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1.发明申请
公开(公告)号：WO2010138678A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036335
申请日：2010-05-27
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： MURPHY, James P. , FADGEN, Keith , GERHARDT, Geoff C. , DONEANU, Angela , STAPELS, Martha, Degen
CPC classification number: G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
Abstract: A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.
Abstract translation: 分析样品的方法包括将足够量的样品加载到陷阱柱上以使捕获柱过载; 将分析柱和捕集柱加热至比分析柱更大的温度; 并将溶剂泵送到捕集塔，其具有溶剂组成分布，其与温差相配合使至少一些组分从捕集塔顺序洗脱至分析柱，并在分离柱之前聚焦在分析柱上 从分析柱洗脱; 或任选地：将小分子样品加载到分析柱的冷却部分上; 加热分析柱; 并将溶剂泵入加热的分析柱，以从分析柱中洗脱组分。 色谱分离包括：陷阱柱; 分离柱; 一个陷阱加热器; 分离柱加热器; 溶剂泵单元; 并且可以使用控制单元。
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公开(公告)号：WO2019224702A2
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge. The cartridge incudes a barrel with a first and second end, a column segment connected to the second end of the barrel, and a column containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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3.发明申请THERMAL-BASED FLOW SENSING APPARATUSES AND METHODS FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 审中-公开基于热流感测装置的高性能液相色谱法
公开(公告)号：WO2011075570A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060734
申请日：2010-12-16
Applicant: WATERS TECHNOLOGIES CORPORATION , GERHARDT, Geoff C.
Inventor： GERHARDT, Geoff C.
CPC classification number: G01N30/32 , G01F1/00 , G01F1/6845 , G01N11/00 , G01N2030/324
Abstract: One aspect of the invention provides a flow sensing apparatus including: a fluid channel that allows a fluid to flow in a first direction; a first thermoelectric sensing element arranged at a first position along the fluid channel such that it senses a temperature of the fluid; a second thermoelectric sensing element arranged at a second position along the fluid channel and separated from the first sensing element by a predetermined distance along the fluid channel; and a heating element arranged between the first and second thermoelectric sensing elements, the heating element being equally spaced from the first and second thermoelectric sensing elements.
Abstract translation: 本发明的一个方面提供了一种流量检测装置，包括：允许流体沿第一方向流动的流体通道; 布置在沿着流体通道的第一位置处的第一热电传感元件，使得其感测流体的温度; 第二热电感测元件，布置在沿着流体通道的第二位置处，并沿着流体通道与第一感测元件分开预定距离; 以及加热元件，其布置在所述第一和第二热电感测元件之间，所述加热元件与所述第一和第二热电感测元件等间隔开。
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公开(公告)号：WO2019224702A3
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054162
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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5.发明申请
公开(公告)号：WO2019224701A1
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054161
申请日：2019-05-20
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： GILAR, Martin , MCDONALD, Thomas S. , MICHIENZI, Joseph D. , MUSACCHIO, Jeffrey , MUMMA, Rachel , FADGEN, Keith , GERHARDT, Geoff C.
Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
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Patent Agency Ranking
公开(公告)号：WO2019073442A1
公开(公告)日：2019-04-18
申请号：PCT/IB2018/057905
申请日：2018-10-11
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： FOGWILL, Michael O. , MURPHY, James P. , GERHARDT, Geoff C.
CPC classification number: B01D53/025 , B01D15/163 , B01D15/40 , G01N30/32 , G01N30/6095 , G01N30/8658
Abstract: The present disclosure relates to a method of configuring a chromatography system (500) whereby a separation column (515) having an operative flow rate is matched to an appropriate restrictor (521), which is capable of maintaining the post-column pressure at a target pressure. A kit comprising the matched column-restrictor pair and a processing unit is disclosed as is an integrated microfluidic chromatography system comprising such a matched column-restrictor pair.
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7.发明公开
公开(公告)号：EP2435158A1
公开(公告)日：2012-04-04
申请号：EP10781189.5
申请日：2010-05-27
Applicant: Waters Technologies Corporation
Inventor： MURPHY, James P. , FADGEN, Keith , GERHARDT, Geoff C. , DONEANU, Angela , STAPELS, Martha, Degen
CPC classification number: G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
Abstract: A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.
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公开(公告)号：EP2044352A2
公开(公告)日：2009-04-08
申请号：EP07799797.1
申请日：2007-07-25
Applicant: Waters Technologies Corporation
Inventor： CHARLTON, Christopher B. , GERHARDT, Geoff C. , DOURDEVILLE, Theodore
CPC classification number: F16K15/021 , F04B53/1032 , Y10T137/7837 , Y10T137/7876 , Y10T137/7922 , Y10T137/7925
Abstract: A check valve includes a valve seat and a compliant member that moves to seal the check valve by contacting the valve seat. A method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an outlet of the pump, drawing fluid into the pump from a fluid source, and expelling the fluid from the pump through the valve, thus wetting the check valve. Another method for priming a chromatography solvent pump includes providing the check valve in fluid communication with an inlet of the pump, drawing fluid through the valve into the pump, and expelling the fluid from the pump.
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公开(公告)号：EP3797291A2
公开(公告)日：2021-03-31
申请号：EP19744841.8
申请日：2019-05-20
Applicant: Waters Technologies Corporation
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10.发明公开
公开(公告)号：EP3797278A1
公开(公告)日：2021-03-31
申请号：EP19737214.7
申请日：2019-05-20
Applicant: Waters Technologies Corporation
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