are disclosed for enhancing the ablation effect of HIFU. More in particular, a polymeric particle is disclosed, including a polymer entrapping a liquid perfluorocarbon for use in high frequency ultrasound (HIFU) ablation therapy in a human or animal body, wherein the HIFU is focused in a focal region, wherein the ablation effect of the HIFU in the focal region is enhanced by administering the particles to the human or animal body, and the liquid perfluorocarbon does not undergo a phase change from liquid to gas during exposure to the HIFU.

    Aminomethylene pyrazolones with therapeutic activity
    75.
    发明授权
    Aminomethylene pyrazolones with therapeutic activity 有权

    公开(公告)号：US09790205B2

    公开(公告)日：2017-10-17

    申请号：US15590797

    申请日：2017-05-09

    Applicant: Compound Handling B.V. ,  Stichting Katholieke Universiteit

    Inventor： Onno Van Hooij ,  Jacobus Antonius Schalken ,  Hendrik Engelbertus Vietor ,  Dennis Patrick Piet ,  Petrus Emmanuel Marie Maas ,  Johann Heinrich Tijhuis ,  Sirik Deerenberg ,  Nanda Elisabeth Sprenkels ,  Siu Ha Tang

    IPC: A61K31/4155 ,  C07D403/04 ,  A61K31/4184

    CPC classification number: C07D403/04 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/454 ,  A61K45/06 ,  C07D417/04 ,  C07D417/14

    Abstract: A compound having the structure according to formula III wherein: X is NH or S; R1 is H or (1C-4C)alkyl; R2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro; R3 and R4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, a monocyclic non-aromatic ring having one or more N—, O— or S— atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N—, O— or S— atoms in the ring, whereby each of these optional substituents is optionally further substituted with (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, halogen, nitro or (1C-2C)dioxol forming a ring; or R3 and R4 form together pyrrolyl, imidazolyl, pyrazolyl, pyrrolidinyl, pyrrolinylimidazolidinyl, imidazolinyl, piperidyl, piperazinylmorpholinyl, each optionally substituted with (1C-6C)alkyl, phenyl(1C-4C)alkyl, phenylketo(1C-4C)alkyl; R5 is H, Cl, F, Br, Me, NO2, t-butyl, OCF3, OCH3, CF3; R6 is H, (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, nitro or halogen; R7 is H, F, Cl, Br, Me, NO2, t-butyl, OCF3, OCH3, CF3; or pharmaceutically acceptable addition salts thereof for use in treatments of carcinoma, in particular, to delay, prevent or reverse metastasis in prostate cancer.

    PCA3 genes
    77.
    发明授权
    PCA3 genes 有权
    PCA3基因

    公开(公告)号：US09540696B2

    公开(公告)日：2017-01-10

    申请号：US14033699

    申请日：2013-09-23

    Applicant: Stichting Katholieke Universiteit, more particularly The University Medical Centre Nijmegen

    Inventor： Marion J. G. Bussemakers ,  William B. Isaacs

    IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C07K14/47 ,  A61K38/00

    CPC classification number: C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.

    Abstract translation: 本发明一般涉及前列腺特异性抗原PCA3。 特别地，本发明涉及编码PCA3蛋白的核酸分子; 纯化的PCA3蛋白和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有与PCA3蛋白和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码PCA3蛋白质的核酸的核酸探针; 检测样品中编码PCA3蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有前列腺癌的哺乳动物; 治疗用途; 以及预防动物中前列腺癌的方法。

    JOINT PROSTHESIS ASSEMBLY
    78.
    发明申请
    JOINT PROSTHESIS ASSEMBLY 审中-公开
    联合会议大会

    公开(公告)号：US20160235538A1

    公开(公告)日：2016-08-18

    申请号：US15028042

    申请日：2014-01-27

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： Tony George VAN TIENEN

    IPC: A61F2/30 ,  A61B17/56

    CPC classification number: A61F2/30756 ,  A61B17/562 ,  A61F2/30 ,  A61F2/3872 ,  A61F2220/0008

    Abstract: A joint prosthesis assembly, includes a joint prosthesis body (1) made of a first biocompatible non-resorbable material and an anchoring element (2-5) made of a second biocompatible non-resorbable material. The anchoring element (2-5) is arranged to allow rotation of an end portion of the joint prosthesis body (1) with respect to the anchoring element (2-5) when in situ.

