公开(公告)号：AU2012205486B2

公开(公告)日：2017-02-02

申请号：AU2012205486

申请日：2012-01-12

Applicant: ARRAY BIOPHARMA INC ,  VENTIRX PHARMACEUTICALS INC

Inventor： HOWBERT JAMES JEFFRY ,  HERSHBERG ROBERT ,  BURGESS LAURENCE E ,  YANG HONG WOON

IPC: C07D223/16 ,  A61K31/55 ,  A61P29/00 ,  A61P35/00 ,  C07D403/10

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

公开(公告)号：CA2969709A1

公开(公告)日：2016-06-09

申请号：CA2969709

申请日：2015-12-04

Applicant: ARRAY BIOPHARMA INC ,  CELGENE CORP

Inventor： ALLEN SHELLEY ,  BOYS MARK LAURENCE ,  CHICARELLI MARK J ,  FELL JAY BRADFORD ,  FISCHER JOHN P ,  GAUDINO JOHN ,  HICKEN ERIK JAMES ,  HINKLIN RONALD JAY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  ROBINSON JOHN E ,  TANG TONY P ,  BURGESS LAURENCE E ,  RIEGER ROBERT ANDREW ,  PHENEGER JED ,  SATOH YOSHITAKA ,  LEFTHERIS KATERINA ,  RAHEJA RAJ K ,  BENNETT BRYDON L

IPC: C07D487/04 ,  A61K31/4985 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：AU2011240808B2

公开(公告)日：2015-01-22

申请号：AU2011240808

申请日：2011-04-11

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  GRONEBERG ROBERT D ,  HARVEY DARREN M ,  HUANG LILY ,  KERCHER TIMOTHY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  TARLTON EUGENE ,  ZHAO QIAN

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R

公开(公告)号：SG2014013528A

公开(公告)日：2014-07-30

申请号：SG2014013528

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： CLARK CHRISTOPHER T ,  COOK ADAM ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  ROMOFF TODD ,  GANGHYEOK KIM ,  BURGESS LAURENCE E

Abstract: A compound which is 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)-phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof. Said compound is either a racemic mixture or a single enantiomer, preferably Enantiomer 2 of 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof, in particular its sodium salt. Said compound for use in treating an immunologic disorder in a mammal.

公开(公告)号：CR20120572A

公开(公告)日：2013-02-20

申请号：CR20120572

申请日：2012-11-09

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  GRONEBERG ROBERT D ,  HARVEY DARREN M ,  HUANG LILY ,  KERCHER TIMOTHY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  TARLTON EUGENE ,  ZHAO QIAN

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

Abstract: Los compuestos de la Fórmula I y estereoisómeros y sales y solvatos de los mismos farmacéuticamente aceptables en los cuales R1, R2, R3, R4, R5, R6, R7, X1 y X2 tienen los significados dados en la especificación, son inhibidores de una o más cinasas JAK y son útiles en el tratamiento de enfermedades autoinmunitarias, enfermedades inflamatorias, rechazo de órganos, tejidos y células transplantados, así como también trastornos hematológicos y malignidades y sus co-morbilidades.

公开(公告)号：RS52298B

公开(公告)日：2012-12-31

申请号：RSP20120119

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC

Inventor： LAIRD ELLEN ,  GRONEBERG ROBERT ,  BURGESS LAURENCE E ,  HARVEY DARREN ,  MUNSON MARK ,  RIZZI JAMES ,  EARY CHARLES TODD ,  WATSON DANIEL ,  RODRIGUEZ MARTHA

IPC: C07D231/40 ,  A61K31/416 ,  A61P29/00 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：SG184870A1

公开(公告)日：2012-11-29

申请号：SG2012076493

申请日：2011-04-11

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  GRONEBERG ROBERT D ,  HARVEY DARREN M ,  HUANG LILY ,  KERCHER TIMOTHY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  TARLTON EUGENE ,  ZHAO QIAN

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：CO6362002A2

公开(公告)日：2012-01-20

申请号：CO11010027

申请日：2011-01-28

Applicant: ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  ROMOFF TODD ,  KIM GANGHYEOK ,  HUNT KEVIN W ,  DOHERTY GEORGE ,  DELISLE ROBERT KIRK ,  CORRETTE CHRISTOPHER ,  COOK ADAM

IPC: C07D311/04

Abstract: Compuestos de la Fórmula Ien donde A1, A2, W, L, G, R7a, R7b, R8, R9 y R10 tienen las definiciones que se dieron en la memoria descriptiva, son moduladores de receptor de DP2 que son útiles en el tratamiento de enfermedades inmunológicas.

公开(公告)号：CA2796388A1

公开(公告)日：2011-10-20

申请号：CA2796388

申请日：2011-04-11

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  GRONEBERG ROBERT D ,  HARVEY DARREN M ,  HUANG LILY ,  KERCHER TIMOTHY ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  TARLTON EUGENE ,  ZHAO QIAN

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：AU2007210073B2

公开(公告)日：2011-10-06

申请号：AU2007210073

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC

Inventor： MARTHA RODRIGUEZ ,  BURGESS LAURENCE E ,  MARK MUNSON ,  ELLEN LAIRD ,  ROBERT GRONEBERG ,  TODD EARY CHARLES ,  JAMES RIZZI ,  DANIEL WATSON ,  DARREN HARVEY

IPC: C07D231/40 ,  A61K31/416 ,  A61P29/00 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.