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    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS
    72.
    发明申请
    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS 审中-公开
    流体结构包括测量和宽频道

    公开(公告)号：WO2006113727A3

    公开(公告)日：2007-02-15

    申请号：PCT/US2006014583

    申请日：2006-04-19

    Applicant: HARVARD COLLEGE ,  LINDER VINCENT ,  SIA SAMUEL K ,  WHITESIDES GEORGE M ,  NAROVLYANSKY MAX ,  SIEGEL ADAM

    Inventor： LINDER VINCENT ,  SIA SAMUEL K ,  WHITESIDES GEORGE M ,  NAROVLYANSKY MAX ,  SIEGEL ADAM

    IPC: G01N21/59 ,  B01L3/00 ,  G01N33/543 ,  G01N33/553

    CPC classification number: G01N33/54366 ,  B01L3/502746 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0406 ,  G01N21/01 ,  G01N21/82 ,  G01N33/54373

    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    Abstract translation: 本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。 微流控系统可以提供用于执行各种反应和分析的有利环境，这是由于与常规系统相比所需的样品和试剂量的减少，操作系统尺寸的减小以及反应时间的减少。 不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。 一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。 尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

    MICROFLUIDIC LASERS
    73.
    发明申请
    MICROFLUIDIC LASERS 审中-公开

    公开(公告)号：WO2006086551A3

    公开(公告)日：2006-08-17

    申请号：PCT/US2006/004577

    申请日：2006-02-08

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  MAYERS, Brian, T. ,  CONROY, Richard, S. ,  VEZENOV, Dmitri, V. ,  SNEE, Preston ,  CHAN, Yinthai ,  BAWENDI, Moungi, G. ,  WHITESIDES, George, M.

    Inventor： MAYERS, Brian, T. ,  CONROY, Richard, S. ,  VEZENOV, Dmitri, V. ,  SNEE, Preston ,  CHAN, Yinthai ,  BAWENDI, Moungi, G. ,  WHITESIDES, George, M.

    IPC: H01S3/05 ,  H01S3/20 ,  H01S3/213

    Abstract: The present invention generally relates to lasers comprising fluidic channels, such as microfluidic channels. In some instances, the channel contains two or more fluids. The fluids may remain non-mixed within the channel, for example, due to immiscibility and/or laminar flow within the channel. The fluids may be arranged in the channel such that light propagating in a first fluid is prevented by the second fluid from exiting the first fluid, for example, due to differences in the indexes of refraction (e.g., causing internal reflection of the fluid to occur). Thus, in one embodiment, a first fluid may be at least partially surrounded by a second fluid having a second index of refraction lower than the index of refraction of the first fluid. In some embodiments, the fluidic channel is used as a laser, for instance, a dye laser, i.e., a laser created by directing light at a dye to produce coherent light. The dye may be present in one or more fluids within the fluidic channel. The incident light (for example, created by another laser) may be directed at the channel from any angle. In some cases, laser light may be produced in a direction substantially aligned with the longitudinal axis of the channel. In some embodiments, the laser is free of mirrors, prisms, or gratings, or the laser may produce coherent light using a non-resonant photonic pathway. However, in other cases, mirrors, prisms, or gratings may be used to reflect light along the channel to enhance stimulated emission of coherent light. Another aspect of the invention includes optical diffractors, such as prisms or gratings, which can contain a fluid. The optical diffractors, in certain embodiments, are positioned to diffract light, such as coherent light, emanating from the fluidic channel. Still other aspects of the invention provide devices, kits, and methods of making and using such lasers.

    ASSAY DEVICE AND METHOD
    75.
    发明申请
    ASSAY DEVICE AND METHOD 审中-公开
    测定装置和方法

    公开(公告)号：WO2005066613A1

    公开(公告)日：2005-07-21

    申请号：PCT/US2004/043585

    申请日：2004-12-29

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  SIA, Samuel, K. ,  LINDER, Vincent ,  PARVIZ, Babak, A. ,  SIEGEL, Adam ,  WHITESIDES, George, M.

    Inventor： SIA, Samuel, K. ,  LINDER, Vincent ,  PARVIZ, Babak, A. ,  SIEGEL, Adam ,  WHITESIDES, George, M.

    IPC: G01N21/53

    CPC classification number: G01N33/56988 ,  B01L3/502707 ,  B01L2300/0822 ,  B01L2300/168 ,  G01N21/05 ,  G01N21/59 ,  G01N33/5302 ,  G01N33/543 ,  G01N33/585 ,  G01N2021/0346 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339

    Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

    Abstract translation: 描述了测定方法，其包括以下步骤：将待检测分析物（例如，抗体或抗原）的结合配偶体（例如，抗原或抗体）固定在表面（130）的部分（140）上 微流体室（120,122,124）; 将流体样品通过表面并允许分析物结合到结合配偶体; 允许金属胶体，例如金共轭抗体与结合的分析物缔合; 在表面上流动金属溶液，例如银溶液，以形成不透明的金属层; 并且例如通过目视检查或通过在将金属溶液流过表面之后测量金属溶液中的层的透光率，层的导电性或电阻或金属浓度来检测所述金属层的存在。

    ALTERATION OF SURFACE AFFINITIES
    77.
    发明申请
    ALTERATION OF SURFACE AFFINITIES 审中-公开
    表面附着力的改变

    公开(公告)号：WO2004067191A2

    公开(公告)日：2004-08-12

    申请号：PCT/US2004/002498

    申请日：2004-01-29

    Applicant: PRESIDENT AND FELLOWS OF HARWARD COLLEGE ,  JIANG, Xingyu ,  FERRIGNO, Rosaria ,  WHITESIDES, George, M.

    Inventor： JIANG, Xingyu ,  FERRIGNO, Rosaria ,  WHITESIDES, George, M.

    IPC: B05D3/14

    CPC classification number: B82Y30/00 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3225 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3274 ,  B01J20/3285 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B05D3/14 ,  B05D3/207 ,  G01N33/54353 ,  G01N2610/00 ,  Y10S436/823 ,  Y10T436/118339

    Abstract: The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.

    Abstract translation: 本发明提供了用于通过暴露至少一部分表面来改变表面性质（例如亲细胞性和/或亲水性）的一系列方法，组合物和制品 到非化学的，产生力的场和/或力，例如电场。 场/力可以通过任何合适的技术来创建。 例如，可以通过在表面上施加电压，通过电感应等来产生场。在某些实施方案中，表面包括附着于其上的分子，当暴露于非化学力产生场时可以将其分离，和/或 从而改变至少一部分表面的化学组成。 在一组实施方案中，附着于表面的分子可以包括在表面上形成自组装单层的分子。 在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在烷硫醇中），通过该硫醇部分该分子可以附着到表面。 在某些情况下，分子可以在一个或多个亲水基团（例如未改性的乙二醇部分）的未连接末端处终止。 在一些情况下，附着于表面的分子可以包括一个或多个可结合各种实体的部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，所述技术用于实现用于 细胞运动性和/或扩散和筛选测试以确定有效增加或减少细胞形状变化和/或表面运动性的药物和/或治疗。

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