    Abstract translation: 一种关节假体组件，包括由第一生物相容性不可吸收材料制成的关节假体（1），以及由第二生物相容性不可吸收材料制成的锚定元件（2-5）。 锚定元件（2-5）被布置成当原位时允许关节假体（1）的端部相对于锚固元件（2-5）旋转。

    POLYMER SUITABLE FOR USE IN CELL CULTURE
    79.
    发明申请
    POLYMER SUITABLE FOR USE IN CELL CULTURE 审中-公开
    聚合物适用于细胞培养

    公开(公告)号：US20160137977A1

    公开(公告)日：2016-05-19

    申请号：US14905579

    申请日：2014-07-16

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： Alan Edward ROWAN ,  Zaskia Hillet EKSTEEN AKEROYD ,  Christopher WILSON ,  Petrus Johannes GEUTJES ,  Wouter F.J. FEITZ ,  Egbert OOSTERWIJK

    IPC: C12N5/071 ,  C07K5/062

    CPC classification number: C12N5/069 ,  C07K5/06026 ,  C08G65/325 ,  C08G65/33324 ,  C08G69/10 ,  C08G69/40 ,  C12N5/0691 ,  C12N2502/28 ,  C12N2533/50

    Abstract: A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin-strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol-carboxylic acid coupling resulting in esters linkages and NHS-Ester (N-Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.

    Abstract translation: 制备低聚（亚烷基二醇）官能化的共聚异氰尿苷的方法，其中该方法包括以下步骤：i）将接枝有连接基团的寡（亚烷基二醇）官能化异氰尿酸的第一共聚单体与非共轭聚异构体的第二共聚单体共聚， 接枝的寡聚（亚烷基二醇）官能化的异氰尿苷，其中第一共聚单体和第二共聚单体之间的摩尔比为1:500和1:30，和ii）将间隔单元的反应物和细胞粘附因子加入到由 步骤i），其中所述间隔单元由通式ALB表示，其中选择连接基团和基团A进行反应并形成第一偶联，并且选择细胞粘附因子和组B反应并形成第二偶联，其中 第一耦合和第二耦合独立地选自由炔 - 叠氮偶合，二苯并环辛烯 - 叠氮偶合，氧基雄烯二烯基叠氮化物偶联，viny 砜硫醇偶联，马来酰亚胺 - 硫醇偶联，甲基丙烯酸甲酯 - 硫醇偶联，醚偶联，硫醚偶联，生物素 - 链霉亲和素偶联，胺 - 羧酸引起酰胺键，产生酯键的醇 ​​- 羧酸偶联和NHS-酯（ N-羟基琥珀酰亚胺酯） - 胺偶联，其中基团L是在主链中选自C，N，O和S的原子之间具有10-60个键的直链链段。

    RAPID CYCLE DYNAMIC NUCLEAR POLARIZATION MAGNETIC RESONANCE APPARATUS
    80.
    发明申请
    RAPID CYCLE DYNAMIC NUCLEAR POLARIZATION MAGNETIC RESONANCE APPARATUS 有权
    快速循环动态核偏振磁共振仪

    公开(公告)号：US20150008917A1

    公开(公告)日：2015-01-08

    申请号：US14368011

    申请日：2012-12-21

    Applicant: Stichting Katholieke Universiteit

    Inventor： Arnold Peter Maria Kentgens ,  Petrus Johannes Maria van Bentum

    IPC: G01R33/48 ,  G01N33/50 ,  G01R33/31

    CPC classification number: G01R33/48 ,  G01N33/50 ,  G01R33/282 ,  G01R33/302 ,  G01R33/307 ,  G01R33/31 ,  G01R33/3456 ,  G01R33/465 ,  G01R33/62

    Abstract: A rapid cycle dynamic nuclear polarization (DNP) NMR apparatus comprises (i) a cooling unit, configured to cool a sample in a capillary, (b) a DNP polarization unit configured to polarize the sample in the capillary, (c) a stripline-based NMR detector comprising a stripline for NMR analysis of the sample in the capillary, (d) a transport unit configured to guide the capillary from the DNP polarization unit to the stripline of stripline-based NMR detector; and (e) a heating unit configured to heat the sample in the capillary before analysis of the sample by the stripline-based NMR detector. Fast (1D-3D) NMR measurements with high resolution may be obtained.

    Abstract translation: 快速循环动态核极化（DNP）NMR装置包括（i）冷却单元，其被配置为冷却毛细管中的样品，（b）构造成使毛细管中的样品偏振的DNP偏振单元，（c）带状线 - 该核磁共振检测器包括用于毛细管中的样品的NMR分析的带状线，（d）传送单元，其被配置为将毛细管从DNP偏振单元引导到基于带状线的NMR检测器的带状线; 和（e）加热单元，其构造成在通过基于带状线的NMR检测器分析样品之前加热毛细管中的样品。 可以获得具有高分辨率的快速（1D-3D）NMR测量。

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