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    PRIMARY ALCOHOL PRODUCING ORGANISMS
    72.
    发明专利
    PRIMARY ALCOHOL PRODUCING ORGANISMS 未知

    公开(公告)号：ZA201007065B

    公开(公告)日：2011-07-27

    申请号：ZA201007065

    申请日：2010-10-04

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  PHARKYA PRITI ,  SUN JUN

    Abstract: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.

    MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS
    74.
    发明专利
    MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS 未知

    公开(公告)号：CA2719679A1

    公开(公告)日：2009-12-17

    申请号：CA2719679

    申请日：2009-03-27

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  PHARKYA PRITI ,  OSTERHOUT ROBIN E

    IPC: C12N1/21 ,  C12N15/52 ,  C12P7/44 ,  C12P13/00 ,  C12P13/02

    Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6- aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID
    75.
    发明专利
    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 未知

    公开(公告)号：CA2722680A1

    公开(公告)日：2009-11-05

    申请号：CA2722680

    申请日：2009-04-30

    Applicant: GENOMATICA INC

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N1/00 ,  C12N9/00 ,  C12N15/00 ,  C12N15/52 ,  C12P7/40

    Abstract: The invention provides a non-naturally occurring microbial organism having a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.

    PRIMARY ALCOHOL PRODUCING ORGANISMS
    76.
    发明专利
    PRIMARY ALCOHOL PRODUCING ORGANISMS 未知

    公开(公告)号：CA3081506A1

    公开(公告)日：2009-09-11

    申请号：CA3081506

    申请日：2009-03-05

    Applicant: GENOMATICA INC

    Inventor： SUN JUN ,  PHARKYA PRITI ,  BURGARD ANTHONY P

    Abstract: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.

    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO
    77.
    发明专利
    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 未知

    公开(公告)号：AU2022205243A1

    公开(公告)日：2022-08-18

    申请号：AU2022205243

    申请日：2022-07-14

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  SUN JUN ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/12 ,  C12P7/04

    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4 hydroxybutyryl-CoA, 4- hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4 hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    79.
    发明专利
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 未知

    公开(公告)号：MY176050A

    公开(公告)日：2020-07-22

    申请号：MYPI2011005176

    申请日：2010-04-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3- hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Organismos productores de alcoholes primarios
    80.
    发明专利
    Organismos productores de alcoholes primarios 未知

    公开(公告)号：ES2703775T3

    公开(公告)日：2019-03-12

    申请号：ES09717987

    申请日：2009-03-05

    Applicant: GENOMATICA INC

    Inventor： SUN JUN ,  PHARKYA PRITI ,  BURGARD ANTHONY P

    IPC: C12P7/02 ,  C12N1/00 ,  C12N9/00

    Abstract: Organismo microbiano, que comprende una ruta de síntesis de ácidos grasos (FAS) independiente de malonil-CoA y una ruta de reducción de acilos que comprende ácidos nucleicos heterólogos que codifican una ruta de FAS independiente de malonil-CoA y ácidos nucleicos heterólogos que codifican una ruta de reducción de acilos expresados en cantidades suficientes para producir un alcohol primario, en el que dicho alcohol primario es hexanol, heptanol, octanol, nonanol, decanol, dodecanol, tetradecanol o hexadecanol, en el que dicha ruta de FAS independiente de malonil-CoA comprende cetoacil-CoA aciltransferasa o cetoacil-CoA tiolasa, 3-hidroxiacil-CoA deshidrogenasa, enoil-CoA hidratasa y enoil-CoA reductasa, y dicha ruta de reducción de acilos comprende una acil-CoA reductasa y una alcohol deshidrogenasa, en el que dicha cetoacil-CoA aciltransferasa o cetoacil-CoA tiolasa convierte acil-CoA en β-cetoacil-CoA, en el que dicha 3-hidroxiacil-CoA deshidrogenasa convierte β-cetoacil-CoA en β-hidroxiacil-CoA, en el que dicha enoil-CoA hidratasa convierte β-hidroxiacil-CoA en trans-2-enoil-CoA, en el que dicha enoil-CoA reductasa convierte trans-2-enoil-CoA en acil-CoA, en el que dicha acil-CoA reductasa convierte acil-CoA en un aldehído, en el que dicha alcohol deshidrogenasa convierte un aldehído en dicho alcohol primario.

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