中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

37 records (took 0.029 seconds)

    APPARATUS AND METHODS FOR CREATING A STATIC AND TRAVERSING THERMAL GRADIENT ON A MICROFLUIDIC DEVICE
    3.
    发明申请
    APPARATUS AND METHODS FOR CREATING A STATIC AND TRAVERSING THERMAL GRADIENT ON A MICROFLUIDIC DEVICE 审中-公开
    用于在微流体装置上形成静态和阻挡热梯度的装置和方法

    公开(公告)号：WO2015020963A1

    公开(公告)日：2015-02-12

    申请号：PCT/US2014/049616

    申请日：2014-08-04

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MICHIENZI, Joseph D. ,  MURPHY, James P. ,  FOGWILL, Michael O. ,  FADGEN, Keith ,  GERHARDT, Geoff ,  BERTONE, Gary W.

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L7/54 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2300/1811 ,  B01L2300/1894

    Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.

    Abstract translation: 用于分离系统的微流体装置包括具有流体通道的基板。 由厚膜材料制成的一个或多个加热器与基板一体化并且与衬底的流体通道热连通。 响应于流过一个或多个加热器的电流，一个或多个加热器在流体通道内产生热梯度。 多个导电抽头可以与一个或多个加热器导电接触。 多个导电抽头提供到一个或多个加热器的导电路径，电源可以通过该导电路径产生流过一个或多个加热器的电流。 或者，厚膜材料可以是铁磁性的，并且电源可以使用感应来使电流流过一个或多个加热器。

    SPRING-ENERGIZED CHECK VALVE
    4.
    发明申请
    SPRING-ENERGIZED CHECK VALVE 审中-公开
    弹簧加压止回阀

    公开(公告)号：WO2018031443A1

    公开(公告)日：2018-02-15

    申请号：PCT/US2017/045687

    申请日：2017-08-07

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MUSACCHIO, Jeffrey ,  MICHIENZI, Joseph D. ,  FADGEN, Keith

    IPC: F16K15/12 ,  F16K1/12 ,  F16K1/46 ,  F16K15/00 ,  F16K15/02 ,  F16K15/10 ,  F16K15/08

    Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

    Abstract translation: 止回阀包括具有腔室的第一阀体，第二阀体和第三阀体位于该腔室中。 止回阀还包括设置在腔室中的弹簧加压密封件。 弹簧加压密封件包括具有环形形状的柔性密封体和设置在密封体的口袋中的弹性构件，诸如带刻度的弹簧或O形环。 弹性构件对密封体的部分施加力，以防止流体从阀入口端口流向阀出口端口，除非差动流体超过止回阀的开启压力。

    TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY
    5.
    发明申请
    TEMPERATURE CONTROL OF ENRICHMENT AND SEPARATION COLUMNS IN CHROMATOGRAPHY 审中-公开
    色谱条件下分离柱的温度控制

    公开(公告)号：WO2010138678A1

    公开(公告)日：2010-12-02

    申请号：PCT/US2010/036335

    申请日：2010-05-27

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： MURPHY, James P. ,  FADGEN, Keith ,  GERHARDT, Geoff C. ,  DONEANU, Angela ,  STAPELS, Martha, Degen

    IPC: B01D35/18 ,  C02F1/02

    CPC classification number: G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

    Abstract: A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.

    Abstract translation: 分析样品的方法包括将足够量的样品加载到陷阱柱上以使捕获柱过载; 将分析柱和捕集柱加热至比分析柱更大的温度; 并将溶剂泵送到捕集塔，其具有溶剂组成分布，其与温差相配合使至少一些组分从捕集塔顺序洗脱至分析柱，并在分离柱之前聚焦在分析柱上 从分析柱洗脱; 或任选地：将小分子样品加载到分析柱的冷却部分上; 加热分析柱; 并将溶剂泵入加热的分析柱，以从分析柱中洗脱组分。 色谱分离包括：陷阱柱; 分离柱; 一个陷阱加热器; 分离柱加热器; 溶剂泵单元; 并且可以使用控制单元。

    METHOD AND APPARATUS FOR PERFORMING MASS SPECTROMETRY
    7.
    发明申请
    METHOD AND APPARATUS FOR PERFORMING MASS SPECTROMETRY 审中-公开
    用于执行质谱分析的方法和装置

    公开(公告)号：WO2011014372A1

    公开(公告)日：2011-02-03

    申请号：PCT/US2010/042241

    申请日：2010-07-16

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  FADGEN, Keith

    Inventor： FADGEN, Keith

    IPC: G01N30/72

    CPC classification number: C12M45/09 ,  G01N30/06 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/067 ,  G01N2030/8831 ,  G01N2030/8881

    Abstract: The invention feature devices and methods for preserving and processing samples comprising a fluid having deuterated compounds. The device of the present invention comprises a housing defining a first chamber and a second chamber. The first chamber is heated to an elevated temperature and receives the sample and performs a digestion process on the sample at the elevated temperature. The second chamber is cooled to a low temperature and receives the deuterated digested sample from the first chamber and performs one or more separation steps to isolate an analyte. The device of further comprises conduit means for containing and moving the sample into the first chamber to form a digested sample. The conduit means moves the digested sample from the first chamber to the second chamber to separate the sample to form at least one analyte. The analyte is maintained at the low temperature to preserve its deuterated form.

    Abstract translation: 本发明的特征在于用于保存和处理包含具有氘代化合物的流体的样品的装置和方法。 本发明的装置包括限定第一室和第二室的壳体。 将第一室加热到升高的温度并接收样品并在高温下对样品进行消化处理。 将第二室冷却至低温，并从第一室接收氘代消化的样品，并执行一个或多个分离步骤以分离分析物。 该装置还包括用于容纳和移动样品进入第一室以形成消化样品的导管装置。 导管装置将消化的样品从第一室移动到第二室以分离样品以形成至少一种分析物。 分析物保持在低温以保持其氘化形式。

    LIQUID-CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH-PRESSURE SEALS
    8.
    发明申请
    LIQUID-CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH-PRESSURE SEALS 审中-公开
    具有高压密封的液相色谱仪组件

    公开(公告)号：WO2009088663A1

    公开(公告)日：2009-07-16

    申请号：PCT/US2008/086944

    申请日：2008-12-16

    Applicant: WATERS TECHNOLOGIES CORPORATION ,  BENEVIDES, Christopher, C. ,  FADGEN, Keith ,  LAVALLE, Michael ,  JEANNOTTE, Anthony

    Inventor： BENEVIDES, Christopher, C. ,  FADGEN, Keith ,  LAVALLE, Michael ,  JEANNOTTE, Anthony

    IPC: B01D15/08

    CPC classification number: B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

    Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

    Abstract translation: 制备液相色谱装置的方法包括将两个内导管插入中间管中，将中间管插入外管中，在中间管与至少一个内导管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。

Patent Agency Ranking