公开(公告)号：AU2011227374A1

公开(公告)日：2012-10-11

申请号：AU2011227374

申请日：2011-03-16

Applicant: BUCKMAN LABOR INC

Inventor： WIATR CHRISTOPHER L ,  CORCORAN MICHAEL L ,  MCNEEL THOMAS E ,  CLARK RICHARD A ,  PORTO RITA DE CASSIA BORTOTO ,  OPPONG DAVID

IPC: C12P7/06 ,  A23K10/38 ,  A23L7/104 ,  C12N1/16 ,  C12R1/01

Abstract: Methods for controlling the growth of bacteria in ethanol fermentation systems with antibiotic alternatives, which can be nonoxidizing biocides, stabilized oxidizers, or any combinations thereof, are described. As an option, a process or composition of the present invention can include one or more polycyclic antibacterial peptides. The methods can provide improvements, such as increased ethanol yields with minimal carryover of biocide into co-products of the processes.

公开(公告)号：CA2793614A1

公开(公告)日：2011-09-22

申请号：CA2793614

申请日：2011-03-16

Applicant: BUCKMAN LABOR INC

Inventor： WIATR CHRISTOPHER L ,  CORCORAN MICHAEL L ,  MCNEEL THOMAS E ,  CLARK RICHARD A ,  PORTO RITA DE CASSIA BORTOTO ,  OPPONG DAVID

IPC: C12P7/06 ,  A23K10/38 ,  A23L7/104 ,  C12N1/16

Abstract: Methods for controlling the growth of bacteria in ethanol fermentation systems with antibiotic alternatives, which can be nonoxidizing biocides, stabilized oxidizers, or any combinations thereof, are described. As an option, a process or composition of the present invention can include one or more polycyclic antibacterial peptides. The methods can provide improvements, such as increased ethanol yields with minimal carryover of biocide into co-products of the processes.

公开(公告)号：ES2260842T3

公开(公告)日：2006-11-01

申请号：ES98937151

申请日：1998-07-27

Applicant: BUCKMAN LABOR INC

Inventor： MCNEEL THOMAS E ,  WHITTEMORE MARILYN S ,  BRYANT STEPHEN D ,  VUNK GRACIELA H

IPC: A01N57/18 ,  C02F1/50

Abstract: La utilización de un ácido amino metil fosfónico o sus sales para inhibir la adhesión bacteriana en superficies sumergibles, donde dicho ácido amino metil fosfónico es un compuesto con la fórmula R1R2NCH2P(O)(OH)2, donde R1 es hidrógeno, un grupo alquil C6-C20, o un grupo CH2P(O)(OH)2 y R2 es independientemente un grupo alquil C6C20 o un grupo CH2P(O)(OH)2 pero R1 y R2 no son ambos un grupo CH2P(O)(OH)2; o R1 y R2, junto con la N, forman un anillo heterocíclico de 5-8 miembros con la fórmula: (Ver fórmula) en la cual X es O, HN o CH2; y donde las sales de un ácido amino metil fosfónico son unas sales de ácido o unas sales cuaternizadas de ácido amino metil fosfónico.

公开(公告)号：AT324353T

公开(公告)日：2006-05-15

申请号：AT98937151

申请日：1998-07-27

Applicant: BUCKMAN LABOR INC

Inventor： MCNEEL THOMAS E ,  WHITTEMORE MARILYN S ,  BRYANT STEPHEN D ,  VUNK GRACIELA H

IPC: A01N57/18 ,  C02F1/50

Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The amino methyl phosphonic acid used in the methods of the invention has the formula R1R2NCH2P(O)(OH)2. In this formula, R1 and R2 are independently a C6-C20 alkyl group or a CH2P(O)(OH)2 group. However, R1 and R2 are not both a CH2P(O)(OH)2 group. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: In the heterocyclic ring, X is O, NH, or CH2. The salt of an amino methyl phosphonic acid can be an acid salt or a quaternized amino methyl phosphonic acid salt. The invention also relates to a composition containing amino methyl phosphonic acids or salts thereof and useable in the above methods. The compositions comprise at least one amino methyl phosphonic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.

公开(公告)号：AT304700T

公开(公告)日：2005-09-15

申请号：AT99964068

申请日：1999-12-02

Applicant: BUCKMAN LABOR INC

Inventor： DICKINSON WAYNE H ,  MCNEEL THOMAS E ,  VAN HAUTE EDDIE ,  CLARK RICHARD A

IPC: G01N33/18 ,  C02F1/00 ,  C12M1/34 ,  C12N1/00 ,  C12Q1/02 ,  G01N17/00

公开(公告)号：NZ502572A

公开(公告)日：2002-08-28

申请号：NZ50257298

申请日：1998-07-27

Applicant: BUCKMAN LABOR INC

Inventor： MCNEEL THOMAS E ,  WHITTEMORE MARILYN S ,  BRYANT STEPHEN D ,  VUNK GRACIELA H

IPC: A01N41/02 ,  A61K8/46 ,  A61Q11/00 ,  A61K8/40 ,  C02F1/50 ,  A61K7/22

Abstract: A method for inhibiting bacteria from adhering to a submergible surface is disclosed. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used herein has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. A composition containing sulfamic acids or salts thereof useable in the above methods is also disclosed. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.

