公开(公告)号：DE19735682A1

公开(公告)日：1999-02-25

申请号：DE19735682

申请日：1997-08-19

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  WOERZ OTTO DR ,  FRETSCHNER ERICH ,  HANSEN HANSPETER DR ,  MUELLER ALBRECHT DR ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: Production of 3-isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide (I) from anthranilic acid isopropylamide (II) in a single step is claimed. Production of the benzothiadiazinone-dioxide of formula (I) comprises reacting anthranilic acid isopropylamide of formula (II) simultaneously with (a) sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with adducts of SO3 and organic base; and (b) phosphorus oxychloride. The reaction is carried out at from 50 deg C to the reflux temperature, and the (I) produced is optionally converted to its salt.

公开(公告)号：CA2301194A1

公开(公告)日：1999-02-25

申请号：CA2301194

申请日：1998-07-25

Applicant: BASF AG

Inventor： FRETSCHNER ERICH ,  HANSEN HANSPETER ,  WORZ OTTO ,  MULLER ALBRECHT ,  BENZ KURT ,  MERKLE HANS RUPERT

IPC: C07D285/24 ,  C07D285/16

Abstract: The invention relates to a method for the production of 3-isopropyl-1H-2,1,3-benzothiazine-4(3H)-one-2,2-dioxide (I) or its salt. The method is characterized in that anthranilic acid isopropylamide (II) is reacted simultaneously with sulphur trioxide or chlorosulphonic acid in the presence of an organic base, or with sulphur trioxide adducts on organic bases, and phosphoroxychloride at 50 ~C until reflux temperature, and then optionally transformed into their salts.

公开(公告)号：AU702286B2

公开(公告)日：1999-02-18

申请号：AU6738096

申请日：1996-07-26

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12

Abstract: PCT No. PCT/EP96/03316 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 26, 1996 PCT Pub. No. WO97/06148 PCT Pub. Date Feb. 20, 1997A process for the preparation of 1,2-dimethyl-3,5-diaryl-pyrazolium methylsulfates of the formula I I where R1 and R2 independently of one another are hydrogen, C1-C4-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, halogen, nitro, C1-C4-haloalkyl or aryl all of which are inert under the reaction conditions, in which 1-methyl-3,5-diarylpyrazoles of the formula II II where R1 and R2 have the abovementioned meanings are reacted with a) methanol and SO3, b) methanol and sulfuric acid or optionally, c) methanol and methylsulfuric acid elevated temperatures.

公开(公告)号：AU9141998A

公开(公告)日：1999-01-04

申请号：AU9141998

申请日：1998-06-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12 ,  C07D20060101 ,  C07D231/10

Abstract: Pyrazole derivatives are prepared by reacting carbonyl compounds R1-C(O)-CH(R2)-CH2R3 with hydrazine, its hydrate or its salts in 30 to 100% by weight sulfuric acid in the presence of catalytic amounts of iodine or of an iodine compound.

公开(公告)号：IN181950B

公开(公告)日：1998-11-14

申请号：IN1379MA1996

申请日：1996-08-05

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/00 ,  C07C139/00

公开(公告)号：BR9607649A

公开(公告)日：1998-06-16

申请号：BR9607649

申请日：1996-02-27

Applicant: BASF AG

Inventor： FRETSCHNER ERICH ,  MERKLE HANS RUPERT ,  SCHRODER JURGEN

IPC: C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP96/00790 Sec. 371 Date Aug. 20, 1997 Sec. 102(e) Date Aug. 20, 1997 PCT Filed Feb. 27, 1996 PCT Pub. No. WO96/27589 PCT Pub. Date Sep. 12, 1996A process for the preparation of an N-alkyl- or N-phenylalkyl-substituted pyrazole I by reacting the corresponding N-unsubstituted pyrazole II with an alcohol III of the formula R1-OH where R1 is the same alkyl or phenylalkyl group to be added to the unsubstituted nitrogen group -NH- of the pyrazole reactant. Both of the reactants, i.e. the pyrazole II and alcohol III compounds, are catalytically reacted in the liquid phase in a molar ratio of from 0.001:1 to 1:1, at temperatures of 50 DEG -400 DEG C. and under a subatmosheric pressure of from 0.8 bar up to a superatmospheric pressure of 250 bar. The catalyst required for this liquid phase reaction is selected as being at least one or more non-heterogeneous acid catalysts, their alkyl esters or their acid anhydrides.

