公开(公告)号：NO317666B1

公开(公告)日：2004-11-29

申请号：NO973438

申请日：1997-07-25

Applicant: HOECHST AG

Inventor： SEIPKE GERHARD ,  HABERMANN PAUL ,  GEISEN KARL ,  ERTL JOHANN

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P5/50 ,  C07K14/62

Abstract: Insulin of formula (I): R1 is H or Phe; R3, Y are genetically encodable amino acids; Z = His or a peptide chain of 2-35 genetically encodable amino acids including 1-5 His residues; A2-A20 (not shown) correspond to the amino acid sequence of the A chain of human insulin, an animal insulin or an insulin derivative; B2-B29 (not shown) correspond to the amino acid sequence of the B chain of human insulin, an animal insulin or an insulin derivative. Also claimed are: (1) a complex comprising an insulin hexamer and 5-9 zinc atoms per insulin hexamer, where the hexamer consists of six insulin molecules of formula (I); (2) proinsulin of formula (II): R2-R1'-B2-B29-Y-Z1-Gly-A2-A20-R3 (II) R1' = Phe or a covalent bond; R2 = a genetically encodable amino acid or a peptide chain of 2-45 amino acids, and Z1 is a peptide chain of 2-40 genetically encodable amino acids including 1-5 His residues.

公开(公告)号：BR9704117A

公开(公告)日：1998-12-29

申请号：BR9704117

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： GEISEN KARL ,  HABERMANN PAUL ,  ERTL JOHANN ,  SEIPKE GERHARD

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P5/50 ,  C07K14/62

Abstract: Insulin of formula (I): R1 is H or Phe; R3, Y are genetically encodable amino acids; Z = His or a peptide chain of 2-35 genetically encodable amino acids including 1-5 His residues; A2-A20 (not shown) correspond to the amino acid sequence of the A chain of human insulin, an animal insulin or an insulin derivative; B2-B29 (not shown) correspond to the amino acid sequence of the B chain of human insulin, an animal insulin or an insulin derivative. Also claimed are: (1) a complex comprising an insulin hexamer and 5-9 zinc atoms per insulin hexamer, where the hexamer consists of six insulin molecules of formula (I); (2) proinsulin of formula (II): R2-R1'-B2-B29-Y-Z1-Gly-A2-A20-R3 (II) R1' = Phe or a covalent bond; R2 = a genetically encodable amino acid or a peptide chain of 2-45 amino acids, and Z1 is a peptide chain of 2-40 genetically encodable amino acids including 1-5 His residues.

公开(公告)号：FI102076B1

公开(公告)日：1998-10-15

申请号：FI893046

申请日：1989-06-21

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  HABERMANN PAUL ,  SEIPKE GERHARD ,  UHLMANN EUGEN

IPC: C12N1/19 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07H21/04 ,  C07K7/00 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/575 ,  C07K14/62 ,  C07K19/00 ,  C12N1/21 ,  C12N15/00 ,  C12N15/17 ,  C12P21/02 ,  C12R1/19 ,  C07K15/17 ,  C07K1/20 ,  C07K1/16 ,  C07K38/28 ,  C07K21/00

Abstract: A mini-proinsulin in which the A and B chains are linked by the amino acid Arg in place of the C chain has insulin activity and is suitable for producing medicaments for the treatment of diabetes mellitus. It can also be converted straightforwardly with trypsin into an insulin derivative whose B chain is extended by Arg. The latter can be converted with carboxypeptidase B into insulin. However, it is also possible and advantageous to convert the mini-proinsulin directly into insulin in a one-pot process.

公开(公告)号：MX9705667A

公开(公告)日：1998-07-31

申请号：MX9705667

申请日：1997-07-25

Applicant: HOECHST AG

Inventor： ERTL JOHANN ,  HABERMANN PAUL ,  GEISEN KARL ,  SEIPKE GERHARD

IPC: C07K14/575 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P5/50 ,  C07K14/62 ,  C12N15/17

Abstract: Derivados de insulina con union de zinc incrementada en donde Z representa un resto histidina o un péptido con 2 a 35 restos aminoácidos genéticamente codificables, que contiene 1 a 5 restos histidina, se adecua para la produccion de preparados farmacéuticos para el tratamiento de diabetes. Las insulinas de la formula I forman con zinc complejos que contienen un hexámetro de insulina y aproximadamente 5 a 9 moles de zinc por hexámero.

