公开(公告)号：CA2129367C

公开(公告)日：2000-12-05

申请号：CA2129367

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  RAYMOURE WILLIAM J

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/546

Abstract: 2129367 9320444 PCTABS00027 A method for modifying a liquid assay reagent to provide prolonged homogeneity thereof, particularly where the liquid assay reagent comprises microparticles for performing a heterogeneous immunoassay, is provided wherein the addition of an inert material to a liquid assay reagent achieves neutral density to thereby prolong the homogeneity thereof for extended periods of time. A method for the automated agitation of assay reagents to maintain the homogeneity thereof with an automated, continuous and random access analytical instrument is also provided. The automated mixing is accomplished by a back and forth motion of a carousel onto which assay reagent containers or packs are mounted with asymmetric pauses which can be completed within a short period of time. The carousel acceleration, velocity, distance moved, and pause-asymmetry are optimized to provide rapid assay reagent resuspension without foaming or bubble formation. Accordingly, periodic removal of assay reagent packs by an operator in order to mix the reagents is not necessary.

公开(公告)号：CA2362531A1

公开(公告)日：1995-03-30

申请号：CA2362531

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： KANEWSKE WILLIAM J III ,  VICKSTROM RICHARD L ,  CLIFT GILBERT ,  CLEMENS JOHN M ,  WATKINS WILLIAM E III ,  SMITH B JANE ,  WALKER EDNA S ,  TAYI APPARAO ,  HENDRICK KENDALL B ,  CLARK FREDERICK L ,  WALKER DONNY RAY ,  STANTON ALYN K ,  MITCHELL JAMES E ,  CLOONAN KEVIN M ,  SPRONK ADRIAN M ,  HANCE ROBERT B ,  YOST DAVID A ,  HILLS DAVID B ,  LAGOCKI PETER A ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  WINTER GARY E ,  OLEKSAK CARL M ,  RAYMOURE WILLIAM J ,  PENNINGTON CHARLES D ,  RUMBAUGH WILLIAM D ,  WOHLFORD ROBERT A ,  VAUGHT JAMES A ,  MCDOWELL DOUGLAS D ,  MARTIN RICHARD R

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：AU3968093A

公开(公告)日：1993-11-08

申请号：AU3968093

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  KANEWSKE WILLIAM J III

IPC: G01N21/64 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  G01N1/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/49 ,  G01N21/59 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N35/06

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：AU3967793A

公开(公告)日：1993-11-08

申请号：AU3967793

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： RAYMOURE WILLIAM J ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/546

公开(公告)号：CA2512707A1

公开(公告)日：1993-10-14

申请号：CA2512707

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： LAGOCKI PETER A ,  MARTIN RICHARD R ,  STANTON ALYN K ,  VICKSTROM RICHARD L ,  WATKINS WILLIAM E III ,  KANEWSKE WILLIAM J III ,  OLEKSAK CARL M ,  CLARK FREDERIC L ,  WINTER GARY E ,  SCHRIER PAUL R ,  HILLS DAVID B JR ,  VAUGHT JAMES A ,  CLIFT GILBERT ,  TAYI APPARAO ,  SMITH B JANE ,  YOST DAVID A ,  WOHLFORD ROBERT A ,  HENDRICK KENDALL B ,  PENNINGTON CHARLES D ,  RUMBAUGH WILLIAM ,  MOORE LARRY W ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  WALKER EDNA S ,  HANCE ROBERT B

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/00 ,  H01J49/04 ,  H02P8/00 ,  H05B41/00

公开(公告)号：CA2129368A1

公开(公告)日：1993-10-14

申请号：CA2129368

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： SCHMIDT LINDA S ,  SPRONK ADRIAN M ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MITCHELL JAMES E ,  MARTIN RICHARD R ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: 2129368 9320443 PCTABS00027 A method for verifying that an assay methodology is properly performed that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.