公开(公告)号：BG101908A

公开(公告)日：1998-05-29

申请号：BG10190897

申请日：1997-09-24

Applicant: BASF AG

Inventor： MERKELE HANS R ,  FRETSCHNER ERICH ,  SCHROEDER JUERGEN

IPC: C07D231/12 ,  C07D521/00

Abstract: A process is disclosed for preparing N-substituted pyrazoleshaving the general formulain which R1 stands for C1 to C12 alkyl or C7 to C20 phenylalkyl,and R2, R3, R4 represent independently from each other hydrogen,C1 to C12 alkyl, C7 to C20 phenylalkyl or optionally substitutedaryl residues, by reacting pyrazoles having the general formulain which R2, R3 and R4 have above-said meanings, with an alcoholhaving the general formulaR1-O-H, in which R1 has above-said meanings, at temperatures from50 to 400oC in the presence of a catalyst. The reaction ofpyrazole (II) with compound (III) is carried out in a molar ratiofrom 0.001:1 to 1: 1 in the liquid phase at a slight negativepressure up to an over pressure of 250 bars. Acids. their alkylesters and/or their anhydrides are used as catalysts in a molarratio from 0.0001: 1 to 0.5: 1 in relation to pyrazole (II).10 claims

公开(公告)号：DE59405805D1

公开(公告)日：1998-05-28

申请号：DE59405805

申请日：1994-08-13

Applicant: BASF AG

Inventor： MERKLE HANS ,  FRETSCHNER ERICH

IPC: C07B35/04 ,  C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP94/02708 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 13, 1994 PCT Pub. No. WO95/06036 PCT Pub. Date Mar. 2, 1995A process for preparing pyrazole and its derivatives of the formula I I where R1, R2, R3 and R4 are each hydrogen, halogen, nitro, carboxyl, sulfonyl or C-organic radicals, from alpha,beta-unsaturated carbonyl compounds of the formula II II and hydrazine or hydrazine derivatives of the formula III H2N-NHR4 III wherein, initially without additional diluent, an alpha,beta-unsaturated carbonyl compound of the formula II is reacted with hydrazine or a hydrazine derivative of the formula III, and the resulting reaction mixture is reacted in another step with a mixture of sulfuric acid and iodine or a compound which liberates iodine or hydrogen iodide.

公开(公告)号：PL320943A1

公开(公告)日：1997-11-24

申请号：PL32094395

申请日：1995-12-13

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  BRENNER KARL SIEGFRIED ,  FRETSCHNER ERICH ,  SCHOENHERR MICHAEL ,  VAN GASTEL ANNE

IPC: A01N39/02 ,  A01N39/04 ,  C07C51/41 ,  C07C59/68 ,  C07C59/70

Abstract: PCT No. PCT/EP95/04934 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 13, 1995 PCT Pub. No. WO96/20155 PCT Pub. Date Jul. 4, 1996Process for preparing solid, free-flowing water-soluble salts of aryloxy-C1-C4-alkanecarboxylic acids by reacting the aryloxy-C1-C4-alkanecarboxylic acids with a salt-forming base, the salt formation taking place in the melt in the presence or absence of an entraining agent suitable for the azeotropic removal of water or in solution in the presence of an entraining agent suitable for the azeotropic removal of water and, if appropriate, removing the entraining agent from the reaction mixture during the reaction or subsequently and then isolating the solid salts in a customary manner.

公开(公告)号：CA2223973A1

公开(公告)日：1997-02-20

申请号：CA2223973

申请日：1996-07-26

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12

Abstract: The invention concerns a method of preparing 1,2-dimethyl-3,5-diarylpyrazolium methylsulphates of general formula (I) in which R1 and R2, independently of each other, may be hydrogen, C1-C4 alkyl, C3-C8 cycloalkyl, C1-C4 alkoxy, halogen, nitro C1-C4 haloalkyl, aryl or other substituents which are inert under the conditions of the reaction. The method calls for 1-methyl-3,5-diarylpyrazoles of general formula (II), in which R1 and R2 are as defined above, to be reacted at elevated temperatures with a) methanol and SO3, b) methanol and sulphuric acid and/or c) methanol and methylsulphuric acid.