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    APPARATUS AND METHODS FOR PREPARATION AND ANALYSIS OF DRIED SAMPLES OF A BIOLOGICAL FLUID
    71.
    发明申请
    APPARATUS AND METHODS FOR PREPARATION AND ANALYSIS OF DRIED SAMPLES OF A BIOLOGICAL FLUID 审中-公开
    生物流体干燥样品的制备与分析装置及方法

    公开(公告)号：WO2011153122A2

    公开(公告)日：2011-12-08

    申请号：PCT/US2011/038494

    申请日：2011-05-31

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  JUNG, Moon Chul ,  BOUVIER, Edouard S. P. ,  GERHARDT, Geoff, C.

    Inventor： JUNG, Moon Chul ,  BOUVIER, Edouard S. P. ,  GERHARDT, Geoff, C.

    CPC classification number: B01L3/5023 ,  B01L2300/0822 ,  G01N1/405 ,  G01N30/06 ,  G01N30/16 ,  G01N2001/288 ,  G01N2001/4088 ,  G01N2030/009 ,  G01N2030/062

    Abstract: Described is a device for collecting a fluid sample, such as a biological fluid sample. The device includes a planar collection substrate having an absorbent material. The planar collection substrate includes an impermeable region and a sample collection region. The impermeable region is impermeable to the fluid sample and is embedded in the planar collection substrate in a spatial pattern. The sample collection region is in an area excluded from the spatial pattern and has a shape and a size defined by the spatial pattern. The sample collection region is configured to receive a known volume of the fluid sample. In an alternative form, the device includes a sample collection element disposed in an impermeable planar holder and, in another alternative form, the device includes an absorbent material disposed inside an impermeable tube wall.

    Abstract translation: 描述了用于收集诸如生物流体样品的流体样品的装置。 该装置包括具有吸收材料的平面收集基板。 平面收集基板包括不可渗透区域和样品收集区域。 不渗透区域对于流体样品是不可渗透的，并以空间图案嵌入在平面收集基板中。 样本收集区域处于从空间图案排除的区域中，并且具有由空间图案定义的形状和尺寸。 样品收集区域被配置为接收已知体积的流体样品。 在替代形式中，该装置包括设置在不可渗透的平面保持器中的样品收集元件，并且在另一替代形式中，该装置包括设置在不可渗透管壁内部的吸收材料。

    ON-LINE SAMPLING FORM A PROCESS SOURCE
    72.
    发明申请
    ON-LINE SAMPLING FORM A PROCESS SOURCE 审中-公开
    在线采样方式来源

    公开(公告)号：WO2011106162A1

    公开(公告)日：2011-09-01

    申请号：PCT/US2011/024292

    申请日：2011-02-10

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  CORMIER, Sylvain

    Inventor： CORMIER, Sylvain

    IPC: G01N21/53

    CPC classification number: G01N30/20 ,  G01N1/38 ,  G01N30/18 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/0318 ,  Y10T137/85978

    Abstract: An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.

    Abstract translation: 液相色谱系统的在线样品管理器包括具有第一入口端口，第二入口端口和出口端口的流体三通管。 稀释剂泵将稀释剂从稀释剂源移动到流体三通的第一入口端口。 阀具有连接到用于从其获取处理样品的处理源的流体入口。 泵送系统将获取的过程样品从阀门移动到流体三通的第二入口端口，其中过程样品与到达第一入口端口的稀释剂合并，以产生从流体出口端口流出的稀释过程样品 开球。

    SAMPLE TRAY WITH MAGNETICALLY CLOSING DRAWER
    73.
    发明申请
    SAMPLE TRAY WITH MAGNETICALLY CLOSING DRAWER 审中-公开
    带有磁力关闭抽屉的样品盘

    公开(公告)号：WO2011085342A1

    公开(公告)日：2011-07-14

    申请号：PCT/US2011/020749

    申请日：2011-01-11

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  BURNETT, Joshua, A. ,  USOWICZ, James, E. ,  GAGNE, Daniel, J. ,  MCGRATH, Keith ,  DENECKE, Frank

    Inventor： BURNETT, Joshua, A. ,  USOWICZ, James, E. ,  GAGNE, Daniel, J. ,  MCGRATH, Keith ,  DENECKE, Frank

    IPC: G01N30/02

    CPC classification number: G01N30/24 ,  G01N30/16 ,  G01N30/20 ,  G01N2035/00287 ,  G01N2035/00346 ,  G01N2035/0498

    Abstract: A sample manager of a liquid chromatography system uses a sample tray having a base with side walls separated by a cross wall that divides the base into two compartments. The side walls and cross wall bound each compartment on three sides. A fourth side of each compartment is open. Each compartment is sized to closely receive a sample-vial carrier. Each compartment has a magnet affixed to a bottom surface at an edge of the open fourth side. Each of two drawers slides into the open fourth side of one compartment. Each drawer has a support surface with a magnet affixed at an edge of its bottom side, which aligns with the magnet affixed to the bottom surface of the compartment. The magnet of the drawer and the magnet of the compartment bias the drawer into its compartment when the magnets are brought into proximity of each other.