公开(公告)号：CA2352665A1

公开(公告)日：2000-06-02

申请号：CA2352665

申请日：1999-11-24

Applicant: BUCKMAN LABOR INC

Inventor： HEINDEL NED D ,  LASKIN JEFFREY D ,  HECK DIANE E ,  RAPP ROBERT D ,  MCNEEL THOMAS E ,  JABIN IVAN ,  WHITTEMORE MARILYN S

IPC: A61P17/06 ,  A61P35/00 ,  C07D311/44 ,  C07D311/56 ,  C07D493/04 ,  C07F3/14 ,  C07D307/00 ,  C07D311/00 ,  A61K31/34

Abstract: 5'- substituted, 4', 5'- dihydropsoralen compounds (5) bearing tertiary amin es (and salts thereof), quaternary ammonium moieties or organomercurial moietie s are described. Also described are 2- substituted mercurimethyl -2-3- dihydro - benzofurans of formula (7). Also reported are versatile direct syntheses through a hitherto unknown compounds such as 3-R-4, 8-dimethyl -4',5'-dihydr o - 5'-bromomethylpsoralen or a 3-R-4, 8-dimethyl-4, 5'-dihydro- 5'- iodomethylpsoralen to prepare a structurally diverse array of partially reduced psoralens and benzofurans. The presence of a permanent ammonium char ge in these psoralens precludes membrane passage and the mono-unsaturation precludes the cross linking of nuclear DNA, thereby minimizing the mutagenic/carcinogenic side effects long associated with psoralen-derived therapies. The presence of a mercury functionality provides a reactive cell- binding group on these psoralens with unique cytotoxicity without light activation and an enhancement of cytotoxicity activity upon light activation . The invention also relates to these partially reduced and quaternized psoralens, amino-substituted psoralens, and mercurio psoralens display impressive pharmacology against PAM 212 keratinocytes, a model cell line employed as a test system to indicate epidermal cytotoxicity and cancer. The compounds of the invention also have antimicrobicidal activity useful in pharmacologic agents for mammals (e.g. the treatment of tuberculosis) as wel l as in controlling the growth of microorganisms on substrates and in aqueous systems.

公开(公告)号：CA2298607A1

公开(公告)日：1999-02-11

申请号：CA2298607

申请日：1998-07-27

Applicant: BUCKMAN LABOR INC

Inventor： VUNK GRACIELA H ,  BRYANT STEPHEN D ,  MCNEEL THOMAS E ,  WHITTEMORE MARILYN S

IPC: A61K8/40 ,  A01N41/02 ,  A61K8/46 ,  A61Q11/00 ,  C02F1/50 ,  A61K7/22

Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having formula (I). In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.

公开(公告)号：ES2120500T3

公开(公告)日：1998-11-01

申请号：ES93910959

申请日：1993-05-06

Applicant: BUCKMAN LABOR INC

Inventor： RAYUDU S RAO ,  FENYES JOSEPH G ,  MCNEEL THOMAS E

IPC: A01N35/02 ,  A01N35/04 ,  C10M129/24 ,  C10N30/16 ,  C10N40/20

Abstract: Halogenated 4'-methoxyacetophenones of formula I: logen; and n is 1 or 2 as microbicides for inhibiting the growth of microorganisms in aqueous systems and on surfaces, as well as for inhibiting slime formation in aqueous systems and biocidal compositions containing effective amounts of the halogenated 4'-methoxyacetophenones.

公开(公告)号：BR9306502A

公开(公告)日：1998-09-15

申请号：BR9306502

申请日：1993-05-06

Applicant: BUCKMAN LABOR INC

Inventor： RAYUDU S RAO ,  MCNEEL THOMAS E ,  FENYES JOSEPH G

IPC: A01N35/02 ,  A01N35/04 ,  C10M129/24 ,  C10N30/16 ,  C10N40/20

Abstract: Halogenated 4'-methoxyacetophenones of formula I: logen; and n is 1 or 2 as microbicides for inhibiting the growth of microorganisms in aqueous systems and on surfaces, as well as for inhibiting slime formation in aqueous systems and biocidal compositions containing effective amounts of the halogenated 4'-methoxyacetophenones.