公开(公告)号：WO1992001483A1

公开(公告)日：1992-02-06

申请号：PCT/US1991004966

申请日：1991-07-15

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SUTHERLAND, Karl, M. ,  PATTERSON, William, R.

IPC: A61M01/36

CPC classification number: A61M1/3627 ,  A61M2039/0202 ,  A61M2206/11

Abstract: A blood reservoir device (10) comprising a generally flexible blood collection chamber (22) having an inlet portion (70) and a main portion (72). The inlet portion (70) is preferably sized and configured such that blood entering the inlet portion (70) will avoid turbulence and will undergo generally laminar flow through the inlet portion (70) into the main portion (72) of the chamber (22). A vent tube (66) is provided for venting coalesced or collected gas bubbles from the top edge of the chamber (22). Additionally, one or more filter elements may be positioned within the chamber (22) to further facilitate removal of air bubbles from blood passing through the chamber (22).

公开(公告)号：WO1991018675A1

公开(公告)日：1991-12-12

申请号：PCT/US1991002175

申请日：1991-04-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DENNEHEY, T., Michael ,  WEST, Joseph, C., Jr.

IPC: B04B05/02

CPC classification number: A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  B04B5/0428 ,  B04B5/0442 ,  A61M2202/0092

Abstract: A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet (51) for receiving plasma, an area (63) for receiving mononuclear cells, and an outlet (53) for receiving mononuclear cell depleted plasma. The distance and flow path (65) between the inlet (51) and outlet (53) being so constructed and arranged as to cause mononuclear cells to sediment out into the area (63) for receiving the mononuclear cells and causing at least 66 % of the platelets contained in the plasma to flow to and through the outlet.

公开(公告)号：WO1991012767A1

公开(公告)日：1991-09-05

申请号：PCT/US1991000985

申请日：1991-02-12

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BECKMAN, Ronald, B. ,  BEQUETTE, Jesse, Newton

IPC: A61B05/03

CPC classification number: G01L9/0077 ,  A61B5/02154 ,  A61B5/031

Abstract: A catheter assembly (20) for measuring a fluid pressure in a body cavity includes pulse modulator (39) responsive to an electrical power source (33) for energizing a light-emitting diode (45) which has drift characteristics which vary in response to temperature. An optical sensor (22) is adapted to receive the light from the light-emitting diode (45) and to provide a measurement signal indicative of the fluid pressure in the cavity. This measurement signal has undesirable characteristics related to the thermal drift characteristics of the diode. A detection circuit (58, 60) detects the measurement signal and provides an output signal indicative of fluid pressure in the cavity. A special filter (63) is included in this detection circuit which has optical characteristics that substantially offset the undesirable characteristics of the measurement signal, so that the output signal is substantially independent of the temperature of the diode. A power conversion circuit (36) enables the assembly to be energized by an excitation voltage which is provided in several different forms by various monitors.

Abstract translation: 用于测量体腔内的流体压力的导管组件（20）包括响应于电源（33）的脉冲调制器（39），用于激励发光二极管（45），所述发光二极管具有响应于温度变化的漂移特性 。 光学传感器（22）适于接收来自发光二极管（45）的光，并提供指示空腔中的流体压力的测量信号。 该测量信号具有与二极管的热漂移特性相关的不期望的特性。 检测电路（58,60）检测测量信号并提供指示空腔中的流体压力的输出信号。 该检测电路中包括一个特殊的滤波器（63），其具有基本上抵消测量信号的不良特性的光学特性，使得输出信号基本上与二极管的温度无关。 电力转换电路（36）使组件能够通过各种监视器以几种不同形式提供的激励电压来激励。

公开(公告)号：WO1991010946A1

公开(公告)日：1991-07-25

申请号：PCT/US1990006926

申请日：1990-11-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MATTHEWS, Joseph, B. ,  BOWMAN, George, A.

