POLYVINYL ACETATE FILM COATINGS WITH CONTROLLED RELEASE AND HIGH STABILITY

    公开(公告)号:CA2478407C

    公开(公告)日:2010-10-19

    申请号:CA2478407

    申请日:2003-03-11

    Applicant: BASF AG

    Abstract: The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which agents are released in a controlled manner, and methods for the production thereof. The controlled-release properties can be specifically adjusted by means of said combinations, resulting in films having excellent mechanical stability and storage stability. In particular, agents are released independent of the pH by means of the inventive forms of administration.

    RECUBRIMIENTOS DE PELICULA CON LIBERACION CONTROLADA Y ALTA ESTABILIDAD.

    公开(公告)号:ES2288600T3

    公开(公告)日:2008-01-16

    申请号:ES03711965

    申请日:2003-03-11

    Applicant: BASF AG

    Abstract: Una forma de dosis que contiene ingrediente activo que se suministra con un recubrimiento de película y tiene una liberación controlada independiente de pH, que comprende sustancias medicinales, sustancias medicinales veterinarias, vitaminas, caroteniodes, nutraceúticos, suplementos alimenticios o aditivos, minerales, elementos en trazas o ingredientes activos, donde el recubrimiento de la película tiene un grosor de entre 20 y 200 Pm y comprende (A) 10 - 99% en peso de acetato de polivinilo, (B) 1 - 50% en peso de al menos un polímero seleccionado del grupo que consiste de polímeros insolubles en agua lipofílicos, polímeros insolubles en ácido y polímeros insolubles en álcali, y (C) 0 - 50% en peso de otras ayudas farmacéuticamente aceptables, y el total de los componentes (A), (B) y (C) es 100% en peso y donde la proporción de (A) a (B) es de 70:30 a 99:1.

    78.
    发明专利
    未知

    公开(公告)号:DE102005042039A1

    公开(公告)日:2007-03-08

    申请号:DE102005042039

    申请日:2005-09-02

    Applicant: BASF AG

    Abstract: Processes comprising: providing a monomer composition comprising a vinyl acetate monomer component and second monomer component comprising an additional monomer selected from the group consisting of acrylic acid, methacrylic acid and mixtures thereof in an amount of 0.05 to 5% by weight, wherein the vinyl acetate monomer component and the second monomer component comprise 100% by weight of the monomer composition; and free-radically polymerizing the monomer composition in the presence of 0.001 to 1% by weight of an ionic emulsifier, based on the weight of the monomer composition, to form an aqueous polymer dispersion; polymer dispersions and powders prepared therewith; and uses of such dispersions and powders in pharmaceuticals and/or cosmetics.

    79.
    发明专利
    未知

    公开(公告)号:DE102005026755A1

    公开(公告)日:2006-12-14

    申请号:DE102005026755

    申请日:2005-06-09

    Applicant: BASF AG

    Abstract: A process for producing solid solutions in powder or granule form of slightly soluble substances in which the slightly soluble substance is in the form of a molecular dispersion in an excipient matrix, by atomizing a solution of the active ingredient and of the matrix excipients, which comprises heating an aqueous suspension of the slightly soluble substance in the presence of the matrix excipients to temperatures above the boiling point under atmospheric pressure, and dissolving the slightly soluble substance, and subsequently converting the solution of the slightly soluble substance and of the matrix excipients by atomizing and drying into a solid form, where the temperature of the spray solution before feeding into the atomizing apparatus is 90° C. to 350° C.

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