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公开(公告)号：ES2151741T3
公开(公告)日：2001-01-01
申请号：ES97934552
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：ES2143666T3
公开(公告)日：2000-05-16
申请号：ES95941015
申请日：1995-11-25
Applicant: BASF AG
Inventor： BOHM HANS JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOFFKEN HANS WOLFGANG
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公开(公告)号：AU717692B2
公开(公告)日：2000-03-30
申请号：AU3771597
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：NZ302649A
公开(公告)日：2000-01-28
申请号：NZ30264996
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , HOFFKEN HAN WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: he present invention relates to carbo- and heterocyclic amidines, the preparation thereof and the use as thrombin inhibitors of the formula 1 Where D is formula 1a R2 is H, C1-4 alkyl, phenyl and phenyl C1-4 alkyl, R18O-CH2, R18CO- R18-O-CH2-CO-, R18O-CO-CO-, R18-NH-CO-CO, where R18 is H or C1-4-alkyl, CF3-CO- or C2F5-Co- A is formula IIa, IIb or Iic B is selected from IIIa-IIIg The other substituents are defined in the specification.
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公开(公告)号：CZ21099A3
公开(公告)日：2000-01-12
申请号：CZ21099
申请日：1997-07-14
Applicant: BASF AG
Inventor： MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , BALKENHOHL FRIEDHELM , LANGE UDO
IPC: C07D207/22
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Patent Agency Ranking
公开(公告)号：AU708001B2
公开(公告)日：1999-07-29
申请号：AU4875196
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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公开(公告)号：HU9800634A2
公开(公告)日：1999-06-28
申请号：HU9800634
申请日：1996-02-06
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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公开(公告)号：AU706834B2
公开(公告)日：1999-06-24
申请号：AU4787596
申请日：1996-02-06
Applicant: BASF AG
Inventor： SEITZ WERNER , MACK HELMUT , ZIERKE THOMAS , BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , KOSER STEFAN , PFEIFFER THOMAS , HORNBERGER WILFRIED
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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公开(公告)号：ZA9706637B
公开(公告)日：1999-01-25
申请号：ZA9706637
申请日：1997-07-25
Applicant: BASF AG
Inventor： MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , BALKENHOHL FRIEDHELM , LANGE UDO
IPC: C12P17/04 , C07D207/22 , C07D401/12 , C07D , C07B
CPC classification number: C07D207/22
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公开(公告)号：AU699501B2
公开(公告)日：1998-12-03
申请号：AU2787595
申请日：1995-06-06
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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