    Abstract translation: 液相色谱系统的样品管理器使用具有底部的样品盘，其侧壁由跨壁分隔，所述横壁将基部分成两个隔室。 侧墙和十字墙三面分隔每个隔间。 每个隔间的第四面是敞开的。 每个隔室的大小可以紧密接收样品瓶载体。 每个隔室具有固定到开放的第四侧边缘处的底表面的磁体。 两个抽屉中的每一个都滑入一个隔间的敞开的第四侧。 每个抽屉具有一个支撑表面，一个磁体固定在其底部的边缘，它与固定在隔室底面上的磁体对准。 当磁体彼此靠近时，抽屉的磁体和室的磁体将抽屉偏置到其隔间中。

    SELF-SEALING SAMPLE COMPARTMENT FOR A LIQUID CHROMATOGRAPHY SYSTEM
    74.
    发明申请
    SELF-SEALING SAMPLE COMPARTMENT FOR A LIQUID CHROMATOGRAPHY SYSTEM 审中-公开
    用于液相色谱系统的自密封样品瓶

    公开(公告)号：WO2011085340A1

    公开(公告)日：2011-07-14

    申请号：PCT/US2011/020737

    申请日：2011-01-11

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  GAGNE, Daniel, J. ,  SHREVE, Joshua, A. ,  USOWICZ, James, E.

    Inventor： GAGNE, Daniel, J. ,  SHREVE, Joshua, A. ,  USOWICZ, James, E.

    IPC: G01N30/60

    CPC classification number: G01N30/04 ,  G01N30/54 ,  G01N2030/3084

    Abstract: Described is a self-sealing thermal enclosure. In various embodiments, the self-sealing thermal enclosure includes an enclosure having a wall with an opening. The enclosure is configured to surround a temperature-controlled environment. The self-sealing thermal enclosure also includes a porous seal disposed adjacent to the wall at the opening. The porous seal is compressible and is fabricated from an open cell foam material. When the porous seal has absorbed a fluid such as a condensate, the temperature-controlled environment is sealed from an ambient environment such that the flow of air into or out of the enclosure is substantially reduced or eliminated.

    Abstract translation: 描述了一种自密封热封装。 在各种实施例中，自密封热封套包括具有开口的壁的外壳。 外壳配置为围绕温度控制的环境。 自密封热封壳还包括邻近开口处的壁布置的多孔密封件。 多孔密封是可压缩的，并由开孔泡沫材料制成。 当多孔密封件已经吸收了诸如冷凝物的流体时，温度受控的环境与环境环境密封，使得进入或离开外壳的空气流大幅减少或消除。

    COMPOUND SAMPLE NEEDLE FOR LIQUID CHROMATOGRAPH
    75.
    发明申请
    COMPOUND SAMPLE NEEDLE FOR LIQUID CHROMATOGRAPH 审中-公开
    化合物样品用于液相色谱

    公开(公告)号：WO2011085338A1

    公开(公告)日：2011-07-14

    申请号：PCT/US2011/020728

    申请日：2011-01-11

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  AUCLAIR, John ,  USOWICZ, James, E. ,  LIN, Tony, A. ,  LEMELIN, Marc ,  JENCKS, Robert, A. ,  PLANT, Kenneth, R.

    Inventor： AUCLAIR, John ,  USOWICZ, James, E. ,  LIN, Tony, A. ,  LEMELIN, Marc ,  JENCKS, Robert, A. ,  PLANT, Kenneth, R.

