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    APNEA AND HYPOPNEA DETECTION USING BREATH PATTERN RECOGNITION
    76.
    发明专利
    APNEA AND HYPOPNEA DETECTION USING BREATH PATTERN RECOGNITION 未知

    公开(公告)号：CA2836164C

    公开(公告)日：2021-06-22

    申请号：CA2836164

    申请日：2012-05-17

    Applicant: UNIV HEALTH NETWORK

    Inventor： ALSHAER HISHAM ,  FERNIE GEOFFREY ROY ,  BRADLEY T DOUGLAS

    IPC: A61B5/08 ,  A61B5/083

    Abstract: Disclosed herein is a method and device for apnea and hypopnea detection. In one embodiment, a method is provided for detecting apneas and hypopneas from a digitized breath sound recording acquired from a candidate suspected of sleep apnea. The method comprises scanning an amplitude profile of the digitized breath sound recording to identify a prospect event segment; evaluating characteristics of the prospect event segment for consistency with one or more preset apnea-specific criteria; classifying the prospect event segment as representative of an apnea upon it satisfying each of the one or more apnea-specific criteria; evaluating the prospect event characteristics for consistency with one or more preset hypopnea-specific criteria distinct from the apnea-specific criteria; and classifying the prospect event segment as representative of a hypopnea upon it satisfying each of the one or more hypopnea-specific criteria.

    Métodos y composiciones para evaluar injertos pulmonares
    78.
    发明专利
    Métodos y composiciones para evaluar injertos pulmonares 未知

    公开(公告)号：ES2831400T3

    公开(公告)日：2021-06-08

    申请号：ES14754767

    申请日：2014-02-20

    Applicant: UNIV HEALTH NETWORK

    Inventor： KESHAVJEE SHAF ,  LIU MINGYAO ,  CYPEL MARCELO

    IPC: G01N33/68

    Abstract: Método para clasificar un injerto pulmonar sometido a perfusión pulmonar ex vivo (PPEV) normotérmica, durante la perfusión y/o después de la perfusión, comprendiendo el método: a) recoger una muestra de ensayo del injerto pulmonar, en donde el injerto pulmonar es de un donante en muerte cardíaca (DMC); b) medir un nivel de polipéptido de un producto génico predictor de endotelina seleccionado de endotelina 1 (ET-1) y ET-1 grande en la muestra de ensayo; e c) identificar el injerto pulmonar como un buen candidato para trasplante o como un mal candidato para trasplante, en donde un nivel de polipéptido aumentado del producto génico predictor de endotelina en comparación con un control de pronóstico es indicativo de que el injerto es un mal candidato para trasplante.

    T CELL RECEPTORS AND METHODS OF USE THEREOF
    79.
    发明专利
    T CELL RECEPTORS AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3146302A1

    公开(公告)日：2021-02-04

    申请号：CA3146302

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： HIRANO NAOTO ,  SUGATA KENJI ,  SASO KAYOKO

    IPC: C12N15/867 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/113 ,  C12N15/12 ,  C12N15/63

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a MUC5AC epitope and nucleic acid molecules encoding the same. In some aspects, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some aspects, the methods comprise treating a cancer in a subject in need thereof.

    MHC CLASS II MOLECULES AND METHODS OF USE THEREOF
    80.
    发明专利
    MHC CLASS II MOLECULES AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3146292A1

    公开(公告)日：2021-02-04

    申请号：CA3146292

    申请日：2020-07-29

    Applicant: UNIV HEALTH NETWORK

    Inventor： HIRANO NAOTO ,  SUGATA KENJI

    IPC: C07K14/74

    Abstract: The present disclosure is directed to HLA class II molecules having a higher affinity for CD4 than naturally occurring HLA class II molecules. In certain aspects, the HLA class II molecule comprises a DQ beta chain having (i) an amino acid other than leucine at a position corresponding to amino acid residue 114 of SEQ ID NO: 1, (ii) an amino acid other than valine at a position corresponding to amino acid residue 143 of SEQ ID NO: 1, (iii) or both (i) and (ii). Certain aspects of the present disclosure are directed to nucleic acid molecules encoding the HLA class II molecules, vectors comprising the nucleic acid molecule, cells comprising the same, and methods of use thereof.

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