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公开(公告)号:FI892686A
公开(公告)日:1989-12-05
申请号:FI892686
申请日:1989-06-01
Applicant: HOECHST AG
Inventor: CRAUSE PETER , HABERMANN PAUL , KRAMER MARTIN , OBERMEIER RAINER , SAUBER KLAUS , TRIPIER DOMINIQUE
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/00 , A61K47/48 , A61P7/02 , C07K1/113 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , C07K17/10 , C12P21/02 , C12R1/645 , C07K
Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.
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公开(公告)号:DK270989A
公开(公告)日:1989-12-04
申请号:DK270989
申请日:1989-06-02
Applicant: HOECHST AG
Inventor: SCHULZ ARNO , BARTSCH KLAUS , TRIPIER DOMINIQUE , SAUBER KLAUS
Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.
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公开(公告)号:PT88975A
公开(公告)日:1989-11-30
申请号:PT8897588
申请日:1988-11-10
Applicant: HOECHST AG
Inventor: HABERMANN PAUL , TRIPIER DOMINIQUE , CRAUSSE PETER , BADZIONG WERNER
IPC: G01N30/88 , A61K35/62 , B01D15/08 , C07K1/14 , C07K1/20 , C07K14/00 , C07K14/435 , C07K14/815 , G01N30/26 , C07K7/20
Abstract: Hirudin is isolated and purified from complex and salt-containing solutions by hydrophobic chromatography employing porous adsorber resins as stationary phase and water-miscible organic solvents as mobile phase.
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公开(公告)号:DK560989D0
公开(公告)日:1989-11-09
申请号:DK560989
申请日:1989-11-09
Applicant: HOECHST AG
Inventor: HUCHO FERDINAND , PRIBILLA IRIS , SCHIEBLER WERNER , TRIPIER DOMINIQUE , KOGLER HERBERT
IPC: A61K31/195 , A61K31/19 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07C229/16
Abstract: The present invention relates to the use of EDTA or its analogues as inhibitors of calcium/calmodulin-dependent protein kinase II or of protein kinase C.
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公开(公告)号:NO890758L
公开(公告)日:1989-08-24
申请号:NO890758
申请日:1989-02-22
Applicant: HOECHST AG
Inventor: CRAUSE PETER , HABERMANN PAUL , TRIPIER DOMINIQUE
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公开(公告)号:HU198085B
公开(公告)日:1989-07-28
申请号:HU134185
申请日:1985-04-11
Applicant: HOECHST AG
Inventor: TRIPIER DOMINIQUE
IPC: C07K1/113 , A61K35/56 , A61K35/62 , A61K38/00 , A61K38/46 , A61K38/55 , A61P7/02 , C07C20060101 , C07G20060101 , C07K1/20 , C07K14/00 , C07K14/815 , C07K3/02 , C07K7/10 , A61K37/64
Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.
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公开(公告)号:DK13189A
公开(公告)日:1989-07-14
申请号:DK13189
申请日:1989-01-12
Applicant: HOECHST AG
Inventor: CRAUSE PETER , HABERMANN PAUL , TRIPIER DOMINIQUE
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公开(公告)号:FI892689A0
公开(公告)日:1989-06-01
申请号:FI892689
申请日:1989-06-01
Applicant: HOECHST AG
Inventor: SCHULZ ARNO , BARTSCH KLAUS , TRIPIER DOMINIQUE , SAUBER KLAUS
Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.
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公开(公告)号:CA1232218A
公开(公告)日:1988-02-02
申请号:CA434452
申请日:1983-08-12
Applicant: HOECHST AG
Inventor: SEIPKE GERHARD , TRIPIER DOMINIQUE , JOHNSCHER GERD
IPC: A61K35/26 , A61K38/00 , A61K38/22 , A61P37/00 , C07K1/113 , C07K1/20 , C07K7/04 , C07K14/435 , C07K14/47 , C07K14/575 , A61K37/18 , C12P21/06 , C07K3/28
Abstract: of the disclosure: The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm, and an isoelectric point of 3.95 + 0.15 and a specific aminoacid composition, the N-terminal, if appropriate, carrying an acyl group or an acylglycyl group, processes for its isolation and purification, its use, agents containing this polypeptide, and its cleavage products, their use and agents containing them.
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公开(公告)号:ES2000216A6
公开(公告)日:1988-01-16
申请号:ES8600317
申请日:1986-07-15
Applicant: HOECHST AG
Inventor: KRAMER MARTIN , TRIPIER DOMINIQUE
IPC: C07K1/06 , A61K35/62 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/00 , C07K1/12 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C07K7/10
Abstract: EL INVENTO CONCIERNE A UN PROCEDIMIENTO PARA OBTENER UN POLIPEPTIDO DE FORMULA EN DONDE R REPRESENTA HIDROGENO FENOLICO O UN GRUPO ESTER FENOLICO Y M, N, X, Z, A, B, C, D, E, F, G, H Y J TIENEN LOS SIGNIFICADOS INDICADOS Y EN DONDE LOS 6 RADICALES CYS ESTAN UNIDOS POR PARES A TRAVES DE PUENTES DISULFURO. EL POLIPEPTIDO OBTENIDO PUEDE UTILIZARSE COMO ANTICOAGULANTE.
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