IPC: G05B19/40

CPC classification number: A61M5/14228 ,  A61M2205/8212 ,  H02P8/16

Abstract: The present invention provides a drive signal for a peristaltic pump motor (42). A first circuit is provided which generates a first series of pulses (SF) at a given frequency. A second circuit is provided which generates a second series of pulses (M4) having a frequency higher than the frequency of the first series of pulses. A third circuit is provided which generates a third series of pulses (M3A) having a frequency between the frequency of the first (SF) and second (M4) series of pulses. Finally, a circuit is provided which combines the three series of pulses into a drive signal (M3). The drive signal length is determined by the frequency of the first series of pulses (SF). The drive signal further is divided into two sections, an initial pulse stage determined by the frequency of the third series of pulses (M3A), and a modulated pulse stage being a series of pulses determined by the frequency of the second series of pulses (M6).

公开(公告)号：WO1991005575A1

公开(公告)日：1991-05-02

申请号：PCT/US1990005804

申请日：1990-10-10

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HALL, John, P. ,  BECKMAN, Ronald, B.

IPC: A61M01/00

CPC classification number: A61B5/412 ,  A61B5/031 ,  A61B2562/0261 ,  A61M27/006 ,  G01L9/0077 ,  G01L9/0079

Abstract: A monitor-driven intracranial catheter assembly including a dual lumen catheter (70, 72) for monitoring intracranial pressure via a pressure sensor (76) located in one lumen while simultaneously draining cerebrospinal fluid through the other lumen (72, 66). The pressure sensor (76) is preferebly a spectral modulation sensor that communicates with a photodetector apparatus by means of a single optical fiber (98), thus minimizing the diameter of the catheter. The photodetector is self-correcting for signal errors caused by temperature change, changes in intensity of the input light, and transmission losses within the optical apparatus. Moreover, the photodetector operates off the output voltage of the standard hospital monitor by ''scaling'' the signal from the monitor to provide a pressure measurement signal that emulates the output of a piezoresistive strain gauge sensor or Wheatstone bridge. Therefore, the entire catheter assembly is designed to be used with any of the common types of hospital monitors. The pressure monitoring catheter assembly can be used in any situation requiring very sensitive pressure measurements and can be zeroed and calibrated in situ.

Abstract translation: 一种监视器驱动的颅内导管组件，其包括用于通过位于一个腔中的压力传感器（76）监测颅内压的双腔导管（70,72），同时将脑脊液排出另一腔（72,66）。 压力传感器（76）优选地是光谱调制传感器，其通过单个光纤（98）与光电检测器装置连通，从而使导管的直径最小化。 光电检测器对由温度变化引起的信号误差，输入光的强度变化以及光学设备内的传输损耗进行自校正。 此外，光电检测器通过“缩放”来自监视器的信号来操作标准医院监视器的输出电压，以提供模拟压阻应变仪传感器或惠斯通电桥的输出的压力测量信号。 因此，整个导管组件被设计成与任何常见类型的医院监护仪一起使用。 压力监测导管组件可用于需要非常敏感的压力测量的任何情况，并且可以原位置零和校准。

公开(公告)号：WO1990013318A1

公开(公告)日：1990-11-15

申请号：PCT/US1990002167

申请日：1990-04-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ROSE, Sam ,  BUCHANAN, Glenn, C.

IPC: A61L02/08

CPC classification number: A61L2/04

Abstract: Sterile interconnection between disassociated segments of thermostable, compressible fluid conduit tubing (22A, 22B) is achieved by arranging within the bore of the free end of each segment a conductive hollow metal tube (30) so as to establish a connected fluid flow path from one segment to the other, through the metal tube (30) and then sterilizing the connection by induction heating.

Abstract translation: 通过在每个段的自由端的孔内布置导电中空金属管（30）以便建立从一个连接的流体流动路径，实现热稳定的可压缩流体管道管道（22A，22B）的分离段之间的无菌互连 通过金属管（30），然后通过感应加热对连接进行消毒。

公开(公告)号：WO1990011347A1

公开(公告)日：1990-10-04

申请号：PCT/US1990001332

申请日：1990-03-12

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BLIEM, Rudolf, F. ,  LONG, James, F.