公开(公告)号：HUT72033A

公开(公告)日：1996-03-28

申请号：HU9500698

申请日：1995-03-08

Applicant: HOECHST AG

Inventor： SEIPKE GERHARD ,  WALCH AXEL ,  AHLERS MICHAEL ,  RUSSEL-JONES GREGORY

IPC: A61K47/34 ,  A61K9/51 ,  A61K47/48 ,  A61P3/00 ,  C08G69/40 ,  C08G69/28 ,  B01J13/02

Abstract: Nanoparticles contg. an active ingredient (A) and a poly (ketal tartaric acid amide) (B) with at least 95 mole% of repeating units of formula (I) are new: X = NH; R2 = alkyl or cycloalkyl, opt. with 1 or more inert substits.

公开(公告)号：NO173194C

公开(公告)日：1993-11-10

申请号：NO885154

申请日：1988-11-18

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  SEIPKE GERHARD

IPC: C07K14/62 ,  C07K19/00 ,  C12N9/52 ,  C12N15/00 ,  C12N15/62 ,  C12P21/02 ,  C12P21/06 ,  C07K7/40

Abstract: Polypeptides or proteins are prepared by enzymatic cleavage of the oligo- or polyglycine sequence of a fusion protein by means of endoprotease.

公开(公告)号：FI85494B

公开(公告)日：1992-01-15

申请号：FI854383

申请日：1985-11-07

Applicant: HOECHST AG

Inventor： BICKER RICHARD ,  SEIPKE GERHARD

IPC: C07K1/14 ,  C07K1/00 ,  C07K1/107 ,  C07K1/12 ,  C07K3/00

Abstract: The invention relates to a process for the cleavage of peptides and proteins at the methionyl bond using cyanogen chloride.

公开(公告)号：FI79860B

公开(公告)日：1989-11-30

申请号：FI820117

申请日：1982-01-14

Applicant: HOECHST AG

Inventor： OBERMEIER RAINER ,  LUDWIG JUERGEN ,  SEIPKE GERHARD

IPC: C12P21/02 ,  A61K38/28 ,  C07K1/12 ,  C07K14/62 ,  C07K7/40

Abstract: What is disclosed is a method for making human insulin or modified human insulin from pig insulin or modified pig insulin by reacting the pig insulin starting material at a pH below its isoelectric point with an excess of a threonine ester in the presence of trypsin or a trypsin-like enzyme.

公开(公告)号：ZA8808650B

公开(公告)日：1989-07-26

申请号：ZA8808650

申请日：1988-11-18

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  MICHAEL DOERSCHUG ,  SEIPKE GERHARD ,  GERHARD SEIPKE

IPC: C07K14/62 ,  C07K19/00 ,  C12N15/62 ,  C12P21/06 ,  C07K ,  A61K ,  C12P

CPC classification number: C12N15/62 ,  C07K14/62 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/61 ,  C07K2319/75 ,  C12P21/06

公开(公告)号：DK309989D0

公开(公告)日：1989-06-22

申请号：DK309989

申请日：1989-06-22

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  HABERMANN PAUL ,  SEIPKE GERHARD ,  UHLMANN EUGEN

IPC: C12N1/19 ,  A61K38/00 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  C07H21/04 ,  C07K7/00 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/575 ,  C07K14/62 ,  C07K19/00 ,  C12N1/21 ,  C12N15/00 ,  C12N15/17 ,  C12P21/02 ,  C12R1/19 ,  C07K7/40

Abstract: A mini-proinsulin in which the A and B chains are linked by the amino acid Arg in place of the C chain has insulin activity and is suitable for producing medicaments for the treatment of diabetes mellitus. It can also be converted straightforwardly with trypsin into an insulin derivative whose B chain is extended by Arg. The latter can be converted with carboxypeptidase B into insulin. However, it is also possible and advantageous to convert the mini-proinsulin directly into insulin in a one-pot process.