    IPC: G01N1/00

    CPC classification number: G01N30/18 ,  B01L3/561 ,  B01L3/563 ,  B01L2200/026 ,  G01N1/10 ,  G01N30/24 ,  G01N30/36 ,  G01N30/6039

    Abstract: Described is a compound sample needle for a liquid chromatography system. In one embodiment, the compound sample needle includes a rigid needle having a coupling end with a face and a counterbore. The compound sample needle also includes a flexible tubing having an outer surface and a coupling end disposed in the counterbore of the rigid needle. The coupling end of the flexible tubing has a face adjacent to a base of the counterbore. The coupling ends of the rigid needle and flexible tubing are secured to each other by a weld formed along a circumference of the outer surface and the face of the rigid needle. A rigid sleeve protects the welded joint. The compound sample needle is suitable for injection into the high pressure mobile phase of ultra performance liquid chromatography systems.

    Abstract translation: 描述了用于液相色谱系统的复合样品针。 在一个实施例中，复合样品针包括刚性针，其具有与面和沉孔的连接端。 复合样品针还包括柔性管，其具有设置在刚性针的沉孔中的外表面和联接端。 柔性管的连接端具有邻近沉孔的底部的面。 刚性针和柔性管的联接端通过沿着外表面的​​圆周和刚性针的表面形成的焊接彼此固定。 刚性套筒保护焊接接头。 复合样品针适用于注射高压流动相超高效液相色谱系统。

    TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY
    76.
    发明申请
    TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY 审中-公开
    色谱条件下分离柱的温度控制

    公开(公告)号：WO2010138678A1

    公开(公告)日：2010-12-02

    申请号：PCT/US2010/036335

    申请日：2010-05-27

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MURPHY, James P. ,  FADGEN, Keith ,  GERHARDT, Geoff C. ,  DONEANU, Angela ,  STAPELS, Martha, Degen

    IPC: B01D35/18 ,  C02F1/02

    CPC classification number: G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

    Abstract: A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.

    Abstract translation: 分析样品的方法包括将足够量的样品加载到陷阱柱上以使捕获柱过载; 将分析柱和捕集柱加热至比分析柱更大的温度; 并将溶剂泵送到捕集塔，其具有溶剂组成分布，其与温差相配合使至少一些组分从捕集塔顺序洗脱至分析柱，并在分离柱之前聚焦在分析柱上 从分析柱洗脱; 或任选地：将小分子样品加载到分析柱的冷却部分上; 加热分析柱; 并将溶剂泵入加热的分析柱，以从分析柱中洗脱组分。 色谱分离包括：陷阱柱; 分离柱; 一个陷阱加热器; 分离柱加热器; 溶剂泵单元; 并且可以使用控制单元。

    LIGHT-GUIDING FLOW CELLS AND ANALYTICAL DEVICES USING THE SAME
    79.
    发明申请
    LIGHT-GUIDING FLOW CELLS AND ANALYTICAL DEVICES USING THE SAME 审中-公开
    光引导细胞和使用该细胞的分析装置

    公开(公告)号：WO2009143217A1

    公开(公告)日：2009-11-26

    申请号：PCT/US2009/044633

    申请日：2009-05-20

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  JEANNOTTE, Anthony ,  LEVEILLE, Michael, J. ,  DENECKE, Frank

    Inventor： JEANNOTTE, Anthony ,  LEVEILLE, Michael, J. ,  DENECKE, Frank

    IPC: G01N1/10

    CPC classification number: G01N21/05 ,  G01N35/1095 ,  G01N2021/0346 ,  G01N2201/024 ,  G01N2201/08 ,  G01N2201/086

    Abstract: A flow cell for a photometric device includes a module having a body with a distal face defining an annular channel. The body also defines an axial central passage and an axial flow channel. A second module has a body with a proximal face defining an annular channel. The second body also defines an axial flow channel in fluid communication with the first axial flow channel. A light guiding member is within the central passage for exposing a fluid in the flow channels of the modules. An assembly seals an interface between the distal and proximal faces such that the fluid does not leak from the flow channels. The assembly has a metal gasket between the distal and proximal faces, the metal gasket defining a flow path between the flow channels, a first sealing member in the first annular channel and a second sealing member in the second annular channel.

    Abstract translation: 用于光度测量装置的流动池包括具有主体的模块，该主体具有限定环形通道的远端面。 主体还限定轴向中心通道和轴向流动通道。 第二模块具有主体，其具有限定环形通道的近端面。 第二主体还限定与第一轴向流动通道流体连通的轴向流动通道。 导光构件在中央通道内部，用于暴露模块的流动通道中的流体。 组件密封远端和近端面之间的界面，使得流体不会从流动通道泄漏。 该组件在远端和近端面之间具有金属垫圈，金属垫圈限定了流动通道之间的流动路径，第一环形通道中的第一密封构件和第二环形通道中的第二密封构件。

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