IPC: C12M03/00

CPC classification number: B01F3/04836 ,  B01F3/04106 ,  B01F3/04262 ,  B01F3/04609 ,  B01F7/00341 ,  B01F7/162 ,  B01F2003/04134 ,  B01F2003/04326 ,  B01F2003/04361 ,  B01F2003/04652 ,  B01F2003/0468 ,  B01F2003/04879 ,  B01F2005/0088 ,  B01F2015/00597 ,  B01F2215/0073 ,  C12M23/24 ,  C12M29/16 ,  Y10S435/818

Abstract: A static oxygenator (10) for oxygenating a liquid, particularly a suspension culture of animal cells in a liquid culture medium, comprised of a bottom gassing portion comprised of generally concentric vertically oriented hollow cylinders (16, 18) of porous gas-permeable, liquid-impermeable material, and an upper degassing section comprised of vertical extensions of the concentric cylinders such that at least one liquid overflow weir (17) is provided at the juncture between the bottom and upper sections. Gas directed into the bottom of the annular space (15) between the concentric cylinders (16, 18) rises therein and, across the porous material, oxygenates liquid in contact therewith or in proximity thereto up to the point where the liquid overflows the weir (17) and the gas then continues up the annular space in the vertical extensions for degassing through the porous material above the liquid level.

公开(公告)号：WO1990011095A2

公开(公告)日：1990-10-04

申请号：PCT/US1990001182

申请日：1990-03-05

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MINSHALL, Billy, W. ,  PUROHIT, Kailash ,  NYGARD, John, E. ,  SINTIM-DAMOA, Kwame ,  GIESLER, Richard ,  WOODWORTH, Archie

IPC: A61L0

CPC classification number: A61L2/20 ,  A61L2/0023 ,  A61L2/08 ,  A61M1/0209

Abstract: A sterile product and a method for sterilizing and assembling such a product are disclosed wherein the product has two or more portions, such as a medical fluid containing portion (12) and a flow control apparatus portion (14), which are mutually incompatible with regard to the method of sterilization. The sterile product is preferably produced by exposing one portion of the product, e.g., the flow control apparatus (14), to a first form of sterilization such as an electron beam, while shielding the other portion of the product, e.g., the medical fluid containing portion (12), from the first form of sterilization. The product may be integral, with the step of sterilizing the first portion occurring while the other product portion remains attached in close association therewith. The present invention has particular application in association with a product having first and second incompatible portions (12 and 14) which are joined by a flow path. In such a product, each product portion and its respective flow path portion may be sterilized in the appropriate manner. The flow path may then be isolated from the respective product portion and the flow paths joined together. Subsequent to joinder, the isolated portion of the flow path may be sterilized, as by electron beam, while any product portion incompatible with such form of sterilization is shielded from the effects of the sterilization.

公开(公告)号：WO1990009102A1

公开(公告)日：1990-08-23

申请号：PCT/US1990000639

申请日：1990-02-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CARPENTIER, Alain ,  CARPENTIER, Sophie ,  NASHEF, Aws

IPC: A01N01/02

CPC classification number: A61L27/3687 ,  A61L2400/02 ,  A61L2430/40

Abstract: Calcification resistant bioprosthetic implants are made from tanned biological materials, such as porcine heart valves, bovine pericardium, human dura mater or the like, which has been impregnated with a calcification-mitigating effective amount of a ferric and/or stannic salt, and having been treated with one or more diamines in combination with one or more activating factors. The impregnated biological materials and processes are particularly advantageous for the preparation of bioprosthetic heart valves. These implants have been found to be highly resistant to calcification in vivo.

Abstract translation: 抗钙化生物假体植入物由鞣制的生物材料制成，例如猪心脏瓣膜，牛心包膜，人体硬脑膜等，其已浸渍有缓解钙化的有效量的三价铁和/或锡盐，并已被 用一种或多种二胺与一种或多种活化因子组合治疗。 浸渍的生物材料和方法对于制备生物假体心脏瓣膜特别有利。 已经发现这些植入物在体内对钙化具有很高的抗性。

公开(公告)号：WO1990008492A1

公开(公告)日：1990-08-09

申请号：PCT/US1990000175

申请日：1990-01-17

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  JOST, George ,  TSENG, Charles, Chun-Shu

IPC: A47G29/00

CPC classification number: A61M5/1415 ,  F16M11/046 ,  F16M11/42 ,  F16M2200/027 ,  F16M2200/08

Abstract: A stable and highly maneuvrable home care intravenous stand having a long/wide platform base with front base casters (40) and back base wheels (46). The stand has a removable main and a telescoping sub-pole (10-12) to allow for easy storage.